Reticulin staining pattern in the differential diagnosis of benign parathyroid lesions

Çabuk, Fatmagül Kuşku; Sar, Mehmet; Canoğlu, Didem; Dural, C. A.; Güneş, Mehmet Emin

doi:10.1007/s40618-020-01239-z

Cited by 2 publications

(7 citation statements)

References 15 publications

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“…In the diagnosis of pituitary adenoma, the appearance of the traversable line, mentioned in our report, is a qualitative indication of RFS destruction [8]. We observed a sparse RFS or even loss of the RFS in PTAs in this study, consistent with the ndings of Kuşku et al [4]. Although the RFS in this area is incomplete, it does not represent true destruction but may rather re ect slender reticular bres or the spatial characteristics of the RFS.…”

Section: Discussionsupporting

confidence: 89%

“…The RFS was discontinuous in a few areas and exhibited an irregular sinusoid structure. Kuşku et al [4] performed reticular bre staining on 97 parathyroid lesions in 85 patients. Their results showed short, thick bres and anastomosing and nodular RFS in PTA.…”

Section: Discussionmentioning

confidence: 99%

“…They reported that the main RFS in PTA can be de ned as short, thick bre, anastomotic bre, and nodular bre types [4]. The short, thick reticular bres are associated with PTA and hyperplasia, whereas the nodular type supports PTA [4]. However, APT and PTC were not investigated in their study.Therefore, in the present study, we investigated the characteristics of RFS in PTA, APT, and PTC and assessed the value of RFS as a diagnostic indicator for parathyroid neoplasms.…”

mentioning

confidence: 92%

“…Kuçabuk et al rst reported RFS of PTA. They reported that the main RFS in PTA can be de ned as short, thick bre, anastomotic bre, and nodular bre types [4]. The short, thick reticular bres are associated with PTA and hyperplasia, whereas the nodular type supports PTA [4].…”

mentioning

confidence: 99%

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Reticular fibre structure in the differential diagnosis of parathyroid neoplasms

Jiang

et al. 2023

Preprint

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Background To investigate the characteristics of reticular fibre structure (RFS) in parathyroid adenoma (PTA), atypical parathyroid tumour (APT), and parathyroid carcinoma (PTC), and to assess its value as a diagnostic indicator. Methods Clinical data and pathological specimens of patients with PTA, APT or PTC were collected. Reticular fibre staining was performed to observe the characteristics of RFS. This study evaluated the incidence of RFS destruction in parathyroid tumours, compared RFS destruction between primary PTC and recurrent and metastatic PTC, and explored the association between RFS destruction and clinicopathological features of APT and primary PTC. Results Reticular fibre staining was performed in 50 patients with PTA, 25 patients with APT, and 36 patients with PTC. In PTA cases, a delicate RFS was observed. In both the APT and PTC groups, incomplete RFS areas were observed. The incidence of RFS destruction was different among the PTA, APT, and PTC groups (P < 0.001, χ2-test), at 0% (0/50), 44% (11/25), and 86% (31/36), respectively. When differentiating PTC from APT, the sensitivity and specificity of RFS destruction were 81% and 56%, respectively. The incidence of RFS destruction was 73% (8/11) in the primary PTC group and 92% (23/25) in the recurrent and metastatic PTC groups. In both the APT group and primary PTC group, no correlation was found between RFS destruction and clinicopathological features. Conclusion RFS destruction may indicate that parathyroid tumours have unfavourable biological behaviours.Reticular fibre staining may be a valuable tool for improving the diagnostic accuracy in parathyroid tumours.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 92%

mentioning

confidence: 99%

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Reticular fibre structure in the differential diagnosis of parathyroid neoplasms

Jiang

et al. 2023

Preprint

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“…They reported that the main RFS in PTA can be defined as short, thick fibre, anastomotic fibre, and nodular fibre types [ 4 ]. The short, thick reticular fibres are associated with PTA and hyperplasia, whereas the nodular type supports PTA [ 4 ]. However, APT and PTC were not investigated in their study.…”

Section: Introductionmentioning

confidence: 99%

Reticular fibre structure in the differential diagnosis of parathyroid neoplasms

Jiang

et al. 2023

Diagn Pathol

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Reticulin staining pattern in the differential diagnosis of benign parathyroid lesions

Cited by 2 publications

References 15 publications

Reticular fibre structure in the differential diagnosis of parathyroid neoplasms

Reticular fibre structure in the differential diagnosis of parathyroid neoplasms

Reticular fibre structure in the differential diagnosis of parathyroid neoplasms

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