Resveratrol increases stem cell function in the treatment of damaged pancreas

Abstract

Pancreatic damage results in insufficient insulin secretion, leading to type 1 diabetes. Stem cell-based therapy has recently shown potential in the treatment of type 1 diabetes. Resveratrol supplementation has demonstrated a beneficial effect in treating diabetes. This study investigates if adipose-derived stem cells (ADSC), preconditioned with resveratrol, show better effects on experimental diabetic animals. Wistar rats were randomly divided into four groups including sham (normal rats), DM (diabetic rats induced by SZT injection), DM+ADSC (DM rats with receiving autologous ADSC transplantation) and DM+R-ADSC (DM rats receiving resveratrol preconditioned ADSC). The experimental results show that SZT induced pancreatic damage (DM group), including reduction of islet size, fibrosis pathway activation, survival signaling suppression, and apoptotic pathway expression, lead to serum glucose elevation. Autologous ADSC (DM+ADSC group) transplantation shows improvement in the above observations in DM rats.Furthermore, ADSC precondition with resveratrol (DM+R-ADSC group) reveals significant improvement in the above pathological observations over both DM and DM+ADSC groups. We found that ADSC precondition with resveratrol increases the survival marker p-Akt expression, leading to enhanced ADSC viability. This

RETRACTED: Resveratrol Preincubation Enhances the Therapeutic Efficacy of hUC-MSCs by Improving Cell Migration and Modulating Neuroinflammation Mediated by MAPK Signaling in a Mouse Model of Alzheimer’s Disease

“…A previous experiment of ours showed that culturing with proper concentrations of resveratrol improved the proliferation and neural differentiation of hUC-MSCs in vitro (Wang et al, 2016). Other groups have also demonstrated that resveratrol pretreatment is safe, efficient, and low-cost, and pre-incubation of MSCs with resveratrol has yielded promising therapeutic effects on the treatment of acute kidney injury (Zhang et al, 2018), diabetic liver dysfunction, and pancreatic damage (Chen et al, 2019). Therefore, we speculate that resveratrol-primed MSCs are more resistant to chronic neuroinflammation in the brain of AD, and more efficient in treating AD.…”

Efficacy and Safety of Resveratrol in Type 1 Diabetes Patients: A Two-Month Preliminary Exploratory Trial

“…The major factors contributing to T1D-related hyperglycemia are reduced or no insulin secretion, decreased glucose utilization by the peripheral tissue, and increased glucose production. Resveratrol has been shown to improve all of the factors mentioned above in the setting of T1D, as reported by previous preclinical studies [18][19][20][21][22]. In this current study, we also observed that resveratrol treatment significantly reduced FBS and HbA1c in T1D patients.…”

Role of Hyperglycemia in the Senescence of Mesenchymal Stem Cells

“…Resveratrol, a small polyphenol, has emerged as a potential therapy due to its anticancer and anti-inflammatory properties. In diabetic animal models, AMSCs preconditioned with resveratrol showed increased stem cell function and better effects (Chen et al, 2019). One of the mechanisms is that resveratrol increases the expression of the survival marker p-Akt, resulting in enhanced AMSC viability (Cheng et al, 2016).…”