Resveratrol-conjugated poly-ε-caprolactone facilitates in vitro mineralization and in vivo bone regeneration

Calcification in vitro of biomineralizated nanohydroxyapatite/superydrophilic vertically aligned multiwalled carbon nanotube scaffolds

“…Less significant increase of calcification can be noticed in nHAp/VAMWCNT-O 2 14D and nHAp/ VAMWCNT-O 2 21D. These results are complementary to those presented in literature 7,14,15 , which performed ALP test in CNTs and observed that HOB cells showed higher proliferation in samples of CNTs than in another biomaterial, which was similar to the result shown in Figures 2 and 3. …”

Surface functionalization of bioactive glasses with natural molecules of biological significance, part II: Grafting of polyphenols extracted from grape skin

“…Some researches indicated phenol functionalization of carbon nanotubes to improve their mechanical and dynamic properties [22]. It has been observed that the incorporation of resveratrol (stilbenes from grapes, peanuts and berries) with porous poly-ε-caprolactone (PCL) surface can improve the alkaline phosphatase (ALP) activity of rat bone marrow stromal cells and can enhance mineralization of the cell-scaffold composites in vitro [23].…”

“…In this way the functionalized biomaterial surface acts as localized carrier for the biological principle and this represents a challenging strategy to send specific signals to cells and tissues via in situ delivery. Many research papers deal with the surface grafting of proteins, enzymes and drugs [15,16,[19][20][21] on different kinds of biomaterials, although few are related to polyphenols and natural biomolecules [22,23].…”

ε-Caprolactone in Micro-Chambered Ceramic Beads - A New Carrier for Gentamicin

“…Biocompatibility was proven in all studies [44]. ε-Caprolactone is used for vascular tissue engineering [45], tissue culturing with chondroblasts [46], in in vitro and in vivo bone regeneration [47,48,49], peripheral nerve regeneration [50] and skin tissue engineering [51], as barrier membrane in periodontology [52] and, for many years, as root-filling material in dentistry [19,20,53,54]. Biocompatibility has been proven in all experimental and clinical studies [21].…”