Resveratrol derivative excited postsynaptic potentiation specifically via PKCβ-NMDA receptor mediation

Tong, Jia; Gao, Jingjing; Liu, Qingzhen; He, Chenyang; Zhao, Xing; Qi, Yanfei; Yuan, Tiangang; Li, Pengyan; Niu, Ming; Wang, Dongyao; Zhang, Le; Li, Weiyong; Wang, Jiabo; Zhang, Zhongjian; Peng, Shiyong

doi:10.1016/j.phrs.2019.104618

Cited by 10 publications

(6 citation statements)

References 58 publications

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“…Li et al [ 131 ], did demonstrate that mice treated with RSV (40 mg/kg RSV via IP) showed increased LTP response via field excitatory postsynaptic potential (fEPSP) of the dentate gyrus hippocampal region that protected against LTP impairments of chronic cerebral hypoperfusion. Tong et al [ 136 ] showed similar results in mouse hippocampal brain slices (C57BL/6 mice) that RSV (100 µM) was able to facilitate an increase in LTP (via fEPSP) and that RSV could rescue impairments in LTP in the presence of

-synuclein. Tong et al confirmed the findings of Wang et al in which RSV seems to promote the increased synaptic expression of AMPARs.…”

Section: Alzheimer’s Diseasementioning

confidence: 85%

Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease

Yang

Bagit

MacPherson

2021

IJMS

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Alzheimer’s disease (AD) has traditionally been discussed as a disease where serious cognitive decline is a result of Aβ-plaque accumulation, tau tangle formation, and neurodegeneration. Recently, it has been shown that metabolic dysregulation observed with insulin resistance and type-2 diabetes actively contributes to the progression of AD. One of the pathologies linking metabolic disease to AD is the release of inflammatory cytokines that contribute to the development of brain neuroinflammation and mitochondrial dysfunction, ultimately resulting in amyloid-beta peptide production and accumulation. Improving these metabolic impairments has been shown to be effective at reducing AD progression and improving cognitive function. The polyphenol resveratrol (RSV) improves peripheral metabolic disorders and may provide similar benefits centrally in the brain. RSV reduces inflammatory cytokine release, improves mitochondrial energetic function, and improves Aβ-peptide clearance by activating SIRT1 and AMPK. RSV has also been linked to improved cognitive function; however, the mechanisms of action are less defined. However, there is evidence to suggest that chronic RSV-driven AMPK activation may be detrimental to synaptic function and growth, which would directly impact cognition. This review will discuss the benefits and adverse effects of RSV on the brain, highlighting the major signaling pathways and some of the gaps surrounding the use of RSV as a treatment for AD.

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-synuclein. Tong et al confirmed the findings of Wang et al in which RSV seems to promote the increased synaptic expression of AMPARs.…”

Section: Alzheimer’s Diseasementioning

confidence: 85%

Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease

Yang

Bagit

MacPherson

2021

IJMS

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“…Resveratrol is a natural antioxidant polyphenol that is rich in the roots of Reynoutria japonica Houtt., wine, and grapes (Meng et al, 2020). Resveratrol has received extensive attention in recent years owing to its wide range of biological properties, including anti-aging, anti-oxidation, anti-inflammatory, and anti-cancer activities (Wang et al, 2018;Tong et al, 2020;Yu et al, 2020). Growing evidence indicates that resveratrol has potential effects in stimulating ovarian function and retarding ovarian aging.…”

Section: Resveratrolmentioning

confidence: 99%

The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging

et al. 2021

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The ovarian system comprises vital organs in females and is of great significance for the maintenance of reproductive potential and endocrine stability. Although complex pathogenesis undoubtedly contributes to ovarian aging, increasing attention is being paid to the extensive influence of oxidative stress. However, the role of oxidative stress in ovarian aging is yet to be fully elucidated. Exploring oxidative stress-related processes might be a promising strategy against ovarian aging. In this review, compelling evidence is shown that oxidative stress plays a role in the etiology of ovarian aging and promotes the development of other ovarian aging-related etiologies, including telomere shortening, mitochondrial dysfunction, apoptosis, and inflammation. In addition, some natural antioxidants such as quercetin, resveratrol, and curcumin have a protective role in the ovaries through multiple mechanisms. These findings raise the prospect of oxidative stress modulator-natural antioxidants as therapeutic interventions for delaying ovarian aging.

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“…[97] Several Chinese medicines such as Polygoni Multiflori Radix, Epimedii Folium, and Rhei Radix et Rhizoma have been scientifically evaluated to understand their toxicity type and injury mechanisms. [98,99] The results showed that Polygoni Multiflori Radix could only cause liver injury in a few susceptible individuals but is safe for the vast majority of people. This finding alleviated public doubts and panic regarding its safety.…”

Section: Research Valuementioning

confidence: 99%

Top 10 academic progress on traditional Chinese medicine in 2022

2023

Sci Tradit Chin Med

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Background To implement the spirit of the 20th National Congress of the Communist Party of China and the Opinions on Promoting the Inheritance, Innovation, and Development of Traditional Chinese Medicine (TCM), regularly summarize the research results of TCM, present the academic progress on TCM dynamically, and fully leverage the academic leadership of academic groups, the China Association of Chinese Medicine organized the selection of the top 10 academic progress on TCM in 2022. The selection process adhered to 4 orientations, eliminated any biases, highlighted the solutions to clinical problems, answered scientific questions, and led the industry’s development. It reflected an exploratory and forward-looking approach, emphasizing innovation and breakthroughs. The selection focused on new laws, new discoveries, new methods, new products, and new theories in the field of basic research and applied basic research in TCM. Through a process of dynamic collection, preliminary examination, review, and final judgment, the top 10 academic progress of TCM in 2022 were determined.

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Resveratrol derivative excited postsynaptic potentiation specifically via PKCβ-NMDA receptor mediation

Cited by 10 publications

References 58 publications

Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease

Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease

The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging

Top 10 academic progress on traditional Chinese medicine in 2022

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