Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines

Fustier, Pierre; Corre, Ludovic Le; Chalabi, Nasséra; Vissac-Sabatier, Cécile; Communal, Y; Bignon, Y. J.; Bernard‐Gallon, Dominique

doi:10.1038/sj.bjc.6600983

Cited by 46 publications

(38 citation statements)

References 29 publications

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“…Ours is the first study to show that curcumin actually promotes DNA damage with subsequent effects on the BRCA1 DNA repair protein. Interestingly, these results are consistent with other studies showing that indole-3-carbinol (derived from cruciferous vegetables) and resveratrol (derived from red grapes) induce expression of BRCA1 30,31. Collectively, these studies point toward a trend of diet-derived polyphenol compounds in modulating the BRCA1 protein in cancer cells.…”

Section: Discussionsupporting

confidence: 91%

Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin

Rowe

Ozbay

O’Regan

et al. 2009

Breast Cancer�(Auckl)

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In the current study, we sought to examine the effects of curcumin in a specific type of breast cancer called triple negative breast cancer. These cancers lack expression of the estrogen and progesterone receptors and do not over-express HER2. Current treatment for triple negative breast cancers is limited to cytotoxic chemotherapy, and upon relapse, there are not any therapies currently available. We demonstrate here that the bioactive food compound curcumin induces DNA damage in triple negative breast cancer cells in association with phosphorylation, increased expression, and cytoplasmic retention of the BRCA1 protein. In addition, curcumin promotes apoptosis and prevents anchorage-independent growth and migration of triple negative breast cancer cells. Apoptosis and BRCA1 modulation were not observed in non-transformed mammary epithelial cells, suggesting curcumin may have limited non-specific toxicity. This study suggests that curcumin and potentially curcumin analogues should be tested further in the context of triple negative breast cancer. These results are novel, having never been previously reported, and suggest that curcumin could provide a novel, non-toxic therapy, which could lead to improved survival for patients with triple negative breast cancer. Curcumin should be studied further in this subset of breast cancer patients, for whom treatment options are severely limited.

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Section: Discussionsupporting

confidence: 91%

Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin

Rowe

Ozbay

O’Regan

et al. 2009

Breast Cancer�(Auckl)

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“…The expression of BRCA1 and BRCA2 mRNAs increased although no change in the expression of the proteins was found [55]. Germ-line mutations in the breast susceptibility genes BRCA1 and BRCA2 confer a high risk for developing breast and ovarian cancer [80,81].…”

Section: Other Chemoprevention Effects Of Res In Breast Cancermentioning

confidence: 97%

Resveratrol and breast cancer chemoprevention: Molecular mechanisms

Corre

Chalabi

Delort

et al. 2005

Mol. Nutr. Food Res.

143

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Despite years of intensive research, breast cancer remains a major cause of death among women. New strategies to combat breast cancer are being developed, one of the most exciting of which is the use of chemopreventive agents. Resveratrol (RES) is a polyphenolic compound found in plants that seems to have a wide spectrum of biological activity. RES has been shown to afford protection against several types of cancer. This review summarizes the chemopreventive effects of RES at the three major stages of breast carcinogenesis: initiation, promotion, and progression. It has anti-oxidant and anti-inflammatory properties, and may induce apoptosis as well as modulate cell cycle and estrogen receptor function in breast cancer cell lines. Although RES has shown remarkable promise as a potent chemopreventive agent in breast cancer, further studies are needed to etablish its usefulness.

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“…Resveratrol acts also as a phytoestrogen and it is an agonist of the ERα [83]. In breast tumor cell lines, resveratrol mimicked the effects of estrogen and induced BRCA-1 mRNA levels [84].…”

Section: Dietary Polyphenolsmentioning

confidence: 99%

Role of Dietary Xenobiotics-Gene Interactions in Carcinogenesis: Protective Effects of Nutritional Factors

Romagnolo¹,

Degner

Kemp

et al. 2006

CNF

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In this paper, we discuss how interactions between dietary xenobiotics and nutrients influence cancer risk by modulating overlapping biochemical pathways leading to repression of tumor suppressor genes, activation of tumor promoters, or both. Epidemiologic studies in humans suggested that diet is an important vehicle of exposure to various xenobiotics, including polycyclic aromatic hydrocarbons (PAHs), dioxins, and chlorinated hydrocarbons (CHs). The activation of the aromatic hydrocarbon receptor (AhR) pathway by PAHs and dioxins stimulates the expression of several genes including cytochrome P450s, which metabolize PAHs to highly mutagenic compounds that cause fixation of mutations in the p53 gene and repress the expression of the tumor suppressor gene, BRCA-1. Conversely, PAHs and dioxins have been shown to activate the expression of cyclooxygenase-2 (COX-2), whose protein product participates in the production of reactive PAH-metabolites and synthesis of proinflammatory prostaglandins (PGs). The carcinogenicity of CHs has been attributed to their ability to activate the expression of oncogenes including c-myc, and fatty acid activation of the peroxisome proliferator-activated receptor-α (PPARα). Dietary components that may protect against the activation of the AhR pathway include flavonoids, which comprise a large family of dietary phenolic phytochemicals found in fruits and vegetables. Nutrients such as dietary fatty acids may differentially influence the risk of cancer by inducing (linoleic and arachidonic acid) or repressing (conjugated linoleic acid (CLA); n-3PUFA) the expression of COX-2. Finally, we present original findings produced in our laboratory documenting the protective effects of natural (genestein) and synthetic (α-naphthoflavone) flavonoids against PAH-induced changes in gene expression.

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Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines

Cited by 46 publications

References 29 publications

Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin

Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin

Resveratrol and breast cancer chemoprevention: Molecular mechanisms

Role of Dietary Xenobiotics-Gene Interactions in Carcinogenesis: Protective Effects of Nutritional Factors

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