Resveratrol as an anti-asthmatic agent: could this stilbenoid help against COVID-19 in any way? A meta-analysis

Abstract

Resveratrol is a phenolic phytoconstituent found in many plants. This molecule has always caught the attention of scientists because of biological potentials such as inhibition of inflammation, oxidative stress and platelet aggregation as well as to prevent/protect against cardiovascular and neurodegenerative disease/disorders. Literature search have been conducted over resveratrol in covid-19 and asthma studies published in Pubmed and Google Scholars until 30 September 2020. The criteria used in the literature review were determined and were reviewed works on resveratrol including 368 articles and 47 articles on covid-19 and asthma, respectively. As a result of meta-analysis, TNF-α values of the studies showed a significant difference (heterogeneity) of I2=68.39% from each other in total (Cohran Q:6.33, p<0.0423). This study shows that resveratrol would have a potential to reduce ARDS symptoms, by suppressing the cytokine storm and severe inflammation caused by SARS-CoV-2, and by showing strong activity against various types of DNA/RNA viruses.

An outlook on the target‐based molecular mechanism of phytoconstituents as immunomodulators

“…In a recent meta‐analysis, resveratrol effectively lowers cytokine storms and inflammation in coronavirus disease‐19 (COVID‐19). Additionally, it modulates the pathways involved in antiviral defense (Parlar et al, 2021). The preclinical data of resveratrol highlights its role as an immunomodulator, but more clinical trials must be conducted to confirm its potential.…”

Plant-based Immunomodulators and Their Potential Therapeutic Actions

“…Resveratrol has been tested in clinical trials for patients with type 2 diabetes, nonalcoholic fatty liver syndrome, or polycystic ovary syndrome by modulating the expression of transcription factors and cytokines in circulating immune cells. 83,84 Additionally, a recent meta-analysis concluded that resveratrol treatment effectively reduces inflammation and cytokine storms as well as regulates pathways involved in antiviral defense in COVID-19 patients 85.…”