Resveratrol prevents bradykinin-induced contraction of rat urinary bladders by decreasing prostaglandin production and calcium influx

Tsuda, Yo; Nakahara, Tsutomu; Mori, Akira; Sakamoto, Kenji; Ishii, Kunio

doi:10.1016/j.ejphar.2011.05.019

Cited by 11 publications

(12 citation statements)

References 29 publications

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“…The contractile responses to 5-HT via the 5-HT 2A receptor in the BOO rat bladder were potent, since the maximum contractile responses to 5-HT were ϳ40% of those for the cholinergic responses. Additionally, the contractile responses to 5-HT were quite potent compared with those for other bladder contracting factors, such as ATP, PGE 2 , and phenylephrine (4,43). Furthermore, it has been reported that there is an increased contractility in response to 5-HT in aged or diabetic rat bladder (24,38).…”

Section: Discussionmentioning

confidence: 95%

5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT_2Areceptor in partial bladder outlet obstruction in rats

Sakai

Kasahara

Tomita

et al. 2013

American Journal of Physiology-Renal Physiology

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We investigated the effects of partial bladder outlet obstruction (BOO) on the function and gene expression of 5-hydroxytryptamine (5-HT) receptor subtypes in rat bladder. Isometric contractions of the isolated bladders from sham-operated control and BOO rats were examined. The contractile responses to 5-HT were significantly increased in BOO rat bladder strips, while the responses to KCl, carbachol, or phenylephrine were not different from the control. The 5-HT-induced hypercontraction in BOO rat bladder strips was inhibited by ketanserin, a 5-HT(2A) receptor antagonist. The contractile responses to 5-HT in bladder strips were not affected by urothelium removal from the intact bladder. The gene expression of 5-HT receptor subtypes in the bladders was analyzed by RT-PCR. The mRNA expression of the 5-HT(2A), 5-HT(2B), 5-HT(2C), 5-HT(4), and 5-HT(7) receptors was detected in both the control and BOO rat bladders. Quantitative RT-PCR analysis showed there was a significant increase of 5-HT(2A) receptor mRNA in the BOO rat bladder compared with the control bladder. On the other hand, the gene expression of the 5-HT(4) receptor was not changed in the BOO rat bladder. These results suggest that the increased contractile responses to 5-HT in BOO rat bladder may be partly caused by 5-HT(2A) receptor upregulation in the detrusor smooth muscles.

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Section: Discussionmentioning

confidence: 95%

5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT_2Areceptor in partial bladder outlet obstruction in rats

Sakai

Kasahara

Tomita

et al. 2013

American Journal of Physiology-Renal Physiology

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“…In the soleus muscle of resveratrol-treated monkeys, mRNA and protein MHC isoforms were similarly distributed to that in control (Con-Y and -O) monkeys, suggesting that resveratrol may have reversed, or blunted, the slow to fast shift that was evident in the HFS group. The mechanism of action of resveratrol is not entirely understood, but several studies report a resveratrol-specific influence on calcium homeostasis or Ca 2+ -mediated signaling (Shtifman et al, 2011 ; Tsuda et al, 2011 ), suggesting that resveratrol may be modulating type I MHC expression by emulating slow Ca 2+ dynamics. Alternatively, resveratrol may counteract the high fat/sugar changes on the neural system and normalize activity, although this is less likely given that diet-mediated changes on the plantaris muscle were not observed.…”

Section: Discussionmentioning

confidence: 99%

Muscle-Specific Myosin Heavy Chain Shifts in Response to a Long-Term High Fat/High Sugar Diet and Resveratrol Treatment in Nonhuman Primates

et al. 2016

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Shifts in myosin heavy chain (MHC) expression within skeletal muscle can be induced by a host of stimuli including, but not limited to, physical activity, alterations in neural activity, aging, and diet or obesity. Here, we hypothesized that both age and a long-term (2 year) high fat/high sugar diet (HFS) would induce a slow to fast MHC shift within the plantaris, soleus, and extensor digitorum longus (EDL) muscles from rhesus monkeys. Furthermore, we tested whether supplementation with resveratrol, a naturally occurring compound that has been attributed with augmenting aerobic potential through mitochondrial proliferation, would counteract any diet-induced MHC changes by promoting a fast to slow isoform switch. In general, we found that MHC isoforms were not altered by aging during mid-life. The HFS diet had the largest impact within the soleus muscle where the greatest slow to fast isoform shifts were observed in both mRNA and protein indicators. As expected, long-term resveratrol treatment counteracted, or blunted, these diet-induced shifts within the soleus muscle. The plantaris muscle also demonstrated a fast-to-slow phenotypic response to resveratrol treatment. In conclusion, diet or resveratrol treatment impacts skeletal muscle phenotype in a muscle-specific manner and resveratrol supplementation may be one approach for promoting the fatigue-resistant MHC (type I) isoform especially if its expression is blunted as a result of a long-term high fat/sugar diet.

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“…In addition, it has been shown that RSV promotes smooth muscle relaxation in human and animal models as blood vessels (5)(6)(7)(8)(9), human and rat uterus (10)(11)(12), gallbladder (13) as well and urinary bladder (14). Moreover, K channels have been implicated directly or indirectly in the actions of RSV (5,6,13).…”

Section: Introductionmentioning

confidence: 99%

“…While most of the effects of RSV were examined on vascular smooth muscle, the data of effects of RSV on other types of smooth muscle are limited on the uterus, gallbladder and urinary bladder. The mechanism of action of RSV on these types of smooth muscles partly included K channels (11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

Rajković

Djokic

Gostimirović

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a phytoalexin present in a variety of plant species. Resveratrol has a wide spectrum of pharmacologic properties, and it exhibits versatile biological effects on different human and animal models. The studies have shown that potassium (K) channels can be potential targets in the mechanism of resveratrol action. K channels play a crucial role in maintaining membrane potential. Inhibition of K channels causes membrane depolarization and then contraction of smooth muscles, while the activation leads to membrane hyperpolarization and subsequently, relaxation. Five diverse types of K channels have been identified in smooth muscle cells in different tissue: ATP-sensitive K channels (K ATP ), voltage-dependent K channels (Kv), Ca 2+ -and voltagedependent K channels (BK Ca ), inward rectifier K channels (Kir), and tandem two-pore K channels (K 2P ). The expression and activity of K channels altered in many types of diseases. Aberrant function or expression of K channels can be underlying in pathologies such as cardiac arrhythmia, diabetes mellitus, hypertension, preterm birth, preeclampsia, and various types of cancer. Modulation of K channel activity by molecular approaches and selective drug development may be a novel treatment modality for these dysfunctions in the future. The plant-derived non-toxic polyphenols, such as resveratrol, can alter K channel activity and lead to the desired outcome. This review presents the basic properties, physiological, pathophysiological functions of K channels, and pharmacological roles of resveratrol on the major types of K channels that have been determined in smooth muscle cells.

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Resveratrol prevents bradykinin-induced contraction of rat urinary bladders by decreasing prostaglandin production and calcium influx

Cited by 11 publications

References 29 publications

5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT_2Areceptor in partial bladder outlet obstruction in rats

5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT_2Areceptor in partial bladder outlet obstruction in rats

Muscle-Specific Myosin Heavy Chain Shifts in Response to a Long-Term High Fat/High Sugar Diet and Resveratrol Treatment in Nonhuman Primates

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

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Resveratrol prevents bradykinin-induced contraction of rat urinary bladders by decreasing prostaglandin production and calcium influx

Cited by 11 publications

References 29 publications

5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2Areceptor in partial bladder outlet obstruction in rats

5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2Areceptor in partial bladder outlet obstruction in rats

Muscle-Specific Myosin Heavy Chain Shifts in Response to a Long-Term High Fat/High Sugar Diet and Resveratrol Treatment in Nonhuman Primates

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

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Product

Resources

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5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT_2Areceptor in partial bladder outlet obstruction in rats

5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT_2Areceptor in partial bladder outlet obstruction in rats