Resveratrol attenuates lipopolysaccharide‐induced acute kidney injury by suppressing inflammation driven by macrophages

Liang, Chao; Yang, Sixing; Zumbrun, Elizabeth E.; Guan, Hongbing; Nagarkatti, Prakash; Nagarkatti, Mitzi

doi:10.1002/mnfr.201400819

Cited by 94 publications

(77 citation statements)

References 48 publications

(70 reference statements)

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“…And it has been suggested that the in vivo biological activity of equimolar doses of Pte may be greater than that of resveratrol (6), and the antioxidant activity of Pte are superior to resveratrol due to its higher lipophilicity, which increases its ability to be absorbed compared to resveratrol (6). Studies have demonstrated that resveratrol has salutary effect on sepsis-induced multiple organ dysfunction, such as myocardial depression (7), AKI (8)(9)(10). However, the effect of Pte on sepsis-induced AKI remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Pterostilbene attenuates acute kidney injury in septic mice

et al. 2018

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Abstract. Acute kidney injury (AKI) is a severe complication of sepsis with a high mortality and morbidity. Pterostilbene (Pte) has been suggested to confer anti-apoptotic and anti-inflammatory effects. In the current study, the effects of Pte on AKI were evaluated in septic mice. Cecal ligation and puncture surgery was performed to induce sepsis. The results suggested that Pte administration significantly decreased the levels of serum urea nitrogen and creatinine, and improved the survival rate of septic mice. Additionally, the renal injury induced by sepsis was attenuated by pterostilbene treatment. Notably, pterostilbene reduced Bcl-2-associated X protein expression, and levels of interleukin-1β and tumor necrosis factor-α, and upregulated B-cell lymphoma 2 expression. The results indicate that pterostilbene may serve as a potential therapeutic candidate for the treatment of AKI induced by sepsis.

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Section: Introductionmentioning

confidence: 99%

Pterostilbene attenuates acute kidney injury in septic mice

et al. 2018

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“…In fact, TNF-α and Fas-ligand bind directly to tubular cell receptors, promoting the activation of caspase-8 and inducing apoptosis [21]. Furthermore, in recent experimental animal models the exposure to LPS was associated to a significant increase in vacuolar degeneration, renal cell apoptosis and neutrophils and macrophages infiltration [22][23][24][25]. In particular, Langford et al observed in vitro multiple caspase activation in rabbit kidney cells treated with LPS, suggesting the stimulation of the extrinsic, intrinsic and endoplasmatic reticulum/stress apoptotic pathways [26].…”

Section: Evaluation Of Plasma Immunemediated Moleculesmentioning

confidence: 99%

Cardiorenal Syndrome Type 5 in Sepsis: Role of Endotoxin in Cell Death Pathways and Inflammation

Virzì

Clementi

Brocca

et al. 2016

Kidney Blood Press Res

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Background/Aims: Cardiorenal Syndrome Type 5 (CRS Type 5) is characterized by concomitant cardiac and renal dysfunction in the setting of different systemic disorders, such as sepsis. In this study, we investigated the possible relationship between endotoxin levels, renal cell death and inflammation in septic patients with CRS Type 5. Methods: We enrolled 11 patients with CRS Type 5. CRS Type 5 was defined according to the current classification system. AKI was defined by Acute Kidney Injury Network (AKIN) criteria. Acute cardiac dysfunction was documented by echocardiography as acute left and/or right ventricular dysfunction leading to decreased ejection fraction. Endotoxin activity was measured by the Endotoxin Activity Assay (EAA). Plasma from CRS Type 5 patients was incubated with renal tubular cells (RTCs) and cell death levels were evaluated. Plasma cytokines levels were measured as well. Results: Accordingly to EAA levels, patients were divided into two groups: 45.4% of patients had low endotoxin activity level (negative EAA), while 54.5% of patients showed high endotoxin activity (positive EAA). RTCs incubated with plasma from EAA positive patients showed significantly higher apoptosis levels and higher caspase-3 activation compared to cells incubated with plasma from EAA negative patients, and a significant positive correlation was observed between EAA levels and RTC apoptosis levels. Furthermore, IL-6 and IFN-γ levels were significantly higher in CRS Type 5 patients with positive EAA. Conclusion: Our data suggest a possible relationship between endotoxin levels and renal cell death in septic patients with CRS Type 5. Furthermore, this study highlights the presence of renal apoptosis, the immune deregulation and the strong inflammation in CRS Type 5 patients, especially in those with high endotoxin activity.

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“…Resveratrol might still exhibit its beneficial effects during recovery by reduction of oxidative stress [29, 48] and suppression of inflammation at later phases than analyzed in our short term model [30, 48]. The reduction in pCysC might point towards that, but a reperfusion time aiming to answer this question is far beyond the scope of the current study.…”

Section: Discussionmentioning

confidence: 78%

Resveratrol Does Not Protect from Ischemia-Induced Acute Kidney Injury in an in Vivo Rat Model

Bienholz

Pang

Guberina

et al. 2017

Kidney Blood Press Res

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Background/Aims: The natural polyphenol resveratrol (RSV) has been shown to ameliorate ischemia/reperfusion (I/R)-induced damage. Therefore, a rat model of I/R-induced AKI equipped with intensive monitoring was utilized to examine direct renal protection by RSV in vivo. Methods: AKI was induced by bilateral renal clamping (45 min) followed by reperfusion (3 h). Solvent-free RSV was continuously infused intravenously (0.056 and 0.28 mg/kg) in a total volume of 7 ml/kg/h starting from 30 min before renal clamping. At a mean arterial blood pressure below 70 mmHg for more than 5 min, bolus injections of 0.5 ml 0.9% NaCl solution were administered repetitively (max. 5 ml/kg/h). Results: No differences could be found between normoxic control groups with/without RSV. Bilateral renal clamping and subsequent reperfusion caused a progressive rise in creatinine, cystatin C, and CK, a decrease in cellular ATP content and diuresis. Infusion of RSV increased sirtuin 1 expression after ischemia/reperfusion and was associated with decreased blood pressure during ischemia and early reperfusion accompanied by an increased requirement of bolus injections as well as with increased expression of TNFα. Conclusion: RSV did not exert protective effects on I/R-induced AKI in the present short-term in vivo rat model. The lack of protection is potentially connected to aggravation of blood pressure instability.

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Resveratrol attenuates lipopolysaccharide‐induced acute kidney injury by suppressing inflammation driven by macrophages

Cited by 94 publications

References 48 publications

Pterostilbene attenuates acute kidney injury in septic mice

Pterostilbene attenuates acute kidney injury in septic mice

Cardiorenal Syndrome Type 5 in Sepsis: Role of Endotoxin in Cell Death Pathways and Inflammation

Resveratrol Does Not Protect from Ischemia-Induced Acute Kidney Injury in an in Vivo Rat Model

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