Resveratrol induces mitochondrial respiration and apoptosis in SW620 colon cancer cells

Blanquer-Rosselló, Ma del Mar; Hernández-López, Reyniel; Roca, Pilar; Oliver, Jordi; Valle, Adamo

doi:10.1016/j.bbagen.2016.10.009

Cited by 79 publications

(44 citation statements)

References 39 publications

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“…Resveratrol is considered to be a promising anticancer drug for chemoprevention or therapy for colon cancer, targeting numerous cellular molecules, such as AKT serine/threonine kinase 1 (AKT1), AKT2 [19], and AKT/GSK-3β/Snail signaling pathway [20], and increasing ROS production [21]. In the current study, RSV at a dose of 6 µ g/implant significantly reduced the tumor weight of s.c. (subcutaneously)-implanted COLO205-luc in athymic mice.…”

Section: Discussionmentioning

confidence: 60%

Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models

et al. 2020

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Cancer is a multifactorial disorder that induces mortality worldwide, and the colorectal type is the third most common cancer globally. Resveratrol (RSV) is a natural compound with an effective anticancer effect, especially against colorectal cancer, and therefore numerous studies recommended its use in colorectal cancer prevention and treatment. The current study investigated the effect of either RSV or its nanoformulation (NP-RSV) on the growth and vascularity of xenograft and orthotopic mice models in colon cancer (COLO205-luc). Both RSV and NP-RSV induced significant reductions in tumor growth and the hemoglobin percentages of the tumor mass, but NP-RSV showed greater bioavailability and efficacy than RSV. Generally, we recommend using NP-RSV as a therapeutic to control colon cancer.

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Section: Discussionmentioning

confidence: 60%

Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models

et al. 2020

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“…Resveratrol, a SIRT1 agonist, has recently been acknowledged to activate a mitochondrial apoptotic pathway in human cervical cancer cell [33, 34]. SIRT1 is a NAd+ dependent deacetylation enzyme.…”

Section: Discussionmentioning

confidence: 99%

FOXO1, a Potential Therapeutic Target, Regulates Autophagic Flux, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Human Cholangiocarcinoma QBC939 Cells

Zhang

Lei

et al. 2018

Cell Physiol Biochem

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Background/Aims: Autophagy is an evolutionarily conserved catabolic mechanism to maintain energy homeostasis and to remove damaged cellular components, which plays an important role in the survival of various cells. Inhibiting autophagy is often applied as a new strategy to halt the growth of cancer cells. Methods: The effect of FOXO1 gene on cellular function and apoptosis and its underlying mechanisms were investigated in cultured QBC939 cells by the methylthiazoletetrazolium (MTT) assay, western blot, DCFDA mitochondrial membrane potential, and ATP content measurement. FOXO1 siRNA was applied to down-regulate FOXO1 expression in QBC939 cells. Results: Here we reported that FOXO1, acetylation of FOXO1 (Ac-FOXO1) and the following interaction between Ac-FOXO1 and Atg7 regulated the basal and serum starvation (SS)-induced autophagy as evidenced by light chain 3 (LC3) accumulation and p62 degration. Either treatment with FOXO1 siRNA or resveratrol, a sirt1 agonist, inhibited autophagic flux, resulting in oxidative stress, mitochondrial dysfunction (MtD) and apoptosis in QBC939 cells, which were attenuated by enhancing autophagy with rapamycin. On the contrary, inhibiting autophagic flux with 3-MA worsened all these effects in QBC939 cells. Conclusions: Taken together, our study for the first time identified FOXO1 as a potential therapeutic target to cure against human cholangiocarcinoma via regulation of autophagy, oxidative stress and MtD.

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“…Resveratrol (Res; 3,4',5-trihydroxystilbene; C14H12O3) widely exists in grapes, berries, peanuts and wine, and possesses multiple confirmed therapeutic properties such as antioxidant, anti-inflammatory, anti-apoptotic and anticancer properties (4)(5)(6)(7)(8)(9). Indeed, Res suppresses malignant cell growth and reduces the expression levels of cancer-related genes; in addition, it induces cell cycle arrest and apoptosis (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol promotes the sensitivity of small-cell lung cancer H446 cells to cisplatin by regulating intrinsic apoptosis

Shi

Wang

et al. 2018

Int J Oncol

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The aim of the present study was to evaluate the effects of resveratrol on small-cell lung cancer (SCLC) cell proliferation and apoptosis. The results demonstrated that resveratrol concentration- and time-dependently reduced H446 cell viability. In addition, cells treated with resveratrol displayed higher apoptotic rates, in association with mitochondrial depolarization, cytochrome c release from the mitochondrial compartment to the cytoplasm, apoptosis-inducing factor translocation from the mitochondrial compartment to the nucleus, and altered protein levels of Bcl-2, Bcl-xL and Bax. Furthermore, resveratrol promoted H446 cell inhibition by cisplatin, as reflected by reduced viability and increased apoptosis. These findings suggest that resveratrol exerts antitumor effects on SCLC H446 cells and promotes H446 cell killing by cisplatin via modulation of intrinsic apoptosis.

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Resveratrol induces mitochondrial respiration and apoptosis in SW620 colon cancer cells

Cited by 79 publications

References 39 publications

Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models

Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models

FOXO1, a Potential Therapeutic Target, Regulates Autophagic Flux, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Human Cholangiocarcinoma QBC939 Cells

Resveratrol promotes the sensitivity of small-cell lung cancer H446 cells to cisplatin by regulating intrinsic apoptosis

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