Resveratrol and breast cancer chemoprevention: Molecular mechanisms

Corre, Ludovic Le; Chalabi, Nasséra; Delort, Laëtitia; Bignon, Yves‐Jean; Bernard‐Gallon, Dominique

doi:10.1002/mnfr.200400094

Cited by 143 publications

(92 citation statements)

References 88 publications

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“…60 Alternatively, polyphenols can inhibit ROS generating transcription factors closely linked to inflammation (e.g., NF-kB 24 ) and enzymes such as xanthine oxidase (XO) (curcumin 63 ), COX-2 (curcumin 64 ) or LOX (curcumin, silymarin, and resveratrol 65 ) that mediate inflammatory processes. 66 Polyphenols can also behave as detoxifying enzyme inducers, modulating gene expression including induction of phase II enzymes, such as glutathione S-transferases (GST) and quinone reductases (QR), which usually leads to protection of cells/tissues against exogenous and/or endogenous carcinogenic intermediates. 67 The antioxidant/electrophile response element (ARE/EpRE) found at the 5 0 -flanking region of these phase II genes may play important roles in mediating their induction by xenobiotics (including phenolic compounds 68 ).…”

Section: G Antioxidant and Anti-inflammatory Effectsmentioning

confidence: 99%

New insights on the anticancer properties of dietary polyphenols

et al. 2006

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Cancer, one of the major causes of death across the world, has shown to be a largely preventable disease, highly susceptible to modulation by dietary factors. Phenolic compounds, abundant in vegetables and fruits ubiquitous in diet, were described to play an important role as chemopreventive agents. Since conventional therapeutic and surgical approaches have not been able to control the incidence of most cancer types, the development of chemopreventive strategies is an urgent priority in public health. The current diet phenolic intake is often insufficient to protect from mutagens (either exogenous or endogenous), which leads to the need for dietary supplementation as an alternative approach. Research efforts are placing increasing emphasis on identifying the biological mechanisms and in particular the signal transduction pathways related to the chemopreventive activities of these compounds. These effects are believed to occur by the regulation of signaling pathways such as nuclear factor-kB (NF-kB), activator protein-1 (AP-1) or mitogen-activated protein kinases (MAPK). Dietary polyphenols can exert their effects on these pathways separately or sequentially and in addition the occurrence of crosstalk between these pathways cannot be overlooked. By modulating cell signaling pathways, polyphenols activate cell death signals and induce apoptosis in precancerous or malignant cells resulting in the inhibition of cancer development or progression. However, regulation of cell signaling pathways by dietary polyphenols can also lead to cell proliferation/survival or inflammatory responses due to increased expression of several genes. The present review summarizes the most recent advances providing new insights into the molecular mechanisms underlying the promising anticarcinogenic activity of dietary polyphenols. ß

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Section: G Antioxidant and Anti-inflammatory Effectsmentioning

confidence: 99%

New insights on the anticancer properties of dietary polyphenols

et al. 2006

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“…169 Other chemoprotective effects by resveratrol are mediated through activation of p53 via ERK and p38 kinase, inhibition of inflammatory mediators, and downregulation of Bcl-2 and NFB. 170,171 These properties of resveratrol directly oppose the purported cardioprotective benefits. For example, activation of the PI3-K signaling cascade and protection against apoptosis by 17␤-estradiol proves protective in cardiac myocytes.…”

Section: Resveratrolmentioning

confidence: 99%

The Effects of Biological Sex and Diet on the Development of Heart Failure

Konhilas

Leinwand

2007

Circulation

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“…The most highly investigated properties of phytoestrogens are their possible chemoprotective characteristics, especially those relevant to breast cancer [1,25,[27][28][29]. Epidemiological evidence suggests that diet and nutrition can influence cancer development, and Asian women report fewer post-menopausal symptoms and experience fewer breast cancers than women in Western countries [30][31][32]. More specifically, Asian women have a three-fold lower breast cancer risk than women in the United States, independent of body weight [33].…”

Section: Introductionmentioning

confidence: 99%

Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin

Mense

Chhabra

Bhat

2008

The Journal of Steroid Biochemistry and Molecular Biology

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Estrogen metabolism is suggested to play an important role in estrogen-induced breast carcinogenesis. Epidemiologic studies suggest that diets rich in phytoestrogens are associated with a reduced risk of breast cancer. Phytoestrogens are biologically-active plant compounds that structurally mimic 17β-estradiol (E 2 ). We hypothesize that phytoestrogens, may provide protection against breast carcinogenesis by altering the expression of estrogen-metabolizing enzymes cytochrome P450 1A1 (Cyp1A1) and 1B1 (Cyp1B1). Cyp1A1 and Cyp1B1 are responsible for the metabolism of E 2 to generate 2-hydroxyestradiol (2-OHE 2 ) and 4-hydroxyestradiol (4-OHE 2 ), respectively. Studies suggest that 2-OHE 2 and 2-methoxyestradiol may protect against breast carcinogenesis, while 4-OHE 2 is carcinogenic in rodent models. Thus, agents that increase the metabolism of E 2 by Cyp1A1 to produce 2-OHE 2 may have chemoprotective properties. The human immortalized non-neoplastic breast cell line MCF10F was treated with quercetin at 10 and 50 µM concentrations for time-points ranging from 3 to 48 hours. Total RNA and protein were isolated. Real-time PCR was used to measure the expression of Cyp1A1 and Cyp1B1 mRNA. Quercetin treatment produced differential regulation of Cyp1A1 and Cyp1B1 mRNA expression in a time-and dose-dependent manner. Treatment with 10 and 50 µM doses of quercetin produced 6-and 11-times greater inductions of Cyp1A1 mRNA over Cyp1B1 mRNA, respectively. Furthermore, quercetin dramatically increased Cyp1A1 protein levels and only slightly increased Cyp1B1 protein levels in MCF10F cells. Thus, our data suggest that phytoestrogens may provide protection against breast cancer by modulating expression of estrogen-metabolizing genes such that production of the highly carcinogenic estrogen metabolite 4-OHE 2 by Cyp1B1 is reduced and the production of the less genotoxic 2-OHE 2 by Cyp1A1 is increased.

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Resveratrol and breast cancer chemoprevention: Molecular mechanisms

Cited by 143 publications

References 88 publications

New insights on the anticancer properties of dietary polyphenols

New insights on the anticancer properties of dietary polyphenols

The Effects of Biological Sex and Diet on the Development of Heart Failure

Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin

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