Resveratrol Oxidation in<i>Botrytis cinerea</i>Conidia

Adrian, Marielle; Rajaei, Homa; Jeandet, Philippe; Veneau, Jérôme; Bessis, R.

doi:10.1094/phyto.1998.88.5.472

Cited by 63 publications

(37 citation statements)

References 41 publications

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“…In presence of the diterpenoids, the appearance of cytological abnormalities was not observed (data not shown). This result was different to those obtained with resveratrol, a natural phytoalexin; since it has been reported that this compound produced curved germ tubes and cytological abnormalities in B. cinerea conidia 18 . It is important to emphasize that this is the first work in which the antifungal effect against the fungus B. cinerea of two epimers was compared.…”

Section: Antifungal Activity Of Diterpenoids On B Cinereacontrasting

confidence: 95%

Characterization of the Antifungal Activity Against Botrytis Cinerea of Sclareol and 13-Epi-Sclareol, Two Labdane-Type Diterpenoids

Mendoza

Sepúlveda

Melo

et al. 2015

J. Chil. Chem. Soc.

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The antifungal activity of Sclareol and 13-epi-Sclareol, two labdane-type diterpenoids, on mycelial growth of the phytopathogenic fungus Botrytis cinerea was evaluated. Diterpenoid fungitoxicity was assessed using the radial growth test method. Both diterpenoids inhibited the mycelial growth of B. cinerea in solid medium; however the inhibitory activity of Sclareol was slightly higher than 13-epi-Sclareol with IC 50 value of 237.6 µg/mL and 268.8 µg/mL, respectively. On the other hand, both labdane-type diterpenoids did not alter the plasmatic membrane integrity; however the oxygen consumption of B. cinerea germinating conidia was affected. The evidence suggests that action mechanism of these molecules would be related to the uncoupling of mitochondrial oxidative phosphorylation. Finally, biotransformation of Sclareol by B. cinerea was analysed and the main biotransformed metabolite was identified as 3β-hydroxysclareol.

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Section: Antifungal Activity Of Diterpenoids On B Cinereacontrasting

confidence: 95%

Characterization of the Antifungal Activity Against Botrytis Cinerea of Sclareol and 13-Epi-Sclareol, Two Labdane-Type Diterpenoids

Mendoza

Sepúlveda

Melo

et al. 2015

J. Chil. Chem. Soc.

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“…98 The effect of an attack with Botrytis cinerea as a biotic stress factor 99 infl uenced apparently higher content in the year 2001. Lesser content in the skins in comparison with the seeds could be caused by its metabolization 100 and by the fact that only free trans-resveratrol was determined. Higher levels of trans-resveratrol were found in blue varieties as compared with white ones, 11 because resveratrol is more sensitive to oxidation in white musts.…”

Section: Effect Of Grape/vine Varieties and Cultivarsmentioning

confidence: 99%

Major factors influencing antioxidant contents and antioxidant activity in grapes and wines

Lachman¹,

Sulc²

2009

IJWR

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Phenolic compounds in wines, especially in red wines, possess strong antioxidant activity, have the largest effect in decreasing atherosclerosis by both hypolipemic and antioxidant mechanisms. The long-term uptake of red wine has a positive impact on antioxidant activity (AA) of blood plasma in rats in vivo and increases AA by 15%-20% compared to a control group. In the article the effect of total phenolics (TP), total anthocyanins (TA), individual anthocyanins, procyanidins and phenolics contained in red grapes, musts, grape seeds and skins and wines on the AA is discussed. Signifi cant impact of varieties, viticultural regions and locations, climate conditions and vintage has been shown. Likewise, the ways and individual stages of the vinifi cation technology process, and storage conditions affect color, TP, TA, and AA and health aspects of produced wines. Resveratrol, another free radical scavenger mainly contained in the skins of grapes, inhibits the risk of cardiovascular diseases. Higher amounts of trans-resveratrol (RES) have been found in wines from cool and wet climate regions and lesser amounts are typical for warm and dry regions. Changes in the TP content and AA affected by grape variety, vineyard location and winemaking process in white and blue varieties from different vineyards of the Czech Republic were studied. Signifi cant differences in TP among varieties were found. Analysis of variance showed statistically high differences among red and white wines and growing locations. Wines differed signifi cantly in TP content and AA increased signifi cantly during the winemaking process. Statistically signifi cant differences in AA values were found among growing areas, wines and varieties. Signifi cant positive correlations between TP and AA were determined. Total antioxidant status (TAS) of white and red wines (white and blue vine varieties) determined by DPPH and ABTS assays revealed signifi cant differences in AA between white and red wines. Moreover, differences were ascertained between individual varieties of red wine. The results obtained supported the assumption that variety plays a considerable role in TAS; the blue vine varieties showed a much higher TAS. Analysis of variance in AA showed statistically high signifi cance between red and white wines. AA increased during the winemaking process, the highest increase was determined during fermentation and maturation stages of red wine.

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“…The ability of B. cinerea to infect grapevine has been associated with its capacity to degrade stilbene phytoalexins. Laccase-mediated oxidation of resveratrol by a number of enzymes has been described (Adrian et al, 1998). Resveratrol have been also recognized as phytoalexin produced by Arachis and Trifolium (Leguminosae) and, Broussonetia (Moraceae), Festuca, Saccharum (Gramineae) and Veratrum (Liliaceae) (reviewed in Grayer and Harborne, 1994).…”

Section: In Response To Infection For Some Fungi Such Asmentioning

confidence: 99%

Induced plant secondary metabolites for phytopatogenic fungi control: a review

Ribera

Zúñiga

2012

J. Soil Sci. Plant Nutr.

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Pathogenic fungi constitute one of the main infectious agents in plants, causing alterations during developmental stages including post-harvest. Phytopathogenic fungi are controlled by synthetic fungicides; however, the use of these is progressively restricted due to both, the harmful effects of pesticides on the environment and human health and the appearance of highly resistant fungal strains. Therefore, there is a great demand for novel natural fungicides. Higher plants are rich source of bioactive secondary metabolites of wide variety such as tannins, terpenoids, saponins, alkaloids, flavonoids, and other compounds, reported to have in vitro antifungal properties. Thus, secondary metabolites with antifungal activity represent an alternative for achieving a sustainable control of phytopathogenic fungi and to reduce the heavy reliance of synthetic pesticides used to control them. Plant antifungal metabolites may be preformed inhibitors that are present constitutively in healthy plants (phytoanticipins), or they may be synthesized de novo in response to pathogen attack or another stress conditions (phytoalexins). These molecules may be used directly or considered as a precursor for developing better fungicidal molecules. This review presents a selection of antifungal agents induced in plants during fungal attack that can be potentially used for phytopathogenic fungi control in crops.

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Resveratrol Oxidation inBotrytis cinereaConidia

Cited by 63 publications

References 41 publications

Characterization of the Antifungal Activity Against Botrytis Cinerea of Sclareol and 13-Epi-Sclareol, Two Labdane-Type Diterpenoids

Characterization of the Antifungal Activity Against Botrytis Cinerea of Sclareol and 13-Epi-Sclareol, Two Labdane-Type Diterpenoids

Major factors influencing antioxidant contents and antioxidant activity in grapes and wines

Induced plant secondary metabolites for phytopatogenic fungi control: a review

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