RETRACTED ARTICLE: Determination of histopathological and biomedical parameters in protective effects of Petroselinum crispum on hepatotoxicity induced by dichlorvos in male Wistar rats

Salahshoor, Mohammad Reza; Abdolmaleki, Amir; Roshankhah, Shiva; Ziapour, Arash

doi:10.1007/s00580-019-03087-7

Cited by 4 publications

(6 citation statements)

References 32 publications

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“…3 Mitochondria dysfunction, due to the extraordinary consumption of O 2 , may possibly increase the creation of free radicals in most body tissues, including NO radicals, and due to the nitrosative and oxidative stress and damage to the tissues, particularly the hepatic tissue. 7 The results are in contract with of Jalili et al conclusions, which displayed that thymoquinone can condense NO in morphine-induced damage to the hepatic tissue. 6 The consequences are in concurrence with new studies representative that taxol, as one of the chemotherapy medications, is seemingly able to impairment hepatocytes, increase apoptogenic, liver enzymes, NO, LP, and reduce TAC, by inducing oxidative stress.…”

Section: Discussionsupporting

confidence: 85%

“…3 The taxol metabolism made free radicals then it causes LP, DNA, and membrane proteins reaction and subsequently cell impairment through several ways. 7 Thymoquinone, as the antioxidant herb, has an inhibitory effect on cytochrome P450, inhibits additional taxol metabolism and diminish the construction of free radicals. 6 The outcomes of the existing study agree with the consequences of the study of Salahshoor et al, in which they displayed that Genistein administration as a herb antioxidant improves liver damage, resulted in the decreasing diameter of hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

“…It appears that the attack of free radicals to hepatocyte causes apoptosis in parenchymal cells. 7 Kupffer cells can prompt inflammatory reactions in the hepatic tissue, which leads to tissue impairment. 22 Apparently, Kupffer cells are triggered in reply to tissue damage and release mediators, such as the TNF and NO.…”

Section: Discussionmentioning

confidence: 99%

“…The produced dye in the commercial kit was read at 532 nm, and in conclusion, the MDA level was stated in nmol/mg protein. 7…”

Section: Measurement Of Lp Levelsmentioning

confidence: 99%

“…6 One of the most important destructive effects of free radicals is lipid peroxidation (LP), which causes cell membrane injury. 7 These free radicals can induce the production of LP and cellular damages, particularly in hepatic cells by alkylating the protein groups and other cellular macromolecules and attacking unsaturated fatty acids. 8 Oxidative stress plays a vital role in the hepatic tissue impairment induced by toxins and drugs.…”

Section: Introductionmentioning

confidence: 99%

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Administration of Thymoquinone Offer a Protective Effect through the Apoptogenic and Antioxidant Pathway in Acute Liver Failure induced by Taxol

Salahshoor

Roshankhah

Jalili

et al. 2020

J. Contemp. Med. Sci.

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Objectives Due to the increasing use of chemotherapy drug and herbs in medicine, this study was designed to assess the effects of Thymoquinone and Taxol on apoptogenic, oxidative and histomorphometric changes in liver. Methods Sixty-four male rats were assigned to 8 groups including control groups (normal group and Taxol (20 mg/kg group), Thymoquinone groups (4.5, 9, 18 mg/kg) and Taxol + Thymoquinone (TT) treated groups. All experimental groups were treated intraperitoneally daily for two weeks. The relative expression level of apoptotic genes and hepatocyte apoptotic index were analyses. Also, Nitrite oxide (NO), lipid peroxidation (LP), total antioxidant capacity (TAC), hepatic enzymes and histomorphometric parameters were evaluated. Results In the Taxol control group (TCG) all parameters investigated in this study significantly increase except TAC level, which was decreased in compared to the normal control group (NCG) (P < 0.01). Additionally, all evaluated parameters were reduced in Thymoquinone and TT groups, except TAC level (which was increased) as compared to the TCG (P < 0.01). Conclusion Our results discovered that Thymoquinone successfully moderate liver injury induced by Taxol through the activation of antioxidant pathways, reduce the apoptogenic and the regeneration of histopathological alterations.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The produced dye in the commercial kit was read at 532 nm, and in conclusion, the MDA level was stated in nmol/mg protein. 7…”

Section: Measurement Of Lp Levelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Administration of Thymoquinone Offer a Protective Effect through the Apoptogenic and Antioxidant Pathway in Acute Liver Failure induced by Taxol

Salahshoor

Roshankhah

Jalili

et al. 2020

J. Contemp. Med. Sci.

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Date fruit as a promising source of functional carbohydrates and bioactive compounds: A review on its nutraceutical potential

Alvi

Khan

Maan

et al. 2022

Journal of Food Biochemistry

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Antioxidant Potential of Parsley Leaf (Petroselinum crispum) Essential Oil on Hypothyroidism and Testicular Injury in Mice Intoxicated by Carbon Tetrachloride

Badr

Algefare

Alfwuaires

2021

BioMed Research International

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The aim of the present study was to investigate the ameliorative potential of parsley (Petroselinum crispum) leaf essential oil (PO) against the detrimental effects of carbon tetrachloride (CCl4) on the thyroid gland and testes of mice. Twenty-four adult male mice were divided into four groups and treated for 4 weeks. The 1st control group received 3 mL/kg olive oil intraperitoneally, twice a week followed by 0.5 mL/kg saline intragastrically daily. The 2nd CCl4 group received CCl4 (3 mL/kg intraperitoneally, twice a week). The 3rd PO group received PO (0.5 mL/kg intragastrically daily), while the 4th CCl4+PO group received CCl4 coadministrated with PO at the aforementioned doses. CCl4 group recorded significant ( p < 0.05 ) reduction in the activities of antioxidant enzyme catalase (CAT) and superoxide dismutase (SOD) and significant ( p < 0.05 ) increase in the lipid peroxidation end product’s level malondialdehyde (MDA) in the testes and thyroid glands. Meanwhile, serum levels of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid hormones (thyroid-stimulating hormone (TSH), total triiodothyronine (T3), free triiodothyronine (fT3), total thyroxine (T4), and free thyroxine (fT4)) significantly decreased. Also, histopathologically, the testicular tissue showed hypospermatogenesis within irregular-shaped seminiferous tubules with prominent edema in the interstitial spaces confirming the aforementioned biochemical alterations. Treatment with PO significantly reduced the testicular and thyroid oxidative stress ( p < 0.05 ) and elevated the testosterone (73.47%), FSH (92.11%), LH (33.33%), T3 (23.47%), fT3 (39.13%), T4 (27.91%), and fT4 (75%) as compared to that of CCl4-treated group corresponding values. The PO GC/MS analysis indicated bioactive monoterpenes (major component is 1,3,8-mentha triene 34.48%) and phenylpropenes (major component is myristicin 21.04%). Results suggested the ameliorative effect of PO against CCl4-induced hypogonadism in mice by suppressing oxidative stress and maintaining thyroid gland function.

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RETRACTED ARTICLE: Determination of histopathological and biomedical parameters in protective effects of Petroselinum crispum on hepatotoxicity induced by dichlorvos in male Wistar rats

Cited by 4 publications

References 32 publications

Administration of Thymoquinone Offer a Protective Effect through the Apoptogenic and Antioxidant Pathway in Acute Liver Failure induced by Taxol

Administration of Thymoquinone Offer a Protective Effect through the Apoptogenic and Antioxidant Pathway in Acute Liver Failure induced by Taxol

Date fruit as a promising source of functional carbohydrates and bioactive compounds: A review on its nutraceutical potential

Antioxidant Potential of Parsley Leaf (Petroselinum crispum) Essential Oil on Hypothyroidism and Testicular Injury in Mice Intoxicated by Carbon Tetrachloride

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