Resveratrol Trimers from Seed Cake of Paeonia rockii

Liu, Pu; Wang, Yiran; Gao, Jiayu; Lu, Zongyuan; Yin, Weiping; Deng, Ruixue

doi:10.3390/molecules191219549

Cited by 20 publications

(19 citation statements)

References 8 publications

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“…Stilbenoids are very typical polyphenols in our diets, which mainly present in red grapes, wines, cranberries, strawberries, and peanuts [ 118 , 119 ]. Resveratrol and its derivatives are the most important dietary stilbenoids associated with many benefits for human health [ 120 , 121 , 122 ]. trans -Resveratrol is metabolized by human gut microbiota to dihydroresveratrol, 3,4′-dihydroxy-trans-stilbene and 3,4′-dihydroxybibenzyl (lunularin) in vivo [ 123 ].…”

Section: Metabolism Of Phenolics and Microbial/colonic Metabolic Pmentioning

confidence: 99%

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

et al. 2016

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As of late, polyphenols have increasingly interested the scientific community due to their proposed health benefits. Much of this attention has focused on their bioavailability. Polyphenol–gut microbiota interactions should be considered to understand their biological functions. The dichotomy between the biotransformation of polyphenols into their metabolites by gut microbiota and the modulation of gut microbiota composition by polyphenols contributes to positive health outcomes. Although there are many studies on the in vivo bioavailability of polyphenols, the mutual relationship between polyphenols and gut microbiota is not fully understood. This review focuses on the biotransformation of polyphenols by gut microbiota, modulation of gut microbiota by polyphenols, and the effects of these two-way mutual interactions on polyphenol bioavailability, and ultimately, human health.

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Section: Metabolism Of Phenolics and Microbial/colonic Metabolic Pmentioning

confidence: 99%

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

et al. 2016

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“…The earlier mentioned results showed that the seven oligostilbenes were the majority of the total oligostilbenes, and could be used to evaluate the content of the main oligostilbenes in the seed shell of P. ostii . Oligostilbenes were considered to be the characteristic component in the seed shell of genus Paeonia with a wide range of biological activities . Therefore, for the first time the content of the seven oligostilbenes in the seed shell of P. ostii were simultaneously determined in this study.…”

Section: Resultsmentioning

confidence: 99%

“…Then the seed shell was ground into a powder, packed in separate glass containers and stored at −4°C for future use. Seven oligostilbene standards (Figure ), including oligostilbenes, suffruticosol A, suffruticosol B, suffruticosol C, cis ‐ ε ‐viniferin, trans ‐ ε ‐viniferin, cis ‐gnetin and trans ‐gnetin, were isolated and purified from an ethanol extract of P. ostii seed shell, and their structures were identified by comparing their spectroscopic data with those reported in the literature . The purity of each reference was determined to be over 98% by normalisation of the peak areas detected by HPLC‐DAD.…”

Section: Methodsmentioning

confidence: 99%

“…According to the earlier data, approximately more than 225000 tons of peony seed shells will be produced each year in the process of preparing peony seed oil. The phytochemical and bioactivities studies on the oil peony seed shell has led to the isolation and identification of oligostilbenes with antioxidant, antibacterial and antitumour activities . As relatively new natural products with rare polymer skeletons, oligostilbenes have attracted intense interest because of their intricate structures and diverse biological activities.…”

Section: Introductionmentioning

confidence: 99%

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Profiling and simultaneous quantitative determination of oligostilbenes in Paeonia ostii seed shell from different geographical areas in China and their comparative evaluation

Zhang

Liu

Gao

et al. 2019

Phytochemical Analysis

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Introduction The Paeonia ostii T. Hong & J. X. Zhang seed shell, characterised by a high content of oligostilbenes, is one of the two most important by‐products in the preparation of seed oil. Oligostilbenes are considered characteristic constituents of the genus Paeonia, and can be used in fingerprinting to determine the geographical origin and the quality of raw materials. Objective To develop and optimise a simple and reproducible high‐performance liquid chromatography diode array detection (HPLC‐DAD) method for the simultaneous determination of seven oligostilbenes in P. ostii seed shell from different geographical areas, and to associate the cultivation area. Methodology A validated HPLC method coupled with a DAD detector was performed for the detection and determination of target compounds in the samples. Optimal chromatographic conditions were achieved using an Agilent Zorbax Eclipse SB‐AQ‐C18 column and a gradient elution with acetonitrile and potassium dihydrogen phosphate solution. Results The proposed quantitative method showed appropriate accuracy and precision, and was successfully applied to the routine analysis of seven oligostilbenes and the quality evaluation of 50 P. ostii seed shell samples. There were significant differences between the contents of the seven oligostilbenes in different samples (P < 0.01). Conclusion The results demonstrated that the oligostilbenes were main secondary metabolites in the P. ostii seed shells, and the content of seven components in P. ostii seed shells sourced from different cultivation areas in China was different.

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“…[5].Several stilbenoids compounds including gnetin H(1) ; trans-ε-viniferin(2) and cis--viniferin (3) have been isolated from the seed cakes of Paeonia, meanwhile we also described the activity-guided isolation of the EtOAc extract in the previous studyreported. [6][7]. Oligostilbenoids compounds with antimicrobial properties have attracted great interest in recent times as a result against Gram-positive bacteria.…”

Section: Introductionmentioning

confidence: 99%

Oligostilbenoids Investigation of Structure-Activity Relationship with Chemical Biology Information

Yin

Liu

et al. 2015

2015 Seventh International Conference on Measuring Technology and Mechatronics Automation

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The present study was to isolate oligostilbenoids with anti-MRSA activity from the seed cake of Paeonia in Luoyang ,China. In the screening program for natural bioactive compounds that enhance the expression of a minimal inhibitory concentration (MIC) value of the tested compounds against Methicillin-resistant staphylococcus aureus, and the exploration of their structure-activity relationship . The MIC of the purified molecule Gnetin H was 0.059mg/mL and Trans-ε-viniferin was 0.118mg/mL. Activity-guided fractionation of the seed cake of Paeonia EtOAc extract led to the isolation of three oligostilbenoids (1-3), and revealed the antibacterial activity of stilbenoids associated with the structure of phenol polymerization degree.

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Resveratrol Trimers from Seed Cake of Paeonia rockii

Cited by 20 publications

References 8 publications

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

Profiling and simultaneous quantitative determination of oligostilbenes in Paeonia ostii seed shell from different geographical areas in China and their comparative evaluation

Oligostilbenoids Investigation of Structure-Activity Relationship with Chemical Biology Information

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