This study investigated the effect of resveratrol on serum and cardiac levels of angiotensin II and transcription of its main receptors following pressure overload induced-hypertrophy. Rats were divided into untreated (Hyp) and resveratrol treated hypertrophied groups (H + R). Intact animals served as the control (Ctl). Cardiac hypertrophy was induced by abdominal aortic banding. Blood pressure (BP) was recorded via left carotid artery cannula. Fibrosis was confirmed by Masson trichrome staining. Angiotensin II level was measured using an ELIZA test. Gene expression was assessed by a real time PCR (RT-PCR) technique. We observed that in the H + R group BP and heart weight/body weight were decreased significantly (p < 0.001, p < 0.05, respectively vs Hyp). The cardiac levels of angiotensin II and AT1a mRNA were increased in the Hyp group (p < 0.01 vs Ctl). In the H + R group the AT1a mRNA level was decreased significantly (p < 0.05 vs Hyp). It could be concluded that resveratrol protects the heart against hypertrophy progression in part by affecting cardiac AT1a transcription.
Objective:
Hypertension is an important risk factor that causes many deaths in the
world every year. Researchers continue to undertake studies to find an effective drug for reducing
blood pressure. One of the phytochemicals that recently attracted the attention of researchers is
resveratrol-polyphenol, found in grapes. The purpose of this systematic review is to investigate the
effect of resveratrol as a cardioprotective agent effective in reducing hypertension in patients with
hypertension.
Methods:
Studies and clinical articles from databases Scopus, Pubmed, Ovid and Cochrane have
been collected until September 2017; the keywords are Blood Pressure, Hypertension, Hypertensive,
Cardiovascular, and Resveratrol.
Results:
Data from five studies with a total of 229 hypertensive and pre-hypertensive patients
(men and women) showed that resveratrol plays an important role in reducing blood pressure.
Conclusion:
Resveratrol appears to have anti-hypertensive effects, depending on the dose and duration
of treatment. Researchers attribute one of the important blood pressure reducing mechanisms
of resveratrol to increasing levels of NO. Based on the results of this systematic review, it is
suggested that more clinical studies be conducted to find the appropriate dose and duration of
treatment.
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