Resveratrol benefits the lineage commitment of bone marrow mesenchymal stem cells into osteoblasts via miR‐320c by targeting Runx2

Zou, Jilong; Du, Jianyang; Tu, Hualei; Chen, Hongjun; Cong, Kai; Zhang, Bi; Sun, Jiamei

doi:10.1002/term.3176

Cited by 13 publications

(5 citation statements)

References 57 publications

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“…Other studies have reported that RSV induces osteoblastic differentiation in pathological and non-pathological conditions [ 47 , 48 , 49 ]. The treatment with RSV in multiple myeloma cells inhibits the growth of tumor cells and also acts on the microenvironment, inhibiting osteoclastogenesis and, thus, bone resorption and inducing osteoblastic differentiation [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

et al. 2022

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Osteosarcoma (OS) is the most common primary bone sarcoma affecting the life of pediatric patients. The clinical treatment faces numerous difficulties, including the adverse effects of chemotherapies, chemoresistance, and recurrences. In this study, the effects of resveratrol (RSV), a natural polyphenol, on OS cell lines were investigated to evaluate its action as an adjuvant therapy to the current chemotherapy regimens. RSV exhibited multiple tumor-suppressing activities on OS cell lines, inducing a series of critical events. We found (1) a cell growth inhibition due to an increase in cell distress, which was, in part, due to the involvement of the AKT and caspase-3 pathways, (2) an increase in cellular differentiation due to major gene expression levels of the osteoblastic differentiation genes, (3) an inhibition of IL-6 secretion due to an epigenetic effect on the IL-6 promoter, and (4) an inhibition of OS cells migration related to the decrease in IL-8 secretion levels due to an epigenetic effect on its promoter. Finally, the cotreatment of RSV with doxorubicin and cisplatin increased their cytotoxic effect on OS cells. Although further investigations are mandatory, it seems RSV might be a promising therapeutic adjuvant agent for OS cell treatment, exerting an antitumor effect when combined with chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

et al. 2022

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“…Over-expression miR-320c suppressed osteoblastic differentiation of BMSCs by targeting Runx2 in RSVL, while down-regulation of miR-320c accelerated osteoblastic differentiation of BMSCs. In conclusion, miR-320c can be used as a new target to regulate the biological function of BMSCs with RSVL (25).…”

Section: Mirna Regulates Osteogenic Differentiation By Targeting Osteogenic Genesmentioning

confidence: 95%

MicroRNAs Regulation in Osteogenic Differentiation of Mesenchymal Stem Cells

Han

Fan

2021

Front. Dent. Med

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Mesenchymal stem cells (MSCs) are a kind of pluripotent stem cell with the potential of self-renewal and multidirectional differentiation. They can be obtained from a variety of tissues and can differentiate into a variety of cell types under different induction conditions, including osteoblasts. Because of this osteogenic property, MSCs have attracted much attention in the treatment of bone metabolism-related diseases. MicroRNAs (miRNAs), as an epigenetic factor, are thought to play an important regulatory role in the process of osteogenic differentiation of MSCs. In recent years, increasingly evidence shows that miRNAs imbalance is involved in the regulation of osteoporosis and fracture. In this review, miRNAs involved in osteogenic differentiation and their mechanisms for regulating the expression of target genes are reviewed. In addition, we also discuss the potential clinical applications and possible directions of this field in the future.

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“…After adhesion and proliferation comes the differentiation of cells. MSCs are multiprogenitor cells that can be differentiated into the desired lineage of cells under conditions that stimulate the transition [144,145]. In the case of BTE, these progenitor cells are being used to treat bone defects by differentiating them into osteoblasts and affiliated cells that will aid in the regeneration process.…”

Section: Cell Differentiationmentioning

confidence: 99%

Recent Advancements in Electrospun Chitin and Chitosan Nanofibers for Bone Tissue Engineering Applications

Ganesh,

Anushikaa,

Swetha Victoria

et al. 2023

JFB

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Treatment of large segmental bone loss caused by fractures, osteomyelitis, and non-union results in expenses of around USD 300,000 per case. Moreover, the worst-case scenario results in amputation in 10% to 14.5% of cases. Biomaterials, cells, and regulatory elements are employed in bone tissue engineering (BTE) to create biosynthetic bone grafts with effective functionalization that can aid in the restoration of such fractured bones, preventing amputation and alleviating expenses. Chitin (CT) and chitosan (CS) are two of the most prevalent natural biopolymers utilized in the fields of biomaterials and BTE. To offer the structural and biochemical cues for augmenting bone formation, CT and CS can be employed alone or in combination with other biomaterials in the form of nanofibers (NFs). When compared with several fabrication methods available to produce scaffolds, electrospinning is regarded as superior since it enables the development of nanostructured scaffolds utilizing biopolymers. Electrospun nanofibers (ENFs) offer unique characteristics, including morphological resemblance to the extracellular matrix, high surface-area-to-volume ratio, permeability, porosity, and stability. This review elaborates on the recent strategies employed utilizing CT and CS ENFs and their biocomposites in BTE. We also summarize their implementation in supporting and delivering an osteogenic response to treat critical bone defects and their perspectives on rejuvenation. The CT- and CS-based ENF composite biomaterials show promise as potential constructions for bone tissue creation.

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Resveratrol benefits the lineage commitment of bone marrow mesenchymal stem cells into osteoblasts via miR‐320c by targeting Runx2

Cited by 13 publications

References 57 publications

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

MicroRNAs Regulation in Osteogenic Differentiation of Mesenchymal Stem Cells

Recent Advancements in Electrospun Chitin and Chitosan Nanofibers for Bone Tissue Engineering Applications

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