Rethinking stress resilience

Bhatnagar, Seema

doi:10.1016/j.tins.2021.09.005

Cited by 39 publications

(22 citation statements)

References 77 publications

(92 reference statements)

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“…While adaptive stress responses are essential for the survival and well-being of all animals, excessive and maladaptive stress responses contribute to the etiology of numerous disorders, including anorexia, depression, and anxiety disorder [ 7 , 9 - 13 ]. As such, considerable effort has been extended in gaining a mechanistic understanding of stress responses, which is still an active research area [ 14 - 23 ].…”

Section: Introductionmentioning

confidence: 99%

Lateral Septum Somatostatin Neurons are Activated by Diverse Stressors

Kim

Park

et al. 2022

Exp Neurobiol

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The lateral septum (LS) is a forebrain structure that has been implicated in a wide range of behavioral and physiological responses to stress. However, the specific populations of neurons in the LS that mediate stress responses remain incompletely understood. Here, we show that neurons in the dorsal lateral septum (LSd) that express the somatostatin gene (hereafter, LSd Sst neurons) are activated by diverse stressors. Retrograde tracing from LSd Sst neurons revealed that these neurons are directly innervated by neurons in the locus coeruleus (LC), the primary source of norepinephrine well-known to mediate diverse stress-related functions in the brain. Consistently, we found that norepinephrine increased excitatory synaptic transmission onto LSd Sst neurons, suggesting the functional connectivity between LSd Sst neurons and LC noradrenergic neurons. However, optogenetic stimulation of LSd Sst neurons did not affect stress-related behaviors or autonomic functions, likely owing to the functional heterogeneity within this population. Together, our findings show that LSd Sst neurons are activated by diverse stressors and suggest that norepinephrine released from the LC may modulate the activity of LSd Sst neurons under stressful circumstances.

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Section: Introductionmentioning

confidence: 99%

Lateral Septum Somatostatin Neurons are Activated by Diverse Stressors

Kim

Park

et al. 2022

Exp Neurobiol

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“…Resilience is defined as the ability to effectively adapt to trauma and/or adversity ( 18 ). Previous studies have shown that people with higher resilience would actively cope with adversity and rapidly adapt to changes ( 19 , 20 ). Meanwhile, resilience partially mediates the correlation between negative life events and the mental health of caregivers of patients with advanced cancers ( 21 ) and diabetes ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

Relationships between care burden, resilience, and depressive symptoms among the main family caregivers of stroke patients: A cross-sectional study

et al. 2022

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ObjectivesThis study aims to explore the potential mediating role of resilience between care burden and depressive symptoms in family caregivers of stroke patients.MethodsA cross-sectional study was conducted with a convenience sample involving 245 main family caregivers of stroke patients recruited from the neurology department of a Tertiary A hospital in China. Mediation analyses were conducted using the PROCESS macro (Model 4) for SPSS, applying the Bootstrap analysis with 5,000 samples and a 95% confidence interval.ResultsThe results showed that with constant hemiplegia side, Barthel Index, education level, monthly income, care time per day, and living with patients in regression equations, the resilience partially mediated the correlation of care burden and depressive symptoms with a mediation effect ratio of 26.32%.ConclusionsResilience plays a mediating role in the correlation between care burden and depressive symptoms.ImpactThe findings indicated a protective effect of resilience in alleviating the negative influences of care burden on depressive symptoms, suggesting that resilience-training intervention may be developed to mitigate depressive symptoms of the main family caregivers of stroke patients.

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“…This mainly involves the motivation component of PMHA. The balance stage emphasizes that police officers calmly respond to the pressure or stimulus of external events, mobilize subjective initiative, tap their own strengths, evaluate their “resilience assets,” 34,35 identify their own emotions, release negative emotions, and reasonably express emotions for active self‐regulation. As a component of mental health ability, the good emotional ability can help individuals to regulate their emotions and adapt to greater work stress, which enables police officers to stabilize their emotions in overloaded law enforcement work, patiently handle cases and parties involved, improve emotional control ability and reduce negative responses to stressful events, so as to prevent emotional, verbal and even behavioral violence in on‐site law enforcement 36–38 .…”

Section: Discussionmentioning

confidence: 99%

Development and validation of police mental health ability scale

Cheng-ju

et al. 2022

Journal of Occupational Health

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Objectives Police officers are generally under long‐term occupational stress. Good mental health ability enables them to better deal with emergencies and enhance their combat effectiveness. We aimed to develop the Police Mental Health Ability Scale (PMHAS) to provide a reference for police selection and ability training. Methods Through literature analysis, individual interviews, half‐open and half‐closed questionnaire surveys, and expert consultations, the components of police mental health ability (PMHA) were theoretically constructed. Then, we enrolled 824 in‐service police officers who participated in the training in Chongqing City and Sichuan Province from November 2018 to January 2019 and recovered 767 valid questionnaires (recovery rate, 93.08%). Results Exploratory factor analysis generated five factors for PMHAS, including cognitive intelligence, emotional catharsis, swift decisiveness, behavioral drive, and reward pursuit, accounting for 58.904% of the variance. Confirmatory factor analysis demonstrated that the model fit well (χ2/df = 1.117, RMSEA = 0.020, GFI = 0.948, CFI = 0.990, IFI = 0.990, TLI = 0.987). The correlation coefficients of factors (r = −0.023 ~ 0.580) were lower than that of each factor and total score (r = 0.477 ~ 0.819). The Cronbach's α coefficients of PMHAS and its factors were 0.606–0.863, and the test–retest reliabilities were 0.602–0.732. Conclusion These results suggest that PMHAS is reliable and valid enough for measuring PMHA, which shows that it is a potentially valuable tool for assessing the mental health ability of police officers.

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Rethinking stress resilience

Cited by 39 publications

References 77 publications

Lateral Septum Somatostatin Neurons are Activated by Diverse Stressors

Lateral Septum Somatostatin Neurons are Activated by Diverse Stressors

Relationships between care burden, resilience, and depressive symptoms among the main family caregivers of stroke patients: A cross-sectional study

Development and validation of police mental health ability scale

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