Resveratrol potently reduces prostaglandin E2production and free radical formation in lipopolysaccharide-activated primary rat microglia

Candelario‐Jalil, Eduardo; Oliveira, Antônio Carlos Pinheiro de; Gräf, Sybille; Bhatia, Harsharan S.; Hüll, Michael; Muñóz, Eduardo; Fiebich, Bernd L.

doi:10.1186/1742-2094-4-25

Cited by 196 publications

(139 citation statements)

References 80 publications

(85 reference statements)

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“…Resveratrol has been found to modulate neuroinflammation in both in vivo and in vitro models, specifically targeting activated micloglial cells [71]. Actually, resveratrol suppresses the activation of the NF-kB pathway in LPS-activated microglia by reducing the phosphorylation and consequent degradation of its inhibitor, IkB [72][73][74][75]. Our results demonstrate that microglial, but not astroglial reactivity, was significantly diminished with resveratrol administration compared to untreated SOD1 G93A mice.…”

Section: Discussionmentioning

confidence: 60%

Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice

et al. 2014

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Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that causes progressive paralysis and death due to degeneration of motoneurons in spinal cord, brainstem and motor cortex. Nowadays, there is no effective therapy and patients die 2-5 years after diagnosis. Resveratrol (trans-3,4′,5-trihydroxystilbene) is a natural polyphenol found in grapes, with promising neuroprotective effects since it induces expression and activation of several neuroprotective pathways involving Sirtuin1 and AMPK. The objective of this work was to assess the effect of resveratrol administration on SOD1 G93A ALS mice. We determined the onset of symptoms by rotarod test and evaluated upper and lower motoneuron function using electrophysiological tests.We assessed the survival of the animals and determined the number of spinal motoneurons. Finally, we further investigated resveratrol mechanism of action by means of western blot and immunohistochemical analysis. Resveratrol treatment from 8 weeks of age significantly delayed disease onset and preserved lower and upper motoneuron function in female and male animals. Moreover, resveratrol significantly extended SOD1 G93A mice lifespan and promoted survival of spinal motoneurons. Delayed resveratrol administration from 12 weeks of age also improved spinal motoneuron function preservation and survival. Further experiments revealed that resveratrol protective effects were associated with increased expression and activation of Sirtuin 1 and AMPK in the ventral spinal cord. Both mediators promoted normalization of the autophagic flux and, more importantly, increased mitochondrial biogenesis in the SOD1 G93A spinal cord. Taken together, our findings suggest that resveratrol may represent a promising therapy for ALS.

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Section: Discussionmentioning

confidence: 60%

Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice

et al. 2014

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“…Resveratrol was reported to reduce the production of prostaglandin E2 (PGE2) and the formation of ROS in lipopolysaccharide (LPS)-activated microglial cells [53,54]. Moreover, resveratrol was reported to suppress the activity of T-and B-cells, and macrophages [55].…”

Section: Other Health Benefits Of Resveratrolmentioning

confidence: 99%

Erratum to: Resveratrol and red wine, healthy heart and longevity

2011

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Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.

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“…Resveratrol was reported to reduce the production of prostaglandin E2 (PGE2) and the formation of ROS in lipopolysaccharide (LPS)-activated microglial cells (Candelario-Jalil et al 2007;Kim et al 2007). Moreover, resveratrol was reported to suppress the activity of Tand B-cells, and macrophages (Sharma et al 2007).…”

Section: Health Benefit Of Resveratrolmentioning

confidence: 99%