Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat diet in mice

Sun, Lirui; Wang, Yan; Song, Yu; Cheng, Xiang‐Rong; Xia, Shufang; Rahman, Ramim Tanver; Shi, Yonghui; Li, Guowei

doi:10.1016/j.bbrc.2015.01.072

Cited by 93 publications

(70 citation statements)

References 33 publications

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“…Moreover, resveratrol feeding (0.1% in diet) also attenuated HFDinduced obesity and weight gain in mice models by normalizing the nearly flat daily circadian rhythms of Per2, Clock, and Bmal1 gene expression (Sun et al, 2015). These studies confirm that the circadian rhythm is one of the targets of the beneficial effect of resveratrol.…”

Section: Resveratrol and Sirt1 Interaction In Orchestrating Circadisupporting

confidence: 54%

The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols

Man

Xia

Daiber

et al. 2019

British J Pharmacology

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Polyphenols are secondary metabolites of plants that have been widely studied for their health benefits as antioxidants. In the last decade, several clinical trials and epidemiological studies have shown that long‐term consumption of polyphenol‐rich diet protects against chronic diseases such as cancers and cardiovascular diseases. Current cardiovascular studies have also suggested an important role of gut microbiota and circadian rhythm in the pathogenesis metabolic and cardiovascular diseases. It is known that polyphenols can modulate the composition of core gut microbiota and interact with circadian clocks. In this article, we summarize recent findings, review the molecular mechanisms and the potential of polyphenols as dietary supplements for regulating gut microbiota and circadian rhythms, and discuss future research directions. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Section: Resveratrol and Sirt1 Interaction In Orchestrating Circadisupporting

confidence: 54%

The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols

Man

Xia

Daiber

et al. 2019

British J Pharmacology

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“…recently, in order to alleviate circadian clock-related disease, there has been significant progress in the development of chemical compounds which are capable of manipulating clock genes as novel preventive and therapeutic agents (29). For example, resveratrol, which is considered a natural antioxidant polyphenol compound, has also been demonstrated to ameliorate circadian disorders of lipid metabolism (30). Moreover, a recent study revealed that glucocorticoids altered the circadian clock in the iris-ciliary body in a mouse model (31).…”

Section: Discussionmentioning

confidence: 99%

Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling

Huang

Wei

et al. 2020

Mol Med Report

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increasing research has demonstrated that expression of brain and muscle arnT-like 1 (BMal1) and other circadian clock genes can be regulated by drugs and toxicants. We previously demonstrated that icariin, extracted from Herba epimedii, sromotes osteogenic differentiation. However, the mechanism underlying the association between icariin and BMal1 in osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMScs) remains unclear. The present study was designed with an aim to clarify the association between icariin and BMal1 in osteogenic differentiation of BMScs. The cell counting Kit-8 assay was used to evaluate cell proliferation. The expression of bone morphogenetic protein 2 (BMP2), runX family transcription factor 2 (runX2), alkaline phosphatase (alP), osteocalcin (oc) and BMal1 in BMScs was evaluated by reverse transcription-quantitative Pcr and western blotting. alP and alizarin red S (arS) staining were also performed. icariin promoted BMSc proliferation, and upregulated expression of osteogenic genes and BMal1. in addition, expression of the osteogenic genes BMP2, runX2, alP and oc were upregulated by BMal1 overexpression. Furthermore, we confirmed that BMal1 deficiency suppressed osteogenic differentiation in BMScs. Finally, arS staining of BMal1 -/-BMScs revealed that BMal1 was an essential intermediary in matrix mineralization during osteogenic differentiation. in conclusion, these results demonstrated that icariin promoted osteogenic differentiation through BMal1-BMP2 signaling in BMScs. The present study thus described a novel target of icariin that has potential applications in the treatment of osteogenic disorders.

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“…Podrbasky and Somero (2004) tested the effect of a diel thermal cycle relative to constant temperature on liver gene expression in fish and found temperature regime to affect expression of hundreds of genes including those involved in energy metabolism. The compound resveratrol is known to extend lifespan in some rodent models (Barger and others 2008), and is also know to regulate circadian rhythms at the cellular level (Sun and others 2015). Intriguingly, Kim and others (2014) found that resveratrol does not affect lifespan in D. pulex , but it did delay time to reproduction and reduced early life reproduction in a similar pattern to fluctuating temperatures in our study.…”

Section: Discussionmentioning

confidence: 99%

Effects of fluctuating temperature and food availability on reproduction and lifespan

Schwartz

Pearson

Dawson

et al. 2016

Experimental Gerontology

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Experimental studies on energetics and aging often remove two major factors that in part regulate the energy budget in a normal healthy individual: reproduction and fluctuating environmental conditions that challenge homeostasis. Here we use the cyclical parthenogenetic Daphnia pulex to evaluate the role of a fluctuating thermal environment on both reproduction and lifespan across six food concentrations. We test the hypotheses that (1) caloric restriction extends lifespan; (2) maximal reproduction will come with a cost of shortened lifespan; and (3) at a given food concentration, relative to a metabolically equivalent constant temperature environment a diel fluctuating thermal environment will alter the allocation of energy to reproduction and lifespan to maintain homeostasis. We did not identify a level of food concentration that extended lifespan in response to caloric restriction, and we found no cost of reproduction in terms of lifespan. Rather, the individuals at the highest food levels generally had the highest reproductive output and the longest lifespans, the individuals at the intermediate food level decreased reproduction and maintained lifespan, and the individuals at the three lower food concentrations had a decrease in reproduction and lifespan as would be predicted with increasing levels of starvation. Fluctuating temperature had no effect on lifespan at any food concentration, but delayed time to reproductive maturity and decreased early reproductive output at all food concentrations. This suggests that a fluctuating temperature regimen activates molecular pathways that alter energy allocation. The costs of fluctuating temperature on reproduction were not consistent across the lifespan. Statistical interactions for age of peak reproduction and lifetime fecundity suggest that senescence of the reproductive system may vary between temperature regimens at the different food concentrations.

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Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat diet in mice

Cited by 93 publications

References 33 publications

The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols

The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols

Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling

Effects of fluctuating temperature and food availability on reproduction and lifespan

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