Resveratrol reverses the effect of TNF-α on inflammatory markers in a model of autoimmune uveitis

Olive Pomace Phenolic Compounds and Extracts Can Inhibit Inflammatory- and Oxidative-Related Diseases of Human Ocular Surface Epithelium

“…Granner et al [30], Zhu et al [32], and Liu et al [33] used safely HT up to 100 µM in retinal pigment epithelial cells, while Zou et al [31] proved the antioxidant effect of HT in the same cell line up to 200 µM. Abengózar-Vela et al [13] showed that resveratrol is nontoxic up to 300 µM for ocular surface epithelial cells, while for Paladino et al [42], resveratrol can be safely used up to 200 µM for retinal epithelial cells. Stoddard et al [43] studied the antioxidant activity of four different polyphenols (quercetin, n-propyl gallate, epigallocatechin gallate (EGCG), and gallic acid) in human corneal cells and demonstrated that their toxic concentrations could vary from 41.3 to 337.5 µM, depending on the compound.…”

Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

“…Polyphenols are nowadays considered potential antiaging agents because of their ability to modulate oxidative damage, inflammation, cell senescence and autophagy (Russo et al, 2020). RSV is not only useful reducing the levels of TNFα in aged animals (Tung et al, 2015), it also reduces the effect of TFNα in an in vitro model of uveitis in which reduces the response to TNFα and the release of proinflammatory cytokines (Paladino et al, 2020). A recent revision about the effect of different compounds on chronic low grade inflammation in humans and model animals indicated that RSV and metformin, a widely used pharmacological compound for T2DM treatment, show anti-inflammatory capacity and can be considered promising therapies for inflammation and frailty in the elderly (Chen et al, 2019).…”