Resveratrol attenuates malathion-induced renal damage by declining oxidative stress in rats

Abstract

Extensive and uncontrolled use of pesticides and insecticides has long been known as a major environmental problem, to which researchers have been trying to discover an appropriate substitute. [1] Organophosphorus compounds are a sanitary problem around the world that has been reported as the third leading cause of toxicity-induced death. [2] Organophosphorus insecticides have phosphor in their structure and are one of the derivatives of phosphoric acid. [3] The most frequently used organophosphorus compounds include metasystox, malathion, xanthion, and Background: Malathion is the most organophosphates which are capable to produce free radicals and induce disturbance in body antioxidant. Resveratrol is an herbal polyphenol and it has been beneficial antioxidant effects during short-term administration. This study was designed to evaluate the effects of resveratrol against damage induced by malathion to the kidneys of rats. Materials and Methods: Forty-eight Wistar rats divided randomly into eight groups (n = 6): sham (saline) and malathion control treated groups (27 mg/kg); resveratrol groups (2, 8, and 20 mg/kg); and resveratrol + malathion-treated groups (2, 8, and 20 mg/kg). Treatments were administered intraperitoneally and gavage daily for 45 days. Parameters related to the function and the histology of the kidneys were evaluated and statistically analyzed from kidney and blood serum samples in respect of the groups. Results: Malathion administration increased significantly Bowman's space, qualitative histopathology indices, kidney malondialdehyde (MDA) level, blood urea nitrogen (BUN), creatinine, and nitrite oxide levels and decreased significantly total antioxidant capacity (TAC) level and diameter and number of renal corpuscles compared to the Sham group (P < 0.001). The resveratrol and resveratrol + malathion treatments in a dose-dependent manner reduced significantly Bowman's space, qualitative histopathology indices, kidney MDA level, BUN, creatinine, and nitrite oxide levels and increased significantly TAC level and diameter and number of renal corpuscles compared to the malathion control group (P < 0.001). Conclusion: It seems that resveratrol administration in a dose-dependent manner improved kidney injury induced by malathion in rats.

Effects of Royal Jelly on the Prefrontal Cortex in a Rat - Morphine Toxicity Model

“…36 Jalili et al reported that the administration of Resveratrol as an antioxidant decreased total antioxidant capacity in rats treated with Malathion, which is in line with the findings of the present study. 37 In the present study, the improved levels of total antioxidant capacity in rats treated with RJ highlight the antioxidant effects of RJ. 6 The high antioxidant level rise due to the administration of morphine indicates the positive impact of RJ on magnified antioxidant effects.…”

Histopathological and biomedical parameters determination in the protective effect of crocin on hepatotoxicity induced by methotrexate in rats

“…Consistent with these findings, a large body of studies have shown anti-oxidant properties for Cro (11,15,17). Thus, it appears that Cro with its anti-oxidant properties could reduce MDA level and increase FRAP level by inhibition of ROS generation.…”

“…NO is a type of free radical produced in mammalian cells which interfere with the regulation of physiological processes. Elevation of NO production can be associated with the development of different diseases (15). The hydroxyl radicals produced by NO and superoxide anion can cause interference with the process of pathogenesis and hepatotoxicity (17).…”

“…Then, it was centrifuged (3000 rpm) for 15 minutes until the serum was separated. The resultant serum was stored in a -70°C refrigerator as stock for measuring the levels of liver biochemical parameters, nitric oxide, oxidative stress, and antioxidant capacity, Then, at the last stage of dissecting process, the liver was removed and fixed in 10% formalin solution for histological and morphometric investigations (15).…”