Resveratrol lowers synovial hyperplasia, inflammatory markers and oxidative damage in an acute antigen-induced arthritis model

Riveiro-Naveira, Romina R.; Valcarcel‐Ares, Marta Noa; Almonte-Becerril, Maylin; Vaamonde‐García, Carlos; Loureiro, Jesús; Hermida-Carballo, L.; Lopez-Pelaez, Eduardo; Blanco, Francisco J.; López-Armada, M.J.

doi:10.1093/rheumatology/kew255

Cited by 47 publications

(42 citation statements)

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“…Previous studies have shown that resveratrol has several anti‐inflammatory effects . In the CIA model, we found that resveratrol inhibited Src tyrosine kinase, STAT3, and Wnt signaling pathways, resveratrol‐ameliorated inflammatory arthritis.…”

Section: Discussionmentioning

confidence: 54%

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Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model

et al. 2018

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Resveratrol, a phytochemical, acts several cellular signaling pathways and has anti‐inflammatory potentials. The purpose of this study is to research the therapeutic effect of resveratrol in collagen‐induced arthritis (CIA) model in rats and whether resveratrol affects the activities of signaling pathways those are potent pathogenic actors of rheumatoid arthritis. Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund's adjuvant in Wistar albino rats. One day after the onset of arthritis (day 14), resveratrol (20 mg/kg/day) was given via oral gavage, until day 29. The paws of the rats were obtained for further analysis. Tissue Wnt5a, mitogen‐activated protein kinase (MAPK), Src tyrosine kinase and signal transducer, and activator of transcription‐3 (STAT3) mRNA expressions were determined by real‐time polymerase chain reaction. Resveratrol ameliorated the clinical and histopathological (perisynovial inflammation and cartilage‐bone destruction) findings of inflammatory arthritis. The tissue mRNA expressions of Wnt5a, MAPK3, Src kinase, and STAT3 were increased in the sham group compared to the control group. Resveratrol supplement decreased their expressions. The present study shows that Src kinase, STAT3, and Wnt signaling pathway are active in the CIA model. Resveratrol inhibits these signaling pathways and ameliorates inflammatory arthritis. © 2018 BioFactors, 45(1):69–74, 2019

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Section: Discussionmentioning

confidence: 54%

“…Resveratrol has been shown to reduce the expression of MMP and RANKL from RA‐FLSs . Moreover, anti‐arthritic potentials have been shown in in vivo settings (various experimental arthritis models) . Riveiro‐Naveira et al have reported that resveratrol reduces the severity of arthritis and joint swelling in the CIA model.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model

et al. 2018

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“…The adiponectin plays an anti-inflammatory role in the pathophysiology of several chronic inflammatory diseases and it has been reported to inhibit LPS-induced NFkB nuclear translocation and to affect other LPS-triggered pathways. To promote the weight control in eRA could be to prevent the oral infection REFERENCE: [1] Background: Previously, we have demonstrated that dietary supplementation with resveratrol (RSV) lowers synovial hyperplasia, chemokines and oxidative damage in an acute antigen-induced arthritis (AIA) model developed in rats, and that autophagic cell death and limiting angiogenic response were involved 1 . Objectives: Here, we investigated the autophagic flux induced by RSV and its relation with serum interleukin (IL)À1b levels, since autophagy could regulate IL-1b via inflammasome.…”

Section: Discussionmentioning

confidence: 99%

AB0120 Adiponectin could be a mediator of the presence of p gingivalis in patients with early rheumatoid arthritis

Chaparro

Bello-Gualtero

Valle-Oñate

et al. 2018

Rheumatoid Arthritis – Etiology, Pathogenesis and Animal Models

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BackgroundRheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterised by joint destruction, deformity, lower functional status and decrease in life expectancy. The Porphyromonas gingivalis (P. gingivalis) has been reported to be significantly associated with RA. The adipokines are suggested to be a common link between periodontitis and RAObjectivesTo determine the association between serum adipokines levels and presence of P gingivalis in patients with early rheumatoid arthritis (eRA) compared to healthy individualsMethodsA cross sectional study was conducted. Patients with the diagnosis of (eRA) according to the ACR/EULAR 2010 criteria were studied in Bogota-Colombia. A complete medical history related to RA was obtained. Adiponectin levels measured by Luminex technology (MILLIPLEXMAP ), IL6 by chemiluminescence (Immulite 1000, Siemens) and leptin quantification by ELISA (Diasource, ), high-sensitivity CRP (hs-CRP) (Immulite 1000, Siemmens) and ESR (Test 1 THL Ali FAX), and the detection of periodontopathic bacteria was carried out by qPCR from subgingival plaque samples. Cancer, autoimmune disease, infection, antibiotic use, diabetes, orthodontics treatment were exclusion criteria. An association analysis was made to evaluate the relationship between adipokines levels and periodontal, rheumatologic conditions using X2 test, Mann Whitney test and logistic regression model was performed to confirm this associations. All the results were performed with a level of significance of 95%ResultsA total of 51 patients with eRA and 51 healthy individuals were matched by age and gender. The mean age in RA patients was 48,54±10,93 years, 80,39% were female, between RA patients, 17.64% were in high activity and 27.45% in remission by DAS 28-ESR. 45.1% had APCA>20 UE. 37.25% were overweight and 13.72% were obese. 82.35% of patients had treatment, of which 80.39% received treatment with conventional disease modifying therapy, being methotrexate the most frequent one in 86.8%. In turn, 64.7% and 51% had high leptin and adiponectin levels respectively. An association of high adiponectin levels was found with Body Mass Index-BMI <25 (p=0.017). The presence of P gingivalis in RA patients was 78.4% and in healthy individuals was 45,09% p=0001. The adiponectin levels>47755 pg/ml were found associated with the absence of P gingivalis (OR=0.078 95% CI 0.01–0.62) adjusted an ever smoking history of cigarette smoking, Body Mass Index>30 and high level of leptin and IL6.ConclusionsThe adiponectin plays an anti-inflammatory role in the pathophysiology of several chronic inflammatory diseases and it has been reported to inhibit LPS-induced NFκB nuclear translocation and to affect other LPS-triggered pathways. To promote the weight control in eRA could be to prevent the oral infectionReference[1] Le Sage F, et al. Mol Cell Endocrinol2017;446:102–110.Disclosure of InterestNone declared

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“…In rabbit arthritis, intra-articular injection of RES dramatically reduced cartilage destruction [250]. On the other hand, in various models of experimental arthritis oral administration of RES reduced severity of disease, dampening release of proinflammatory cytokines, even including IL-17 [108,251,252].…”

Section: Allergy and Autoimmune Diseasesmentioning

confidence: 99%

Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies

Magrone

Russo

et al. 2019

Antioxidants

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In this review, special emphasis will be placed on red grape polyphenols for their antioxidant and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways responsible for activation of oxidative systems and expression and release of proinflammatory cytokines and chemokines will be discussed. Furthermore, regulation of immune cells by polyphenols will be illustrated with special reference to the activation of T regulatory cells which support a tolerogenic pathway at intestinal level. Additionally, the effects of red grape polyphenols will be analyzed in obesity, as a low-grade systemic inflammation. Also, possible modifications of inflammatory bowel disease biomarkers and clinical course have been studied upon polyphenol administration, either in animal models or in clinical trials. Moreover, the ability of polyphenols to cross the blood–brain barrier has been exploited to investigate their neuroprotective properties. In cancer, polyphenols seem to exert several beneficial effects, even if conflicting data are reported about their influence on T regulatory cells. Finally, the effects of polyphenols have been evaluated in experimental models of allergy and autoimmune diseases. Conclusively, red grape polyphenols are endowed with a great antioxidant and anti-inflammatory potential but some issues, such as polyphenol bioavailability, activity of metabolites, and interaction with microbiota, deserve deeper studies.

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Resveratrol lowers synovial hyperplasia, inflammatory markers and oxidative damage in an acute antigen-induced arthritis model

Abstract: Dietary supplementation with RSV lowers the main pathological hallmarks of RA disease in an acute model of AIA. RSV may represent a promising strategy in controlling the severity of RA.

Cited by 47 publications

References 49 publications

Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model

Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model

AB0120 Adiponectin could be a mediator of the presence of p gingivalis in patients with early rheumatoid arthritis

Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies

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