Nutrition, Histone Epigenetic Marks, and Disease

Abstract

The dietary intake of essential nutrients and bioactive food compounds is a process that occurs on a daily basis for the entire life span. Therefore, your diet has a great potential to cause changes in the epigenome. Known histone modifications include acetylation, methylation, biotinylation, poly(ADP-ribosylation), ubiquitination, and sumoylation. Some of these modifications depend directly on dietary nutrients. For other modifications, bioactive dietary compounds may alter the activities of enzymes that establish or remove histone marks, thereby altering the epigenome. This chapter provides an overview of diet-dependent epigenomic marks in histones and their links with human health.

Low activity of LSD1 elicits a pro-inflammatory gene expression profile in riboflavin-deficient human T Lymphoma Jurkat cells

“…It is widely recognized that nutritional factors play a role in methylation events, albeit the majority of previous studies focused on methyl donors (Zempleni et al 2012). Importantly, in a recent publication, we expanded that point of view and demonstrated that FAD-dependent demethylation events, mediated by LSD1, cause an aberrant increase in the expression of albumin in human liver cells (Liu and Zempleni 2014).…”