Resveratrol inhibits angiotensin II-induced endothelin-1 gene expression and subsequent proliferation in rat aortic smooth muscle cells

Chao, Hung-Hsing; Juan, Shu Hui; Liu, Ju-Chi; Yang, Hung-Yu; Yang, Eric V.; Cheng, Tzu-Hurng; Shyu, Kou‐Gi

doi:10.1016/j.ejphar.2005.03.035

Cited by 42 publications

(25 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was reported that resveratrol inhibited Ang II-induced endothelin-1 expression and proliferation of VSMCs through a suppression of AP1 activity. 22 In this study, we showed that Ang II-induced activation of CREB and NF-kB, which is involved in IL-6 induction, was inhibited by resveratrol. It was already reported that resveratrol inhibited NF-kB activity.…”

Section: Discussionmentioning

confidence: 83%

Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis

et al. 2009

View full text Add to dashboard Cite

Recent studies have shown that resveratrol (3,5,4¢-trihydroxystilbene), a polyphenolic compound found in grapes and red wine, has various beneficial effects on cardiovascular diseases and prolongs the life span of mice fed a high-fat diet. We hypothesized that resveratrol may attenuate vascular inflammatory response induced by angiotensin (Ang) II. We examined the effect of resveratrol on Ang II-induced interleukin (IL)-6 expression in vascular smooth muscle cells (VSMCs). Resveratrol significantly attenuated Ang II-induced IL-6 mRNA expression and IL-6 protein in the supernatant of VSMC in a dose-dependent manner. Resveratrol suppressed the IL-6 gene promoter activity. Resveratrol inhibited the Ang II-induced cAMP-response element-binding protein and nuclear factor-kappa B activity, which are critical for Ang II-induced IL-6 gene activation. An increase in the serum concentration of IL-6 induced by Ang II infusion was attenuated by an oral administration of resveratrol. Resveratrol also inhibited Ang II-induced hypertension and perivascular fibrosis of the heart. Although hydralazine reduced blood pressure level equal to resveratrol, it did not reduce the Ang II-induced IL-6 production and perivascular fibrosis. These data suggest that the inhibition of Ang II-induced vascular inflammation and high blood pressure by resveratrol may contribute, at least in part, to the anti-atherogenic effects of resveratrol.

show abstract

Section: Discussionmentioning

confidence: 83%

Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis

et al. 2009

View full text Add to dashboard Cite

show abstract

“…It is of interest to note that the effect of resveratrol was not directly connected with various ET receptor blockades in endothelial and myocardial cells, but resveratrol significantly inhibited strain-induced ET mRNA level, protein expression, and promoter activity (30). In additional studies, it was also proven that resveratrol inhibited angiotensin II-induced cell proliferation and ET expression (8), which is related to the phosphorylation of angiotensin IIinduced extracellular signal regulated kinase activity. We found that resveratrol significantly reduced ET expression in both OC and OϩG intake groups, and the reduction in ET expression was reflected in a direct attenuation of ET production in the resveratrol-treated hearts, in the absence or presence of glucose intake.…”

Section: Discussionmentioning

confidence: 99%

Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin

Lekli

Szabó

Juhász

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

103

View full text Add to dashboard Cite

Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin. Am J Physiol Heart Circ Physiol 294: H859-H866, 2008. First published December 7, 2007 doi:10.1152/ajpheart.01048.2007.-The resveratrol-induced cardiac protection was studied in Zucker obese rats. Rats were divided into five groups: group 1, lean control; group 2, obese control (OC); group 3, obese rats treated orally with 5 mg ⅐ kg Ϫ1 ⅐ day Ϫ1 of resveratrol (OR) for 2 wk; group 4, obese rats received 10% glucose solution ad libitum for 3 wk (OG); and group 5, obese rats received 10% glucose for 3 wk and resveratrol (OGR) during the 2nd and 3rd wk. Body weight, serum glucose, and insulin were measured, and then hearts were isolated and subjected to 30 min of ischemia followed by 120 min of reperfusion. Heart rate, coronary flow, aortic flow, developed pressure, the incidence of reperfusioninduced ventricular fibrillation, and infarct size were measured. Resveratrol reduced body weight and serum glucose in the OR compared with the OC values (414 Ϯ 10 g and 7.08 Ϯ 0.41 mmol/l, respectively, to 378 Ϯ 12 g and 6.11 Ϯ 0.44 mmol/l), but insulin levels were unchanged. The same results were obtained for the OG vs. OGR group. Resveratrol improved postischemic cardiac function in the presence or absence of glucose intake compared with the resveratrolfree group. The incidence of ventricular fibrillation and infarct size was reduced by 83 and 20% in the OR group, and 67 and 16% in the OGR group, compared with the OC and OG groups, respectively. Resveratrol increased GLUT-4 expression and reduced endothelin expression and cardiac apoptosis in ischemic-reperfused hearts in the presence or absence of glucose intake. Thus the protective effect of resveratrol could be related to its direct effects on the heart. heart; ischemia-reperfusion; diabetes; rat IN THE PAST THREE DECADES, an explosive increase in the number of people diagnosed with diabetes was seen worldwide (7, 48).

show abstract

“…Resveratrol exerts its anti-hypertrophic effects via several mechanisms including decrease of blood pressure, activation of the antihypertrophic signaling path of AMPK, and inhibition of the prohypertrophic path of Akt [7,8]. Studies indicated that resveratrol inhibits Ang II-induced cell proliferation, endothelin-1 expression, and ERK phosphorylation in vascular smooth muscle cells [9]. There is some evidence that resveratrol shows potential cardioprotective effects via Sirtuin-1 (SIRT1) activation [10].…”

Section: Introductionmentioning

confidence: 97%

The effect of resveratrol on angiotensin II levels and the rate of transcription of its receptors in the rat cardiac hypertrophy model

et al. 2016

View full text Add to dashboard Cite

This study investigated the effect of resveratrol on serum and cardiac levels of angiotensin II and transcription of its main receptors following pressure overload induced-hypertrophy. Rats were divided into untreated (Hyp) and resveratrol treated hypertrophied groups (H + R). Intact animals served as the control (Ctl). Cardiac hypertrophy was induced by abdominal aortic banding. Blood pressure (BP) was recorded via left carotid artery cannula. Fibrosis was confirmed by Masson trichrome staining. Angiotensin II level was measured using an ELIZA test. Gene expression was assessed by a real time PCR (RT-PCR) technique. We observed that in the H + R group BP and heart weight/body weight were decreased significantly (p < 0.001, p < 0.05, respectively vs Hyp). The cardiac levels of angiotensin II and AT1a mRNA were increased in the Hyp group (p < 0.01 vs Ctl). In the H + R group the AT1a mRNA level was decreased significantly (p < 0.05 vs Hyp). It could be concluded that resveratrol protects the heart against hypertrophy progression in part by affecting cardiac AT1a transcription.

show abstract

Resveratrol inhibits angiotensin II-induced endothelin-1 gene expression and subsequent proliferation in rat aortic smooth muscle cells

Cited by 42 publications

References 46 publications

Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis

Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis

Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin

The effect of resveratrol on angiotensin II levels and the rate of transcription of its receptors in the rat cardiac hypertrophy model

Contact Info

Product

Resources

About