Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins

Tomić, Jelena; McCaw, Lindsay; Li, Youjun; Hough, Margaret R.; Ben‐David, Yaacov; Moffat, Jason; Spaner, David

doi:10.1016/j.exphem.2013.04.004

Cited by 20 publications

(17 citation statements)

References 32 publications

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“…Furthermore, low levels of OGA correlate with tumor recurrence in hepatocellular carcinoma patients with liver transplants (12). Moreover, O-GlcNAc levels in blood and spleen are positively correlated with the burden of chronic lymphocytic leukemia (94). In addition, high expression of GFAT2 correlates with poor prognosis in breast cancer patients (95).…”

Section: Clinical Implications and Therapeutic Targetingmentioning

confidence: 99%

Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling

Vosseller

2014

Journal of Biological Chemistry

177

145

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O-Linked ␤-N-acetylglucosamine (O-GlcNAc) is a carbohydrate post-translational modification on hydroxyl groups of serine and/or threonine residues of cytosolic and nuclear proteins. Analogous to phosphorylation, O-GlcNAcylation plays crucial regulatory roles in cellular signaling. Recent work indicates that increased O-GlcNAcylation is a general feature of cancer and contributes to transformed phenotypes. In this minireview, we discuss how hyper-O-GlcNAcylation may be linked to various hallmarks of cancer, including cancer cell proliferation, survival, invasion, and metastasis; energy metabolism; and epigenetics. We also discuss potential therapeutic modulation of O-GlcNAc levels in cancer treatment.

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Section: Clinical Implications and Therapeutic Targetingmentioning

confidence: 99%

Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling

Vosseller

2014

Journal of Biological Chemistry

177

145

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“…In addition, they found OGT levels increased in high-grade bladder cancers compared to lower grade tumors. Moreover, Tomic et al showed that O-GlcNAc levels in blood and spleen reflected changes in tumor burden following treatment with resveratrol in mouse model of erythroleukemia 88 . Thus, urine or blood content of OGT and O-GlcNAc may be useful in diagnosis or as markers for therapeutic responses in some cancers.…”

Section: Introductionmentioning

confidence: 99%

O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling

Ferrer

Sodi

2016

Journal of Molecular Biology

227

192

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The Hexosamine Biosynthetic Pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine and acetyl-CoA. Increased flux through HBP leads to elevated post-translational addition of β-D-N-acetylglucosamine sugars to nuclear and cytoplasmic proteins. Increased total O-GlcNAcylation is emerging as a general characteristic of cancer cells and recent studies suggest that O-GlcNAcylation is a central communicator of nutritional status to control key signaling and metabolic pathways that regulate multiple cancer cell phenotypes. This review summarizes our current understanding of changes of O-GlcNAc cycling enzymes in cancer, the role of O-GlcNAcylation in tumorigenesis and the current challenges in targeting this pathway therapeutically.

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“…RSV treatment increased survival rate and reduced tumor burden with decreased spleen weight and high levels of O-GlcNAc (a marker of tumor progression) proteins in the spleen of both friend murine leukemia virus-or CB3 cell line-engrafted mouse erythroleukemias [115]. RSV could prolong the lifespan of mice engrafted with acute myeloblastic leukemia cells Kasumi-1, with the attenuation of signal transducer and activator of transcription 3 (STAT3) phosphorylation [116].…”

Section: Other Cancers In Recent Years (2009-2014)mentioning

confidence: 99%

“…High levels of post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc) moieties is a manifestation of tumor progression, and one feature of chronic lymphocytic leukemia cells [115]. RSV treatment increased survival rate and reduced tumor burden with decreased spleen weight and high levels of O-GlcNAc (a marker of tumor progression) proteins in the spleen of both friend murine leukemia virus-or CB3 cell line-engrafted mouse erythroleukemias [115].…”

Section: Other Cancers In Recent Years (2009-2014)mentioning

confidence: 99%

The pharmacology of resveratrol in animals and humans

Park

Pezzuto

2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

249

193

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In addition to thousands of research papers related to resveratrol (RSV), approximately 300 review articles have been published. Earlier research tended to focus on pharmacological activities of RSV related to cardiovascular systems, inflammation, and carcinogenesis/cancer development. More recently, the horizon has been broadened by exploring the potential effect of RSV on the aging process, diabetes, neurological dysfunction, etc. Herein, we primarily focus on the in vivo pharmacological effects of RSV reported over the past 5 years (2009-2014). In addition, recent clinical intervention studies performed with resveratrol are summarized. Some discrepancies exist between in vivo studies with animals and clinical studies, or between clinical studies, which are likely due to disparate doses of RSV, experimental settings, and subject variation. Nevertheless, many positive indications have been reported with mammals, so it is reasonable to advocate for the conduct of more definitive clinical studies. Since the safety profile is pristine, an added advantage is the use of RSV as a dietary supplement. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.

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Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins

Cited by 20 publications

References 32 publications

Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling

Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling

O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling

The pharmacology of resveratrol in animals and humans

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