Resveratrol inhibits the phosphatidylinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in the human chronic myeloid leukemia K562 cell line

Sui, Tao; Ma, Li; Bai, Xue; Li, Qing; Xing, Xu

doi:10.3892/ol.2014.2014

Cited by 31 publications

(20 citation statements)

References 42 publications

(34 reference statements)

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“…In addition, Res was also reported to inhibit colon cancer cell proliferation through inhibition of PI3K and Wnt/β-catenin signaling pathways (12). Sui et al (13) showed that Res exhibited significant cytotoxic effects and induced apoptosis in K562 chronic myeloid leukemia cells via inhibiting the PI3K signaling pathway. The present study also found that Res had an inhibitory effect on the activity of the PI3K signaling pathway in chondrosarcoma cells, suggesting that inhibition of PI3K signaling may be a common molecular mechanism by which Res suppresses cancer cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

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Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways

Dai

Lei

Xie

et al. 2015

Molecular Medicine Reports

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Abstract. Chondrosarcoma is one of the most common types of primary bone cancer that develops in cartilage cells. Resveratrol (Res), a natural polyphenol compound isolated from various fruits, has a suppressive effect on various human malignancies. It has been shown that Res inhibits matrix metalloproteinase (MMP)-induced differentiation in chondrosarcoma cells. However, the effects of Res on cell proliferation, apoptosis and invasion of chondrosarcoma cells, as well as the underlying mechanisms, remain largely unknown. To the best of our knowledge, the present study showed for the first time that Res inhibited proliferation and induced apoptosis in chondrosarcoma cells in a dose-dependent manner. Furthermore, it was shown that Res also suppressed chondrosarcoma cell invasion in a dose-dependent manner, probably via the inhibition of MMP2 and MMP9 protein expression. Molecular mechanism investigations revealed that Res could inhibit the activity of phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase signaling pathways, which has been demonstrated to be important in the regulation of proliferation, apoptosis and invasion in various cancer cell types. In conclusion, this study suggests that Res may serve as a promising agent for the treatment of chondrosarcoma.

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Section: Discussionmentioning

confidence: 99%

“…Res has been demonstrated to suppress proliferation but induce apoptosis in multiple types of cancer (7,13). However, the effects of Res on chondrosarcoma cell proliferation and apoptosis remain unknown.…”

Section: Discussionmentioning

confidence: 99%

Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways

Dai

Lei

Xie

et al. 2015

Molecular Medicine Reports

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“…A possible explanation for the involvement of the PI3K pathway in the activation observed in the α‐MEM + is the presence of insulin in the medium, which acts primarily by activating this pathway (Khorami, Movahedi, Huzwah, & Sokhini, ). In regard to resveratrol, it exerts an anticancer effect by causing apoptosis in a range of cell lines through different mechanisms, including downregulation of the PI3K/AKT pathway (Chen et al, ; Sui et al, ). Interestingly, follicular activation observed in 2 µM resveratrol after PI3K inhibition was similar to that found in the control medium (α‐MEM + ) without using the inhibitor LY294002.…”

Section: Discussionmentioning

confidence: 99%

“…Resveratrol is known to have differential effects based on physiological, pathological and pharmacological conditions in various biological systems (Banu, Stanley, Sivakumar, Arosh, & Burghardt, 2016). In cancer cells, resveratrol induced apoptotic cell death, and therefore is used as a chemotherapeutic agent through downregulation of the PI3K/AKT pathway (Chen, Ganapathy, Singh, Shankar, & Srivastava, 2010;Sui, Ma, Bai, Li, & Xu, 2014). In contrast, resveratrol also has beneficial effects in other cells such as oocytes and granulosa cells.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol promotes in vitro activation of ovine primordial follicles by reducing DNA damage and enhancing granulosa cell proliferation via phosphatidylinositol 3‐kinase pathway

Bezerra

Gouveia

Barberino

et al. 2018

Reprod Domestic Animals

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We aimed to study the effects of resveratrol on the morphology, DNA fragmentation, follicular activation and cell proliferation after in vitro culture of ovine ovarian tissue, and to verify if PI3K pathway is involved in resveratrol action in the sheep ovary. Ovaries were collected and divided into fragments. One fragment was fixed for histology (fresh control). The remaining fragments were cultured for 7 days in control medium (α-MEM ) alone or with resveratrol (2, 10 or 30 µM). After culture, ovarian tissue was destined to morphological analysis. TUNEL and proliferating cell nuclear antigen (PCNA) analyses were performed in the fresh control, α-MEM and 2 µM resveratrol. Inhibition of PI3K activity was performed through pre-treatment with LY294002. The percentage of normal follicles was similar between α-MEM and 2 µM resveratrol, and higher than those in other resveratrol treatments. An increase in follicular activation was observed in all treatments compared to fresh control. DNA fragmentation decreased in tissues cultured in 2 µM resveratrol compared to α-MEM . Moreover, PCNA-positive cells were higher in 2 µM resveratrol than in α-MEM . LY294002 inhibited follicular activation stimulated by α-MEM and 2 µM resveratrol. In conclusion, 2 µM resveratrol promotes primordial follicle activation compared to the fresh control by reducing DNA fragmentation and stimulating granulosa cell proliferation through activation of the PI3K pathway.

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“…The PI3K/Akt pathway is involved in the regulation of a number of cellular processes including cell death and survival, cell proliferation, protein synthesis and cell metabolism (23,24). Accumulating evidence has indicated that activation of the PI3K/Akt pathway may confer acquired resistance to chemotherapeutic drugs with different mechanisms of actions: ADR, mitoxantrone, 5-fluorourocil, etoposide, camptothecin, etc (20,21).…”

Section: Discussionmentioning

confidence: 99%

Pristimerin overcomes adriamycin resistance in breast cancer cells through suppressing Akt signaling

Xie

Liang

et al. 2016

Oncology Letters

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Abstract. Breast cancer remains a major public health problem worldwide. Chemotherapy serves an important role in the treatment of breast cancer. However, resistance to chemotherapeutic agents, in particular, multi-drug resistance (MDR), is a major cause of treatment failure in cancer. Agents that can either enhance the effects of chemotherapeutics or overcome chemoresistance are urgently needed for the treatment of breast cancer. Pristimerin, a quinonemethide triterpenoid compound isolated from Celastraceae and Hippocrateaceae, has been shown to possess antitumor, anti-inflammatory, antioxidant and insecticidal properties. The aim of the present study was to investigate whether pristimerin can override chemoresistance in MCF-7/adriamycin (ADR)-resistant human breast cancer cells. The results demonstrated that pristimerin indeed displayed potent cytocidal effect on multidrug-resistant MCF-7/ADR breast cancer cells, and that these effects occurred through the suppression of Akt signaling, which in turn led to the downregulation of antiapoptotic effectors and increased apoptosis. These findings indicate that use of pristimerin may represent a potentially promising approach for the treatment of ADR-resistant breast cancer.

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Resveratrol inhibits the phosphatidylinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in the human chronic myeloid leukemia K562 cell line

Cited by 31 publications

References 42 publications

Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways

Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways

Resveratrol promotes in vitro activation of ovine primordial follicles by reducing DNA damage and enhancing granulosa cell proliferation via phosphatidylinositol 3‐kinase pathway

Pristimerin overcomes adriamycin resistance in breast cancer cells through suppressing Akt signaling

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