Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial

Sattarinezhad, Azar; Roozbeh, Jamshid; Yeganeh, Babak Shirazi; Omrani, Gholamhossein Ranjbar; Shams, Mesbah

doi:10.1016/j.diabet.2018.05.010

Cited by 99 publications

(87 citation statements)

References 24 publications

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“…Yılmaz and others (Yılmaz et al, 2017) has shown that administration of resveratrol in drinking water to chronic MG-treated rats significantly reduces the level of advanced oxidation protein products (AOPP), AGEs, and protein carbonyl in plasma, as well as markers of oxidative stress in the liver. A significant decrease in urine albumin and creatinine and an increase in serum antioxidant enzymes were also observed in patients with type II diabetes and diabetic nephropathy who received resveratrol at the dose of 500 mg per day (Sattarinezhad et al, 2018). Resveratrol prevents opacification and formation of polyols in the bovine lens, as well as ameliorates kidney function due to suppression of AGEs formation, suggesting that resveratrol may be considered as a protective agent against diabetic complications such as cataracts and nephropathy (Ciddi & Dodda, 2014;Hussein & Mahfouz, 2016).…”

Section: Introductionmentioning

confidence: 92%

Health benefits of resveratrol administration

Aebisher²,

2019

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Resveratrol is a polyphenol which is abundant in grape skin and seeds. Sources of resveratrol in food also include wine, berries, and peanuts. This compound displays many properties including activity against glycation, oxidative stress, inflammation, neurodegeneration, several types of cancer, as well as aging. Due to the fact that resveratrol is generally well-tolerated, it is believed to be a promising compound in preventing many diseases such as diabetes and associated complications. Unfortunately, this compound exhibits low bioavailability and solubility. The aim of this review is to summarize recent information from in vitro and in vivo studies on animals and humans on the multiple effects of resveratrol on health and benefits of its intake.

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Section: Introductionmentioning

confidence: 92%

Health benefits of resveratrol administration

Aebisher²,

2019

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“…Oxyresveratrol (2′,3,4′,5-tetrahydroxystilbene), found in white mulberry ( Morus alba ), exhibited, among other effects, the inhibition of TNF-α production and stronger antioxidant activity than resveratrol [14]. Many of these molecules have been subjected to clinical trials and are being investigated as clinical drugs [15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Metabolism of Stilbenoids by Human Faecal Microbiota

et al. 2019

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Stilbenoids are dietary phenolics with notable biological effects on humans. Epidemiological, clinical, and nutritional studies from recent years have confirmed the significant biological effects of stilbenoids, such as oxidative stress protection and the prevention of degenerative diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases. Stilbenoids are intensively metabolically transformed by colon microbiota, and their corresponding metabolites might show different or stronger biological activity than their parent molecules. The aim of the present study was to determine the metabolism of six stilbenoids (resveratrol, oxyresveratrol, piceatannol, thunalbene, batatasin III, and pinostilbene), mediated by colon microbiota. Stilbenoids were fermented in an in vitro faecal fermentation system using fresh faeces from five different donors as an inoculum. The samples of metabolized stilbenoids were collected at 0, 2, 4, 8, 24, and 48 h. Significant differences in the microbial transformation among stilbene derivatives were observed by liquid chromatography mass spectrometry (LC/MS). Four stilbenoids (resveratrol, oxyresveratrol, piceatannol and thunalbene) were metabolically transformed by double bond reduction, dihydroxylation, and demethylation, while batatasin III and pinostilbene were stable under conditions simulating the colon environment. Strong inter-individual differences in speed, intensity, and pathways of metabolism were observed among the faecal samples obtained from the donors.

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“…These results are in accordance with the results obtained by Teixeira [118] and Yang [119], who also observed a decrease in the UACR levels through administration of flavonoids in T2D patients. A later study performed by Sattarinezhad [120] also showed a decrease in the UACR when administering resveratrol. A meta-analysis performed by Liu et al [121] showed the potential renal protective effects of breviscapine (flavonoid of Erigeron breviscapus) injections, reducing urine protein, serum creatinine and blood urea nitrogen in DN patients.…”

Section: Diabetic Nephropathymentioning

confidence: 86%

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Caro-Ordieres

Marín-Royo

Opazo-Ríos

et al. 2020

JCM

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Diabetes mellitus (DM), and its micro and macrovascular complications, is one of the biggest challenges for world public health. Despite overall improvement in prevention, diagnosis and treatment, its incidence is expected to continue increasing over the next years. Nowadays, finding therapies to prevent or retard the progression of diabetic complications remains an unmet need due to the complexity of mechanisms involved, which include inflammation, oxidative stress and angiogenesis, among others. Flavonoids are natural antioxidant compounds that have been shown to possess anti-diabetic properties. Moreover, increasing scientific evidence has demonstrated their potential anti-inflammatory and anti-oxidant effects. Consequently, the use of these compounds as anti-diabetic drugs has generated growing interest, as is reflected in the numerous in vitro and in vivo studies related to this field. Therefore, the aim of this review is to assess the recent pre-clinical and clinical research about the potential effect of flavonoids in the amelioration of diabetic complications. In brief, we provide updated information concerning the discrepancy between the numerous experimental studies supporting the efficacy of flavonoids on diabetic complications and the lack of appropriate and well-designed clinical trials. Due to the well-described beneficial effects on different mechanisms involved in diabetic complications, the excellent tolerability and low cost, future randomized controlled studies with compounds that have adequate bioavailability should be evaluated as add-on therapy on well-established anti-diabetic drugs.

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Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial

Cited by 99 publications

References 24 publications

Health benefits of resveratrol administration

Health benefits of resveratrol administration

Metabolism of Stilbenoids by Human Faecal Microbiota

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

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