Visual Field Defects After Intravitreous Administration of IndocyanineGreen in Macular Hole Surgery

Kanda, Shigeru; Uemura, Akinori; Yamashita, Takehiro; Kita, Hazuki; Yamakiri, Keita; Sakamoto, Taiji

doi:10.1001/archopht.122.10.1447

Cited by 104 publications

(56 citation statements)

References 25 publications

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“…Authors performed ICG washout immediately after or up to 15 s following intravitreal ICG injection. 14,16,27 There are also many reports of visual field defects occurring before the introduction of ICG, with several possible aetiologies including retinal dehydration, elevated intraocular pressure, and direct trauma to the retinal nerve fibre layer or optic nerve.…”

Section: Studies Failing To Show Visual Field Defectsmentioning

confidence: 99%

Vital staining with indocyanine green: a review of the clinical and experimental studies relating to safety

Stanescu-Segall

Jackson

2008

Eye

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Indocyanine green (ICG) is extremely effective when used as a vital stain during macular hole surgery. By staining the internal limiting membrane, ICG facilitates removal of this delicate and sometimes hard to visualize structure. There is, however, considerable debate regarding its safety. This review considers the clinical and experimental studies of ICG and a related agent, infracyanine green. Some clinical papers show visual field defects, reduced visual acuity, and persistence of ICG at the macula and optic nerve. Other clinical studies fail to demonstrate toxicity. The experimental studies are also conflicting, but there are emerging trends. These suggest that surgeons who continue to use ICG should use concentrations not greater than 0.05 mg/ml, in fluid-filled eyes, with short exposure times, iso-osmolar solutions, and avoid proximal or prolonged endoillumination of stained tissue. A smaller number of studies suggest that infracyanine green produces similar staining to ICG, and may possibly be safer, but there are too few well-designed studies to reach a conclusion. Although the use of ICG continues, on the balance of evidence, this review suggests that it is has the potential to produce subtle visual damage.

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Section: Studies Failing To Show Visual Field Defectsmentioning

confidence: 99%

Vital staining with indocyanine green: a review of the clinical and experimental studies relating to safety

Stanescu-Segall

Jackson

2008

Eye

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“…22,25,26,30,32 Among these were OCT studies that identified a reduction in the ganglion cell layer (GCL) following vitrectomy with ICG chromodissection for MHs. 43 Interestingly, another study found no difference in GCL thickness between chromodissection with ICG or Brilliant Blue G. 44 In cases where ultrastructural analysis was performed, no firm conclusions could be reached due to an inability to adequately identify the nature of cellular debris found on excised membranes.…”

Section: Discussionmentioning

confidence: 99%

Inner Retinal Optic Neuropathy: Vitreomacular Surgery-Associated Disruption of the Inner Retina

Pan

Yee

Ross‐Cisneros

et al. 2014

Investigative Ophthalmology & Visual Science

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“…Estos datos coinciden con lo publicado por Engelbrecht et al (24) y Ho et al (25). Asimismo se han descrito defectos campimétricos (19,27) por lesión de la capa de fibras nerviosas que se han relacionado con la creación de un plano de clivaje falso por el ICG (22). Nuestra serie sólo recoge dos pacientes con escotomas.…”

Section: Discussionunclassified

“…Las técnicas, volumen y concentraciones de ICG varían mucho en las distintas series, y todavía no se ha establecido un protocolo internacional al respecto (21). A pesar de que el ICG es comúnmente empleado para la tinción de la MLI, la sospecha de su toxicidad sobre la retina y el epitelio pigmentario de la retina (EPR) ha reabierto el debate sobre su uso (22)(23)(24)(25)(26)(27). A fin de evitar esta toxicidad han surgido nuevas tinciones, como el verde de infracianina (28), el azul tripán (29,30) y la triamcinolona (31).…”

Section: Introductionunclassified

Resultados de la cirugía del agujero macular con diferentes técnicas de tratamiento

Villota-Deleu

Castro-Navarro

González-Castaño

et al. 2006

Arch Soc Esp Oftalmol

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RESUMENObjetivo: Comparar la efectividad, eficiencia y complicaciones de las tres técnicas quirúrgicas empleadas en el tratamiento del agujero macular en el período 1998-2004 en nuestro centro. Métodos: Estudio retrospectivo, comparativo, intervencionista y no aleatorizado de 131 ojos con agujero macular idiopático en estadío III y IV, operados con tres técnicas. En 25 ojos se realizó vitrectomía simple (grupo 1), en 19 ojos se asoció rexis de la membrana limitante interna (MLI) (grupo 2), y en 87 ojos esta rexis se llevó a cabo previa tinción con verde de indocianina (ICG) (grupo 3). Las concentraciones de ICG empleadas fueron del 5%, 2,5% y 0,5%. Se compararon la recuperación anatómica y funcional y las complicaciones en los distintos grupos. Resultados: El 88,4% (114 ojos) lograron la resolución anatómica, siendo superior en el grupo 3 (90,6%). La recuperación funcional se consiguió en el 63,6%. En ambos casos no existieron diferencias entre grupos. Las complicaciones más importantes fueron: cataratas post-cirugía (51,9%), aumento de PIO (37,2%), desprendimientos de retina (7,8%) y alteraciones del epitelio pigmentario (7%). Esta últi-ma se relacionó con el uso de ICG (p<0,05), sin encontrarse diferencias en las concentraciones empleadas. El tamaño del agujero tuvo una correlación inversa con la agudeza visual (AV) inicial y post-qui-ARTÍCULO ORIGINAL ABSTRACT Purpose: To compare the effectiveness, efficiency and complications of three different surgical techniques employed for the treatment of macular holes between 1998 -2004 in our health care centre. Methods: A retrospective, comparative, and nonrandomized study of 131 eyes with macular holes, stage III and IV, treated with three different surgical techniques was performed. Vitrectomy was performed in 25 eyes (group 1). Vitrectomy was associated with internal limiting membrane peeling in 19 eyes (group 2), and in the remaining 87 eyes, the peeling of the retinal internal limiting membrane was assisted with indocyanine green (ICG) (group 3). The concentrations of ICG used were 5%, 2.5% and 0.5%. We compared the anatomic and functional results, and the complications which occurred. Results: The overall anatomic success rate was 88.4% (114 eyes), and it was higher in group 3 (90.6%). A visual acuity improvement was achieved in 63.6% of eyes; however there were no significant differences between the groups studied. The most important complications included cataracts (51.9%), increase in intra-ocular pressure (37.2%), retinal detachment (7.8%) and retinal pigment epithelial changes (7%). These pigment epithelial changes were associated with the use of ICG-assisted peeling (p<0.05), but there was no correlation between the changes and the concentration of ICG

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Visual Field Defects After Intravitreous Administration of IndocyanineGreen in Macular Hole Surgery

Cited by 104 publications

References 25 publications

Vital staining with indocyanine green: a review of the clinical and experimental studies relating to safety

Vital staining with indocyanine green: a review of the clinical and experimental studies relating to safety

Inner Retinal Optic Neuropathy: Vitreomacular Surgery-Associated Disruption of the Inner Retina

Resultados de la cirugía del agujero macular con diferentes técnicas de tratamiento

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