O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling

Ferrer, Christina M.; Sodi, Valerie L.; Ma, Zhiyuan

doi:10.1016/j.jmb.2016.05.028

Cited by 229 publications

(202 citation statements)

References 95 publications

(217 reference statements)

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“…Furthermore, glutamine can contribute to the intracellular acetyl-CoA pool as well as to NAD/NADH levels, suggesting a potential role in regulating histone and protein acetylation levels and patterns. Moreover, it has also been shown that UDP-glucosamine (UDP-GlcNAc), used for N-acetylglucosamination (GlcNAcylation) of histones and proteins and can regulate gene expression [88], can be synthesized from glutamine and can also be modulated by it through hexosamine biosynthesis via mTORC2 [89, 90]. …”

Section: Figurementioning

confidence: 99%

Glutamine Metabolism in Cancer: Understanding the Heterogeneity

et al. 2017

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Reliance on glutamine has long been considered a hallmark of cancer cell metabolism. However, some recent studies have challenged this notion in vivo, prompting a need for further clarifications on the role of glutamine metabolism in cancer. We find that there is ample evidence of an essential role for glutamine in tumors and that a variety of factors, including tissue type, the underlying cancer genetics, the tumor microenvironment and other variables such as diet and host physiology collectively influence the role of glutamine in cancer. Thus the requirements for glutamine in cancer are overall highly heterogeneous. In this review, we discuss the implications both for basic science and for targeting glutamine metabolism in cancer therapy.

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Section: Figurementioning

confidence: 99%

Glutamine Metabolism in Cancer: Understanding the Heterogeneity

et al. 2017

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“…25,26 To date, one of the most remarkable functions for glycosylation is its role in cell adhesion and migration, specifically in cancer metastasis. [27][28][29][30][31] In addition, glycans have been documented for their role in extracellular matrix (ECM) turnover and remodeling in multiple diseases. [32][33][34] Hence, there is a great need for high-throughput technologies to phenotype clinical diseases using glycoanalytic approaches.…”

Section: Metabolism Glycosylationmentioning

confidence: 99%

Novel Methods in Pulmonary Hypertension Phenotyping in the Age of Precision Medicine (2015 Grover Conference Series)

et al. 2016

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Among pulmonary vascular diseases, pulmonary hypertension (PH) is the best studied and has been the focus of our work. The current classification of PH is based on a relatively simple combination of patient characteristics and hemodynamics. This leads to inherent limitations, including the inability to customize treatment and the lack of clarity from a more granular identification based on individual patient phenotypes. Accurate phenotyping of PH can be used in the clinic to select therapies and determine prognosis and in research to increase the homogeneity of study cohorts. Rapid advances in the mechanistic understanding of the disease, improved imaging methods, and innovative biomarkers now provide an opportunity to define novel PH phenotypes. We have recently shown that altered metabolism may affect nitric oxide levels and protein glycosylation, the peripheral circulation (which may provide insights into the response to therapy), and exhaled-breath analysis (which may be useful in disease evaluation). This review is based on a talk presented during the 2015 Grover Conference and highlights the relevant literature describing novel methods to phenotype pulmonary arterial hypertension patients by using approaches that involve the pulmonary and systemic (peripheral) vasculature. In particular, abnormalities in metabolism, the pulmonary and peripheral circulation, and exhaled breath in PH may help identify phenotypes that can be the basis for a precision-medicine approach to PH management. These approaches may also have a broader scope and may contribute to a better understanding of other diseases, such as asthma, diabetes, and cancer.

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“…Nearly every cancer type examined to date has elevated levels of O-GlcNAcylation. The review by Ferrer et al [18] describes current findings indicating that O-GlcNAcylation of nucleocytoplasmic proteins is a central sensor and integrator of nutritional status to control important signaling pathways and processes that regulate cancer phenotypes. They summarize how O-GlcNAcylation cycling enzymes change in cancer cells and the various mechanisms by which O-GlcNAc contributes to cancer phenotypes; they alsopoint out the challenges in targeting O-GlcNAcylation that do develop therapeutics.…”

Section: Myriad Roles Of Glycans In Biologymentioning

confidence: 99%

Myriad Roles of Glycans in Biology

Hart¹

2016

Journal of Molecular Biology

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O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling

Cited by 229 publications

References 95 publications

Glutamine Metabolism in Cancer: Understanding the Heterogeneity

Glutamine Metabolism in Cancer: Understanding the Heterogeneity

Novel Methods in Pulmonary Hypertension Phenotyping in the Age of Precision Medicine (2015 Grover Conference Series)

Myriad Roles of Glycans in Biology

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