Resveratrol content of some wines obtained from dried Valpolicella grapes: Recioto and Amarone

Celotti, E.; Ferrarini, Roberto; Zironi, R.; Purcaro, Giorgia

doi:10.1016/0021-9673(95)00962-0

Cited by 129 publications

(88 citation statements)

References 6 publications

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“…The rats were distributed into four experimental groups: wine and exercise group (WEG), wine group (WG), exercise group (EG) and control group (CG). Red wine in doses of 3.715 ml/kg/day (commensurate with daily consumption considered moderate for a 70 kg human scaling down to an approximately 0.333 kg rat) 19,20 . These were given by intra-gastric gavage, for ten weeks, five times a week, early in the morning.…”

Section: Methods Samplementioning

confidence: 99%

Efeito do vinho tinto associado ao exercício físico no sistema cardiovascular de ratos espontaneamente hipertensos

Filho

Castro²,

Stahlschmidt³

2011

Arq. Bras. Cardiol.

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Background: Physical exercise (PE) is effective in the treatment and prevention of hypertension associated with improved lipid profile and cardiac contractile function. Regular and moderate consumption of alcoholic beverages such as red wine brings a cardiovascular protective effect. Beverage-derived polyphenols have antioxidant properties benefiting blood vessels. There is little evidence on the consumption of red wine associated with PE and the influences on the cardiovascular system.

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Section: Methods Samplementioning

confidence: 99%

Efeito do vinho tinto associado ao exercício físico no sistema cardiovascular de ratos espontaneamente hipertensos

Filho

Castro²,

Stahlschmidt³

2011

Arq. Bras. Cardiol.

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“…The phenolic compound resveratrol activates sirtuins and increases the life span in Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and the fish Nothobranchius furzeri, but its efficacy in mammals is uncertain (Evason et al 2005;Howitz et al 2003;Kang et al 2002;Valenzano et al 2006). Resveratrol is present in grapes and red wine at relatively high concentration (Celotti et al 1996).…”

Section: Acetylation Of Histonesmentioning

confidence: 99%

Nutrition, Histone Epigenetic Marks, and Disease

Zempleni

Liu

Xue

2013

Environmental Epigenomics in Health and Disease

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The dietary intake of essential nutrients and bioactive food compounds is a process that occurs on a daily basis for the entire life span. Therefore, your diet has a great potential to cause changes in the epigenome. Known histone modifications include acetylation, methylation, biotinylation, poly(ADP-ribosylation), ubiquitination, and sumoylation. Some of these modifications depend directly on dietary nutrients. For other modifications, bioactive dietary compounds may alter the activities of enzymes that establish or remove histone marks, thereby altering the epigenome. This chapter provides an overview of diet-dependent epigenomic marks in histones and their links with human health.

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“…24,25 Notably, resveratrol is present in the weed Polygonum cuspidatum and in the grape (Vitis vinifera), both being very important elements for human nutrition as basic food products in China-Japan and the Mediterranean area, respectively. Resveratrol is highly concentrated in red wine (5 mg/L in average, ranging from 0.5 to 10 ppm), 26 which is considered the principal source of this compound for humans. Resveratol has been repeatedly invoked to explain the so-called French Paradox, i.e., the lower incidence of cardiovascular diseases in the French population despite a diet very reach in saturated fats, 27 and to be related to all the subsequent epidemiological studies which correlated moderate consumption of red wine with reduced risk for a series of diseases.…”

Section: Resveratrolmentioning

confidence: 99%

Resveratrol and the Pharmacology of Aging: A New Vertebrate Model to Validate an Old Molecule

Valenzano

Cellerino²

2006

Cell Cycle

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The natural phytoalexin resveratrol, found in grapes and red wine, recently rose to public fame for its positive effects on longevity in yeasts, worms and flies. Resveratrol anti-cancer and anti-inflammatory in vitro action on mammalian cell cultures also suggest a possible positive effect on human health and life-expectancy. To study the effects of resveratrol on vertebrate aging is obviously a particularly relevant question. We have studied resveratrol effects in a very short-lived vertebrate: the annual fish Nothobranchius furzeri. Resveratrol treatment prolonged lifespan and delayed the onset of age-related dysfunctions in this fish. This result identifies resveratrol as the first molecule which consistently retards aging in organisms as diverse as yeast, worm, fly and fish, but it also reveals the potential of this short-lived fish as an animal model for pharmacological research. Moreover, being related to stickleback (Gasterosteus aculeatus) the "pufferfishes" Takifugu and Tetraodon, and even more closely related to medaka (Oryzias latipes), it can greatly beneficiate from the recent development of genomic resources for these fish models and in the future become a complete model system for the aging research community. PHARMACOLOGY OF AGINGThe identification of molecules which can prevent the occurrence of age-related pathologies is a remarkably important issue for contemporary medical research. However, any pharmacological research on aging needs to face the hurdle imposed by the lifespan of the available model organisms which prevents the possibility of large-scale drug discovery.All these difficulties notwithstanding, several small molecules were identified which increase lifespan of model organisms when administered with food. Some of these compounds, like ethoxyquin, 1 have toxic effects, and are able only to increase lifespan of short-lived mouse strains. Others, like deprenyl, 2,3 are psychoactive drugs and are classifies as control substance.One popular theory often invoked to explain the mechanisms of aging is the free radical theory of aging, 4 which identifies in the production of reactive oxygen species from the mitochondria the pivotal mechanism for aging initiation and progression. The importance of free radical produced by the mitochondria for vertebrate aging, is strongly suggested by the extension of lifespan and retardation of aging achieved by reducing oxidative stress through overexpression of human catalase in mice mitochondria, 5 and by the recent report that the p66shc adaptor protein gene, whose deletion causes significant life extension in mice, 6,7 can generate reactive oxygen species by a direct interaction with cytochrome c.This theory predicts that exogenously-supplied antioxidants will produce life extension. Several antioxidants such as Lipoic Acid, 8 butylated hydroxytoluene, 9 N-acetylcysteine, 10 sodium solenite, 11 sodium hypophosphite, 12 were all found, indeed, to increase lifespan in Drosophila, whereas life-extension was induced in nematodes by Ginko biloba ex...

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Resveratrol content of some wines obtained from dried Valpolicella grapes: Recioto and Amarone

Cited by 129 publications

References 6 publications

Efeito do vinho tinto associado ao exercício físico no sistema cardiovascular de ratos espontaneamente hipertensos

Efeito do vinho tinto associado ao exercício físico no sistema cardiovascular de ratos espontaneamente hipertensos

Nutrition, Histone Epigenetic Marks, and Disease

Resveratrol and the Pharmacology of Aging: A New Vertebrate Model to Validate an Old Molecule

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