Retention of dye after indocyanine Green-assisted internal limiting membrane peeling

Ashikari, Masayuki; Ozeki, Hironori; Tomida, Kazuyuki; Sakurai, Eiji; Tamai, Kazushi; Ogura, Yuichiro

doi:10.1016/s0002-9394(03)00074-6

Cited by 45 publications

(20 citation statements)

References 5 publications

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“…[5][6][7][8] In this study we describe the NIR-R, NIR-AF and BW-AF characteristics of choroidal nevi, using confocal scanning laser ophthalmoscope (cSLO), and how these findings correlate to one another.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared reflectance and autofluorescence imaging characteristics of choroidal nevi

Vallabh

Sahni

Parkes

et al. 2016

Eye

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Purpose To report near-infrared reflectance (NIR-R), near-infrared autofluorescence (NIR-AF) and blue wave autofluorescence (BW-AF) appearance of choroidal nevi using a confocal scanning laser ophthalmoscope (cSLO). Patients and methods NIR-R, NIR-AF and BW-AF images of choroidal nevi were compared with color fundus photos (CF). Images were graded as hyperreflective if reflectance was much greater than background, hyporeflective if less than background, and isoreflective if the same as the background. Results Forty-two nevi of 39 patients were imaged. When compared with CF, nevi could be identified on 95% (40/42) NIR-R images (95% CI: 83.5-99.3). On NIR-R 71% (30/42) demonstrated hyperreflectance and 24% (10/42) were hyporeflective. Hyperreflectivity was demonstrated in 96% (23/24) of NIR-AF images (95% CI: 79.1-99.9) and 34% (14/41) of BW-AF images (95% CI: 20.0-50.5). On NIR-R, 29/40 (73%) were apparently smaller in comparison with CF and 11/40 (28%) had the same area. A correlation was found between NIR-R and NIR-AF (P = 0.02) but not with BW-AF (P = 0.15). Conclusions Nevi can be visualized well using NIR-R and NIR-AF imaging modalities, but are less frequently visible using BW-AF. These changes may be related to melanin within the choroid or chronic changes of the overlying retinal pigment epithelium.

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Section: Introductionmentioning

confidence: 99%

Near-infrared reflectance and autofluorescence imaging characteristics of choroidal nevi

Vallabh

Sahni

Parkes

et al. 2016

Eye

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“…This suggested that the hyperfluorescence corresponded to the residual ICG that was used to visualize the ILM, as reported previously. 33 Some retinal capillaries were also accompanied by hyperfluorescence at the same time points (Figure 1). These signals gradually disappeared within a few months postoperatively (Supplementary Figure 1).…”

Section: Characteristics Of Icg Hyperfluorescencementioning

confidence: 85%

“…As ICG has both hydrophilic and lipophilic properties, 36 ICG is believed to bind to lipoproteins and to a lesser extent serum proteins including albumin, and ICG is deposited in the extracellular matrix containing the basement membrane. [36][37][38][39] Well-demarcated ICG hyperfluorescence during the early postoperative phase might represent lipoproteins in the cystoid spaces, 33 whereas it resolved within a few months. In contrast, stardust-like dot hyperfluorescence emerged a few months after vitrectomy, especially at the margin of the retinal vasculature and the optic disc, that seemed to correspond to the ICG phagocytosed by microglia or macrophages.…”

Section: Discussionmentioning

confidence: 99%

“…31,33,34 Briefly, an macular area 30 Â 301 was scanned using an 800-nm filter and excitation with the 787-nm diode laser preoperatively and a minimum of 5 days postoperatively. The images were averaged to improve the signal-to-noise ratio.…”

Section: Icg Fluorescencementioning

confidence: 99%

“…[22][23][24][25][26][27] In addition to the retinal toxicity of ICG, 28 several morphologic patterns of residual ICG several months after vitrectomy performed to treat macular holes have been reported: the area of the macular hole, residual ILM, stardust-like hyperfluorescence especially around the retinal arterioles, and arcuate hyperfluorescence along the nerve fibres from the ganglion cells. [29][30][31][32] Only a few publications have reported the presence of ICG hyperfluorescence in macular oedema associated with retinal vascular diseases, 33,34 although its characteristics are ill-defined and should be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Association between cystoid spaces on indocyanine green hyperfluorescence and optical coherence tomography after vitrectomy for diabetic macular oedema

Yoshitake

Murakami

Uji

et al. 2014

Eye

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Purpose To study retrospectively the characteristics of residual indocyanine green (ICG) fluorescence after ICG-assisted vitrectomy and the association with spectraldomain optical coherence tomography (SD-OCT) findings in diabetic macular oedema (DMO). Methods Thirteen consecutive eyes of 12 patients for whom fundus near-infrared fluorescence and 201 retinal sectional images were obtained using HRA2 and Spectralis OCT, respectively, 5 days after vitrectomy combined with ICG-assisted inner limiting membrane peeling for DMO. The relationship between the characteristics of the ICG hyperfluorescence and the cystoid spaces in the outer plexiform layer (OPL) on SD-OCT images was evaluated. Results A total of 390 well-demarcated areas of ICG hyperfluorescence were delineated on 201 radial OCT scans dissecting the fovea 5 days after vitrectomy. The areas of ICG hyperfluorescence in the parafovea or perifovea were significantly smaller than those at the fovea. Most areas of hyperfluorescence were irregularly shaped in the parafovea and perifovea, whereas 18 of 38 areas of hyperfluorescence were round or oval at the fovea (Po0.001). SD-OCT delineated the cystoid spaces in the OPL in 73 areas of hyperfluorescence that were round or oval and accompanied by dark spots more frequently than that without cystoid spaces on OCT images (Po0.001 and P ¼ 0.002). Of the 123 cystoid spaces in the OPL on OCT images, 44 did not have ICG hyperfluorescence, had lower OCT reflectivity, and contained fewer hyperreflective foci than those with ICG hyperfluorescence (Po0.001 and P ¼ 0.020). Conclusion The results provided novel interpretations of the ICG hyperfluorescence and its association with OCT characteristics of the cystoid spaces in DMO.

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Visual Field Defects After Intravitreous Administration of IndocyanineGreen in Macular Hole Surgery

Kanda

Uemura²,

Yamashita³

et al. 2004

Arch Ophthalmol

104

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Retention of dye after indocyanine Green-assisted internal limiting membrane peeling

Cited by 45 publications

References 5 publications

Near-infrared reflectance and autofluorescence imaging characteristics of choroidal nevi

Near-infrared reflectance and autofluorescence imaging characteristics of choroidal nevi

Association between cystoid spaces on indocyanine green hyperfluorescence and optical coherence tomography after vitrectomy for diabetic macular oedema

Visual Field Defects After Intravitreous Administration of IndocyanineGreen in Macular Hole Surgery

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