Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity

Kim, Sujin; Kim, Won-Ki; Kim, Do-Hee; Jang, Ja Young; Kim, Su-Jung; Park, Sin-Aye; Hahn, Hyunggu; Han, Byung Woo; Na, Hye-Kyung; Chun, Kyung‐Soo; Choi, Bu Young; Surh, Young‐Joon

doi:10.1016/j.abb.2020.108413

Cited by 38 publications

(22 citation statements)

References 39 publications

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“…In addition, an in vivo study manifested that resveratrol suppressed ovarian cancer growth and liver metastasis in the xenograft mouse model [53]. In another study, resveratrol could inhibit cell growth and proliferation in human gastric cancer SNU-601 cells by suppressing the activity of proviral integration site for Moloney murine leukemia virus-1 (PIM-1) kinase [54].…”

Section: Effect Of Resveratrol On Cancersmentioning

confidence: 99%

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Zhou

Luo

Huang

et al. 2021

Oxidative Medicine and Cellular Longevity

156

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The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. In this review, we summarize the effects of resveratrol on aging, life extension, and several age-related diseases, with special attention paid to the mechanisms of antiaging action.

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Section: Effect Of Resveratrol On Cancersmentioning

confidence: 99%

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Zhou

Luo

Huang

et al. 2021

Oxidative Medicine and Cellular Longevity

156

View full text Add to dashboard Cite

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“…Resveratrol inhibits PIM-1 activity via binding to the ATP pocket, reducing cancer cell proliferation and survival. 82 …”

Section: Results and Discussionmentioning

confidence: 99%

Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile

et al. 2022

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A series of latonduine and indoloquinoline derivatives HL 1 – HL 8 and their copper(II) complexes ( 1–8 ) were synthesized and comprehensively characterized. The structures of five compounds ( HL 6 , [CuCl(L 1 )(DMF)]·DMF , [CuCl(L 2 )(CH 3 OH)] , [CuCl(L 3 )]·0.5H 2 O , and [CuCl 2 (H 2 L 5 )]Cl·2DMF ) were elucidated by single crystal X-ray diffraction. The copper(II) complexes revealed low micro- to sub-micromolar IC 50 values with promising selectivity toward human colon adenocarcinoma multidrug-resistant Colo320 cancer cells as compared to the doxorubicin-sensitive Colo205 cell line. The lead compounds HL 4 and 4 as well as HL 8 and 8 induced apoptosis efficiently in Colo320 cells. In addition, the copper(II) complexes had higher affinity to DNA than their metal-free ligands. HL 8 showed selective inhibition for the PIM-1 enzyme, while 8 revealed strong inhibition of five other enzymes, i.e., SGK-1, PKA, CaMK-1, GSK3β, and MSK1, from a panel of 50 kinases. Furthermore, molecular modeling of the ligands and complexes showed a good fit to the binding pockets of these targets.

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“…Res, the predominant active component of Polygonum cuspidatum , has been demonstrated to provide beneficial effects in various human diseases such as cancers and fibrotic diseases [ 26 ]. For example, Res suppresses the survival and proliferation of gastric cancer cells via the inactivation of PIM-1 kinase activity [ 27 ]. Zou et al demonstrated that Res can attenuate cardiac fibrosis via the PTEN/AKT/Smad2/3 and NF- κ B pathways [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway

Zhang

Zhan

et al. 2021

Mediators of Inflammation

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Liver fibrosis, which results from chronic liver injury due to factors such as chronic alcohol consumption, hepatitis virus infections, and immune attacks, is marked by excessive deposition of extracellular matrix (ECM). Resveratrol (Res), a polyphenol phytoalexin, has been demonstrated to show anti-inflammatory, antioxidative, antiproliferative, and chemopreventive activities. In recent years, Res has been found to inhibit liver fibrosis. Enhanced Hippo pathway activation has also been reported to inhibit tumor progression and liver fibrosis. In the present study, the role of the Hippo pathway in mediating the effects of Res on hepatic stellate cells (HSCs) was examined. We found that Res significantly suppresses HSC proliferation, reducing the cell index. Res induced HSC inactivation, reducing collagen deposition and α-smooth muscle actin (α-SMA) expression. In addition, Res contributed to HSC apoptosis, upregulating Bax and downregulating Bcl-2 expression. Notably, the Hippo pathway was involved in the Res-mediated suppression of HSC activation. Res enhanced the activation of the Hippo pathway and reduced yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) expression. Interestingly, the YAP overexpression inhibited Res-induced HSC inactivation and apoptosis. In conclusion, these results demonstrate that Res inhibits HSC activation, at least in part, via the Hippo pathway. The present study indicates a new antifibrotic mechanism of Res and provides novel insights into Hippo-mediated HSC apoptosis and HSC activation in liver fibrosis.

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Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity

Cited by 38 publications

References 39 publications

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile

Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway

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