Reticular erythematous mucinosis syndrome*

Smith, N.P.; Sanderson, K.V.; Crow, K. D.

doi:10.1111/j.1365-2230.1976.tb01404.x

Cited by 21 publications

(14 citation statements)

References 3 publications

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“…The mucin gives variable staining reactions. Colloidal iron staining has proven to be better than Alcian blue, which on occasions has yielded false negatives 33,34 …”

Section: Diagnosis/histopathologymentioning

confidence: 99%

Reticular erythematous mucinosis – a review

et al. 2012

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Reticular erythematous mucinosis (REM) is a rare cutaneous condition often referred to as plaque-like mucinosis and midline mucinosis. Although the exact etiology remains undefined, efforts to elucidate pathogenesis, disease associations, and prospective treatment modalities have been encouraging. Induction of the disease has been associated with viral processes, solar irradiation, specific cell lines, and cytokines such as Interleukin (IL)-1β. Clinically, patients typically develop erythematous macules and papules that coalesce into reticulated patterns on the midline of the chest or back. The lesions have a tendency to respond to systemic antimalarial therapy, but novel therapeutic approaches with ultraviolet A1 light (UVA1) and pulse dye laser (PDL) have been promising. Histologically, REM is associated with a mild, predominantly lymphocytic infiltrate with variable deep perivascular extension. Mucin may be seen in the upper and mid dermis and is prominent around the infiltrate and appendages. IgM deposits may be visualized under direct immunoflourescence along the basal layer. Because of the similarities between REM and tumid lupus, the two disease processes have often been grouped together. The remarkable overlap between the two diseases suggests that the two conditions may actually be the same disease.

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“…The mucin gives variable staining reactions. Colloidal iron staining has proven to be better than Alcian blue, which on occasions has yielded false negatives 33,34 …”

Section: Diagnosis/histopathologymentioning

confidence: 99%

Reticular erythematous mucinosis – a review

et al. 2012

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show abstract

“…Mucin deposition has been postulated as a primary aetiological factor. However, there are clinically typical cases without Alcian blue deposition, 2 hence excess mucin may simply represent a secondary phenomenon, 2 and it has been proposed that the name REM should be modified to RE. Increased mucin production may be caused by fibroblast stimulation.…”

Section: Discussionmentioning

confidence: 99%

A pink pruritic eruption

et al. 2006

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“…13.6). 234,235 The material is not usually metachromatic with toluidine blue. 224 A few stellate cells may be present.…”

Section: Histopathologymentioning

confidence: 99%

“…The mucin is most conspicuous around the infiltrate and appendages and within the upper dermis. 235 Staining with colloidal iron and Alcian blue will be negative following digestion with hyaluronidase. The epidermis is usually normal, although mild exocytosis with spongiosis and focal lichenoid inflammation have been reported.…”

Section: Histopathologymentioning

confidence: 99%

Cutaneous mucinoses

Weedon

2010

Weedon's Skin Pathology

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Reticular erythematous mucinosis syndrome*

Cited by 21 publications

References 3 publications

Reticular erythematous mucinosis – a review

Reticular erythematous mucinosis – a review

A pink pruritic eruption

Cutaneous mucinoses

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