Reticular fibre structure in the differential diagnosis of parathyroid neoplasms

Hu, Xiumei; He, Shaoming; Jiang, Xingran; Wei, Ping; Zhou, Xiang; Shi, Zhongyue; Li, Xue; Lu, Jun; Zhao, Hongying; Wei, Bojun; Jin, Mulan

doi:10.1186/s13000-023-01368-y

Cited by 4 publications

(3 citation statements)

References 18 publications

(25 reference statements)

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“…The signi cance of reticular ber staining in diagnosing parathyroid tumors, adrenocortical adenomas, and pituitary adenomas is well-established [21][22]. Reticular bers, challenging to discern under H&E staining, become readily observable post-immersion in a silver ammonia solution and subsequent reduction with formaldehyde, yielding a black color.…”

Section: Discussionmentioning

confidence: 99%

Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors

Hu,

Dai,

Guo

et al. 2024

Preprint

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Background: Our study aimed to determine the incidence, patient characteristics, and clinical outcomes of patients with newly diagnosed myeloma (NDMM) with bone marrow fibrosis (BMF). Methods: The clinical data, histological features, and clinical outcomes of patients with NDMM were collected. Reticular fiber staining was performed on the enrolled cases, the degree of reticular fiber hyperplasia was graded, and the incidence of BMF was calculated. The differences in clinical data, histological features, and clinical outcomes between the BMF+ group and the BMF– group were compared. Results: The study involved a consecutive series of 146 patients with NDMM. The incidence of MF-0, MF-1, MF-2, and MF-3 was 7.53% (11/146), 34.93% (51/146), 51.37% (75/146), and 6.16% (9/146), respectively. Patients with MF-2 and MF-3 were classified as the BMF+ group, and those with MF-0 and MF-1 were classified as the BMF- group. The incidence of BMF, namely MF-2 and MF-3, was observed to be 57.53% (84/146). A significant correlation was identified between the pattern of infiltration and BMF (P<0.001); furthermore, BMF was associated with a diffuse infiltration pattern. The overall survival (OS) of the BMF+ group (39.177 months; 95% confidence interval [CI]: 34.031–44.323) was lower than that of the BMF- group (45.430 months; 95% CI: 39.524–51.337), but there was no significant difference between the two groups (P = 0.221). Univariate and multivariate analysis showed that the BMF+ status was not associated with OS in patients with NDMM (P = 0.381,0.748). Conclusions: Our findings suggest that BMF is linked to a diffuse infiltration pattern, and its occurrence is not related to the prognosis of patients with NDMM. Thus, this study provides a basis for further exploring the value of BMF in the diagnosis and treatment of NDMM.

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Section: Discussionmentioning

confidence: 99%

Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors

Hu,

Dai,

Guo

et al. 2024

Preprint

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“…There are only a small number of sparse reticular fibers around the tumor cancer nest with good differentiation and low malignancy, or no reticular fibers. In contrast, poorly differentiated and aggressive tumor nests can be surrounded by abundant, dense reticular fibers [ 39 ]. It has also been suggested that the perivascular fibrostroma favors tumor invasion and dissemination [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation of functional magnetic resonance imaging features of primary central nervous system lymphoma with vasculogenic mimicry and reticular fibers

Qi,

Zheng,

et al. 2024

Heliyon

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“…The significance of reticular fiber staining in diagnosing parathyroid tumors, adrenocortical adenomas, and pituitary adenomas is well-established [ 31 , 32 ]. Reticular fibers, challenging to discern under H&E staining, become readily observable post-immersion in a silver ammonia solution and subsequent reduction with formaldehyde, yielding a black color.…”

Section: Discussionmentioning

confidence: 99%

Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors

Hu,

Dai,

Guo

et al. 2024

Diagn Pathol

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Background Bone marrow fibrosis (BMF) severely impacts both the quality of life and the efficacy of diagnostic procedures. However, the correlation between BMF and clinicopathological features, cytogenetic changes, and prognosis of newly diagnosed multiple myeloma (NDMM) remains unclear. This study determined the incidence, patient characteristics, and clinical outcomes of patients with NDMM with BMF. Methods The clinical data, histological features, and clinical outcomes of patients with NDMM were collected. Reticular fiber staining was performed on the enrolled cases, and the degree of reticular fiber overgrowth was graded. Patients with MF-2 and MF-3 were classified as the BMF+ group, and those with MF-0 and MF-1 were classified as the BMF- group, and BMF incidence was calculated. The differences in clinical data, histological features, and clinical outcomes between the BMF+ group and the BMF– group were compared. Results A consecutive series of 146 patients with NDMM were included. The incidence of MF-0, MF-1, MF-2, and MF-3 was 7.53% (11/146), 34.93% (51/146), 51.37% (75/146), and 6.16% (9/146), respectively. The incidence of BMF—MF-2 and MF-3—was 57.53% (84/146). A significant correlation was identified between the pattern of infiltration and BMF (P < 0.001). In the BMF- group, the distribution of cases with interstitial, nodular, and diffuse infiltration of plasma cells was 16 (25.8%), 21 (33.9%), and 25 (40.3%), respectively. Conversely, in the BMF+ group, these values for interstitial, nodular, and diffuse tumor cells were 9 (10.7%), 15 (17.9%), and 60 (71.4%). Furthermore, BMF was associated with a diffuse infiltration pattern. The overall survival (OS) of the BMF+ group (39.1 months; 95% confidence interval [CI]: 34.0–44.3) was lower than that of the BMF- group (45.4 months; 95% CI: 39.5–51.3), but there was no significant difference between the two groups (P = 0.221). Univariate and multivariate analyses showed that the BMF+ status was not associated with OS in patients with NDMM (P = 0.381 and P = 0.748, respectively). Conclusions Our findings suggest that BMF is linked to a diffuse infiltration pattern, and its occurrence is not related to the prognosis of patients with NDMM, providing a basis for further exploring the BMF value in NDMM diagnosis and treatment.

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Reticular fibre structure in the differential diagnosis of parathyroid neoplasms

Cited by 4 publications

References 18 publications

Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors

Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors

Correlation of functional magnetic resonance imaging features of primary central nervous system lymphoma with vasculogenic mimicry and reticular fibers

Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors

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