Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

Chachay, Veronique S.; Macdonald, Graeme A.; Martin, Jennifer; Whitehead, Jonathan P.; O’Moore-Sullivan, Trisha; Lee, Paul; Franklin, Michael E.; Klein, Kerenaftali; Taylor, Paul J.; Ferguson, Maree; Coombes, Jeff S.; Thomas, Gethin; Cowin, Gary; Kirkpatrick, Carl M.; Prins, Johannes B.; Hickman, Ingrid J.

doi:10.1016/j.cgh.2014.02.024

Cited by 251 publications

(260 citation statements)

References 79 publications

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“…In contrast to these reports, RES supplementation had no beneficial metabolic effects on nonobese, postmenopausal females with normal glucose tolerance when given at a dose of 75 mg/day for 12 weeks (59). Also, in a report from Australia comparing groups given 3 g RES (n = 10) or placebo (n = 10) for 8 weeks, RES was not efficient on reducing insulin resistance, steatosis, or abdominal fat distribution (60). Instead, there was a tendency that RES increased hepatic stress.…”

Section: Res As a Therapeutically Effective Drug In Human Liver Diseasementioning

confidence: 63%

Resveratrol: Is It Really Good for Liver Health?

Weiskirchen¹,

Weiskirchen²

2017

Hepat Mon

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Context: Resveratrol is a natural occurring stilbene present in a limited number of dietary food products and beverages. It is assumed that resveratrol has health-promoting effects by lowering low-density lipoprotein (LDL) cholesterol, improving microcirculation, and inhibiting platelet aggregation. Altogether, these beneficial effects lower the risk of cardiovascular disease. The "French paradox" assumes that a diet with moderate consumption of red wine lowers the risk of cancer and cardiovascular disease. Based on its healthful activities, a large number of studies were performed during the last decades investigating potential biological effects of resveratrol on liver homeostasis and its potential application as a hepatoprotective drug. Objectives: The current study aimed at discussing the proposed therapeutic attributes of resveratrol on liver health and its postulated mode of activity. Evidence Acquisition: To conduct the current study, the PubMed full-text archive depository for articles presenting data on resveratrol in liver health and disease was searched. Results: Out of the 9268 published articles on resveratrol, a total of 742 articles focused on liver. Among them, 352 articles investigated potential therapeutic activities. Although some of the reported in vitro and in vivo benefits of resveratrol were highly encouraging, well-designed clinical studies were missing. Conclusions: Presently, it is still premature to advise nutritional supplementation of resveratrol to cure hepatic diseases. Moreover, uncritical recommendation to drink wine as a liver health-promoting beverage should be avoided.

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Section: Res As a Therapeutically Effective Drug In Human Liver Diseasementioning

confidence: 63%

Resveratrol: Is It Really Good for Liver Health?

Weiskirchen¹,

Weiskirchen²

2017

Hepat Mon

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“…Clinical trials evaluating the effects of Resveratrol supplementation on NAFLD characteristics are scarce. A recent study, administering Resveratrol vs placebo for eight weeks, not only failed to show any significantly improvements in any NAFLD features in the Resveratrol group, it also showed an increase in hepatic stress, based on increased liver enzyme levels [41] . A different trial however, did find a significant improvement in NAFLD characteristics after 12 wk of supplementation with 500 mg Resveratrol [42] .…”

Section: Antioxidants Agentsmentioning

confidence: 99%

Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease

Eslamparast¹,

Eghtesad²,

Poustchi³

et al. 2014

WJH

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“…Three were undertaken with 500 mg and 600 mg resveratrol daily for 12 weeks, or 3000 mg daily for 8 weeks respectively. [24][25][26] Other two studies were carried out using 150 mg polyphenols (1.43% of flavonoids, 2.5% anthocyanins and 1.7% phenolic acid) extract of Hibiscus sabdariffa L. or 1350 mg of bayberry juice, daily for 12 weeks and 4 weeks in overweight and in young adults with NAFLD, respectively. [27,28] Finally, one study utilized 250 mL of pomegranate juice or orange juice per day associated with hypocaloric diet over a period of 12 weeks.…”

Section: Polyphenols and Nafldmentioning

confidence: 99%

Polyphenols treatment in patients with nonalcoholic fatty liver disease

Abenavoli

Milić

Luzza

et al. 2017

Journal of Translational Internal Medicine

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Nonalcoholic fatty liver disease (NAFLD) affects 25−30% of the general population worldwide and this high prevalence is linked with lifestyle and dietetic changes, not only in Western countries, but also in the urban areas of developing countries. Several pharmacological approaches were proposed in the treatment of NAFLD, but the reported results are inconclusive. International guidelines recommended the reduction of dietary fat and fructose, in association with some physical activity. In this context, it was reported that the protective effects of traditional Mediterranean diet, related to the high concentration of antioxidant compounds, particularly of polyphenols. Polyphenols are a heterogeneous class of plant derived compounds, with some proven hepatoprotective effects. Our opinion is that the adherence to traditional Mediterranean diet characterized by the consumption of antioxidant-rich foods in general and of polyphenols in particular, can be considered as a potential new approach in the treatment of NAFLD.

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Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

Cited by 251 publications

References 79 publications

Resveratrol: Is It Really Good for Liver Health?

Resveratrol: Is It Really Good for Liver Health?

Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease

Polyphenols treatment in patients with nonalcoholic fatty liver disease

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