2020
DOI: 10.2217/nnm-2020-0289
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Resveratrol: Nanocarrier-Based Delivery Systems to Enhance its Therapeutic Potential

Abstract: Resveratrol (3,5,4′-trihydroxystilbene) is a polyphenolic compound existing in trees, peanuts and grapes and exhibits a broad spectrum of promising therapeutic activities, but it is unclear whether this entity targets the sites of action after oral administration. In vivo applicability of resveratrol has limited success so far, mainly due to its incompetent systemic delivery resulting from its low water solubility, poor bioavailability and short biological half-life. First-pass metabolism and presence of enter… Show more

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Cited by 14 publications
(10 citation statements)
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“…Nanotechnology-based resveratrol delivery systems, as means of increasing its bioavailability and consequently its therapeutic potential, are lately gaining strong research interest. Various biocompatible materials of different working range sizes that are non-toxic, easily digested and metabolized, are being developed as potential drug delivery systems in addition to conventional oil-in-water nanoemulsion systems such as pickering emulsions, microbubbles, liposomes and gold nanoparticles [ 84 , 85 ].…”
Section: Bioavailability Of Resveratrolmentioning
confidence: 99%
“…Nanotechnology-based resveratrol delivery systems, as means of increasing its bioavailability and consequently its therapeutic potential, are lately gaining strong research interest. Various biocompatible materials of different working range sizes that are non-toxic, easily digested and metabolized, are being developed as potential drug delivery systems in addition to conventional oil-in-water nanoemulsion systems such as pickering emulsions, microbubbles, liposomes and gold nanoparticles [ 84 , 85 ].…”
Section: Bioavailability Of Resveratrolmentioning
confidence: 99%
“…The uses of bioactive compounds from natural and synthetic origins in the healthcare system are continuously rising, because of their biological properties (e.g., anti-inflammatory, antibacterial, antiaging, anticancerogenic, antiadipogenic), lower cost, and high safety margins . Prominent plant-derived compounds, namely, curcumin, rutin, quercetin, resveratrol, and others from synthetic origins (e.g., ibuprofen, ketoprofen) have been reported in delivery systems. However, the translation of preclinical data into effective clinical progress is still a significant obstacle in this field. According to the literature, the bioactive compounds, mainly those from natural sources, have low water solubility or solubility in toxic organic compounds, which are the main reasons for their limited expansion in practical uses .…”
Section: Bioactive Compoundsmentioning
confidence: 99%
“…Also, it promotes their detoxification to avoid oxidative damage to the target cell DNA, reduce inflammation, and the proliferation of tumor cells . Despite these therapeutical effects, in vivo applicability of resveratrol in the delivery system has limited success, because of its poor bioavailability and low water solubility …”
Section: Bioactive Compoundsmentioning
confidence: 99%
See 1 more Smart Citation
“…Nanotechnology-based resveratrol delivery systems, as means of increasing its bioavailability and consequently its therapeutic potential, are lately gaining strong research interest. Various biocompatible materials of different working range sizes that are nontoxic, easily digested and metabolized, are being developed as potential drug delivery systems in addition to conventional oil-in-water nanoemulsion systems such as pickering emulsions, microbubbles, liposomes and gold nanoparticles [84,85].…”
Section: Application Of Nanomaterials In Resveratrol Deliverymentioning
confidence: 99%