Resveratrol regulates lipolysis via adipose triglyceride lipase

Lasa, Arrate; Schweiger, Martina; Kotzbeck, Petra; Churruca, Itziar; Simón, Edurne; Zechner, Rudolf; Portillo, María del Puy

doi:10.1016/j.jnutbio.2010.12.014

Cited by 117 publications

(97 citation statements)

References 30 publications

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“…Our study revealed distinct and much more dynamic actions of resveratrol on both high-fat diet obese mice and 3T3-L1 cells conferred by a wide range of concentrations, as compared to previous studies [35][36][37][38][39][40][41]. At low concentrations (below 10 μM), resveratrol appears to inhibit adipogenic differentiation and lipolysis.…”

Section: Discussionsupporting

confidence: 57%

“…The effects of resveratrol on lipolysis have been studied in vitro, ex vivo, and in vitro [40,41]. One study demonstrated that resveratrol (100 μM) failed to promote lipolysis in epididymal adipocytes of rat [40].…”

Section: Discussionmentioning

confidence: 99%

“…One study demonstrated that resveratrol (100 μM) failed to promote lipolysis in epididymal adipocytes of rat [40]. Another study suggested that treatment of resveratrol (100 μM) for 12, 24, or 48 hr significantly promoted lipolysis in 3T3-L1 adipocytes and also exerted synergistic action with epinephrine [41]. It is not clear whether this discrepancy is due to differential response of rat epididymal adipocytes versus 3T3-L1 cells.…”

Section: Discussionmentioning

confidence: 99%

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Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells

et al. 2016

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells

et al. 2016

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“…In vitro experiments also indicated that ginkgolide B could significantly enhance Sirt-1 production, and oleic acid-induced hepatocytes treated with 10 μM ginkgolide B for 2-4 h showed significantly increased pAMPK levels. Resveratrol is a Sirt-1 inducer and can enhance the expression of Sirt-1 and pAMPK in fatty liver of HFD mice for anti-obesity and improved NAFLD effects [43]. Resveratrol also activates phosphorylation of ACC, which is the most important regulatory enzyme in fatty acid synthesis [44].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Ginkgolide B reduces hepatic lipid accumulation and ameliorates nonalcoholic fatty liver disease in high-fat dietâ€“induced obese mice

Wang¹,

Liou²,

Wu³

et al. 2018

Oncotarget

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Ginkgolide B is isolated from Ginkgo biloba leaves. It has multiple biological functions, including alleviating lung injury and ischemic stroke in mice and protecting pancreatic beta cells and improving endothelial dysfunction in diabetic mice. Here we sought to determine whether ginkgolide B ameliorates nonalcoholic fatty liver disease (NALFD) in high-fat diet (HFD)-induced obese mice. We also evaluated whether or not ginkgolide B reduces lipid accumulation of hepatocytes in vitro. C57BL/6 mice were fed with HFD and treated with ginkgolide B by intraperitoneal injection twice a week for last 10 weeks of the 14-week HFD feeding period. In addition, HepG2 cells were treated with oleic acid to establish a fatty liver cell model and exposed to various concentrations of ginkgolide B. Ginkgolide B significantly decreased hepatic lipid accumulation and alleviated steatosis in HFD-induced obese mice. It also reduced body weight and epididymal adipose tissue weight. Serum assay results showed that ginkgolide B inhibited leptin, alanine aminotransferase, and aspartate aminotransferase levels and increased HDL levels compared to obese mice. It also decreased fatty acid synthase expression and increased Sirt-1 and phosphorylation of AMP-activated protein kinase α in liver tissue. Furthermore, ginkgolide B significantly inhibited lipid accumulation and expression of adipogenesis-related proteins and increased adipolysis-associated protein expression in hepatocytes in vitro. These results suggest that ginkgolide B is an effective natural compound for alleviating hepatic lipid accumulation and reducing body weight in obese mice. It also ameliorated NALFD in HFD-induced obese mice. www.impactjournals.com/oncotarget/

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“…At present, we do not have a clear explanation for these results taking into account the activating lipolytic actions of phlorotannins [31,32,33]. Lasa et al [34] found that resveratrol increased fatty acid release in epididymal adipose tissue of wild-type and HSL knockout mice. The decrease of HSL expression in SS versus C rats seems a probable counterbalance mechanism to avoid excessive losses of body weight and adipose tissue weight and fat in SS animals.…”

Section: Discussionmentioning

confidence: 98%

Effects of Restructured Pork Containing <b><i>Himanthalia elongata</i></b> on Adipose Tissue Lipogenic and Lipolytic Enzyme Expression of Normo- and Hypercholesterolemic Rats

González‐Torres¹,

Churruca

Moreira³

et al. 2012

Lifestyle Genomics

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Background: Inclusion of seaweeds in restructured pork (RP) would improve meat health properties. Aim: The aim was to determine the effects of RP containing Himanthalia elongata on growth, organ weight, cholesterolemia, and expression of lipoprotein lipase (LPL), acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), and hormone-sensitive lipase (HSL) in adipose tissue of Wistar rats. Methods: The control group (C) consumed control RP, and the seaweed group (SS) consumed RP with 5% Himanthalia elongata. Animals on cholesterol-enriched diets (CholC, CholSS) consumed their corresponding basal diets with supplementary cholesterol (2.43%) plus cholic acid (0.49%) as hypercholesterolemic agents. Results: Seaweed inclusion did not modify cholesterolemia but reduced (p < 0.01) the hypercholesterolemic effect of dietary cholesterol plus cholic acid. CholC rats presented lower (p < 0.05) adipose fat and weight than C rats. Cholesterol feeding affected HSL, ACC, and FAS expression (p < 0.05), while alga consumption influenced HSL and ACC (p < 0.05). LPL was not significantly affected by both factors. CholSS rats showed decreased HSL and FAS (p < 0.05) but increased ACC (p < 0.05) expression compared with CholC rats. Conclusion:Himanthalia RP partially blocked the dietary hypercholesterolemic effect and changed the lipogenic/lipolytic enzyme expression, reducing the wasting effect of hypercholesterolemia on adipose tissue in rats.

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Resveratrol regulates lipolysis via adipose triglyceride lipase

Cited by 117 publications

References 30 publications

Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells

Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells

WITHDRAWN: Ginkgolide B reduces hepatic lipid accumulation and ameliorates nonalcoholic fatty liver disease in high-fat dietâ€“induced obese mice

Effects of Restructured Pork Containing <b><i>Himanthalia elongata</i></b> on Adipose Tissue Lipogenic and Lipolytic Enzyme Expression of Normo- and Hypercholesterolemic Rats

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