Resveratrol: Nanocarrier-Based Delivery Systems to Enhance its Therapeutic Potential

Abstract

Resveratrol (3,5,4′-trihydroxystilbene) is a polyphenolic compound existing in trees, peanuts and grapes and exhibits a broad spectrum of promising therapeutic activities, but it is unclear whether this entity targets the sites of action after oral administration. In vivo applicability of resveratrol has limited success so far, mainly due to its incompetent systemic delivery resulting from its low water solubility, poor bioavailability and short biological half-life. First-pass metabolism and presence of enterohepatic recirculation create doubt on the biological application of high doses typically used for in vitro trials. To augment bioavailability, absorption and uptake of resveratrol by cellular internalization, countless approaches have been implemented which involve the use of nanocarriers. Nanocarriers are a well-known delivery system used to reduce first-pass hepatic metabolism, overcome enterohepatic recirculation and accelerate the absorption of drugs via lymphatic pathways.

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

“…Nanotechnology-based resveratrol delivery systems, as means of increasing its bioavailability and consequently its therapeutic potential, are lately gaining strong research interest. Various biocompatible materials of different working range sizes that are non-toxic, easily digested and metabolized, are being developed as potential drug delivery systems in addition to conventional oil-in-water nanoemulsion systems such as pickering emulsions, microbubbles, liposomes and gold nanoparticles [ 84 , 85 ].…”

Green Solvents Combined with Bioactive Compounds as Delivery Systems: Present Status and Future Trends

“…The uses of bioactive compounds from natural and synthetic origins in the healthcare system are continuously rising, because of their biological properties (e.g., anti-inflammatory, antibacterial, antiaging, anticancerogenic, antiadipogenic), lower cost, and high safety margins . Prominent plant-derived compounds, namely, curcumin, rutin, quercetin, resveratrol, and others from synthetic origins (e.g., ibuprofen, ketoprofen) have been reported in delivery systems. − However, the translation of preclinical data into effective clinical progress is still a significant obstacle in this field. According to the literature, the bioactive compounds, mainly those from natural sources, have low water solubility or solubility in toxic organic compounds, which are the main reasons for their limited expansion in practical uses .…”

“…Also, it promotes their detoxification to avoid oxidative damage to the target cell DNA, reduce inflammation, and the proliferation of tumor cells . Despite these therapeutical effects, in vivo applicability of resveratrol in the delivery system has limited success, because of its poor bioavailability and low water solubility …”

“…58 Despite these therapeutical effects, in vivo applicability of resveratrol in the delivery system has limited success, because of its poor bioavailability and low water solubility. 30 Paclitaxel (PTX), which is a chemotherapeutical diterpenoid drug, was initially isolated from the Western Yew bark (Taxus brevifolia), but it has also been later found in endophytic fungi. 61,62 PTX displays potent anticancer action against different cancer types, e.g., advanced nonsmall-cell lung carcinoma, breast carcinoma, and ovarian carcinoma.…”

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to Covid-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

“…Nanotechnology-based resveratrol delivery systems, as means of increasing its bioavailability and consequently its therapeutic potential, are lately gaining strong research interest. Various biocompatible materials of different working range sizes that are nontoxic, easily digested and metabolized, are being developed as potential drug delivery systems in addition to conventional oil-in-water nanoemulsion systems such as pickering emulsions, microbubbles, liposomes and gold nanoparticles [84,85].…”