Resveratrol and insulin association reduced alveolar bone loss and produced an antioxidant effect in diabetic rats

Cirano, Fabiano Ribeiro; Molez, Andréia Manetta; Ribeiro, Fernanda Vieira; Tenenbaum, Howard C.; Casati, Márcio Zaffalon; Corrêa, Mônica Grazieli; Pimentel, Suzana Peres

doi:10.1002/jper.19-0718

Cited by 14 publications

(15 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RSV inflammatory, and even anti-cancer qualities [74,7 DP has been explored in three animal studies and 2. All investigations agreed on the anti-inflamm three confirmed its anti-diabetic [18,20,21] capab these studies revealed a remarkable attenuation cytokines, and improved fasting blood glucose lev approach for reducing bone resorption and impro…”

Section: Resveratrolmentioning

confidence: 64%

“…The therapeutic potential of RSV for DP has been explored in three animal studies and two clinical trials, as tabulated in Table 2. All investigations agreed on the anti-inflammatory effects of RSV [18,20,21,76], and three confirmed its anti-diabetic [18,20,21] capabilities for managing DP. The results of these studies revealed a remarkable attenuation of bone loss, reduced inflammatory cytokines, and improved fasting blood glucose levels, so it can be considered an effective approach for reducing bone resorption and improving metabolic management.…”

Section: Resveratrolmentioning

confidence: 67%

“…To this end, this review includes all animal and clinical studies that have reported outcomes for natural compounds in DP. To date, the natural compounds that can modulate DP are resveratrol [17][18][19][20][21], curcumin [22][23][24][25][26][27], melatonin [28][29][30][31][32], propolis [33][34][35], vitamin C [36][37][38], green tea [39][40][41], ginger [42], aloe vera [43], rutin [26], and vitamin E [44]. Thus, this review will cover the pathogenesis of DP and the therapeutic effects of the above mentioned extracts on DP.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

Lin

Chao

et al. 2022

JCM

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a major worldwide health burden. DM is a metabolic disease characterized by chronic hyperglycemia, and if left untreated, can lead to various complications. Individuals with uncontrolled DM are more susceptible to periodontitis due to both a hyper-inflammatory host response and an impaired immune response. Periodontitis, on the other hand, may exacerbate DM by increasing both local and systemic inflammatory components of DM-related complications. The current standard for periodontal treatment in diabetes-associated periodontitis (DP) focuses mostly on reducing bacterial load and less on controlling the excessive host response, and hence, may not be able to resolve DP completely. Over the past decade, natural compounds have emerged as an adjunct approach for modulating the host immune response with the hope of curing DP. The anti-oxidant, anti-inflammatory, and anti-diabetic characteristics of natural substances are well-known, and they can be found in regularly consumed foods and drinks, as well as plants. The pathophysiology of DP and the treatment benefits of various bioactive extracts for DP will be covered in this review.

show abstract

Section: Resveratrolmentioning

confidence: 64%

Section: Resveratrolmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

Lin

Chao

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…1.5 × 10 -3 % hydrogen peroxide solution can decrease the survival rate of gingival fibroblasts and promote the secretion of TNF-α by gingival fibroblasts, which can be inhibited by non-enzymatic antioxidant α-tocopherol (vitamin E) [23]. The combination of resveratrol and insulin can reduce the level of pro-inflammatory factors and increase the level of SOD, thereby inhibiting the progress of experimental periodontitis, and reducing the loss of alveolar bone, which has a beneficial effect on the repair of bone tissue [24]. Some scholars collected serum and gingival specimens by local injection of vitamin C into the subgingival periosteum of male SD rats [25].…”

Section: Role Of Antioxidants In Periodontitismentioning

confidence: 99%

The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis

Lin¹,

Wu²,

Chen³

et al. 2022

CMR

View full text Add to dashboard Cite

Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 -related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation.

show abstract

“…Antioxidant compounds, such as resveratrol, quercetin, and curcumin, are increasingly proposed to rebalance the oxidative stress-loaded environment at the ground of multiple diseases (Sczepanik et al 2020). In an experimental periodontitis model in diabetic rats, systemic resveratrol reduced NADPH-oxidase levels in the gingiva, upregulated mRNA levels for osteoprotegerin, and reduced the progression of periodontitis independently from insulin treatment (Cirano et al 2020). Quercetin is a flavonoid, which has potent anti-inflammatory, antibacterial, and antioxidant effects.…”

Section: Pharmaceutical Interventionsmentioning

confidence: 99%

Periodontitis and Accelerated Biological Aging: A Geroscience Approach

et al. 2021

View full text Add to dashboard Cite

As the whole world is epidemically aging, the burden of periodontitis and tooth loss is becoming a major health concern. Growing meta-epidemiological data implicate chronic systemic inflammation/infection due to periodontitis as an independent risk factor for aging-related diseases and mortality. However, because people age differently, chronological age is not a reliable marker of an individual’s functional status. Recent advances in geroscience have shown that various biomarker signatures of biological aging are longitudinally associated with declined physical function, morbidity, and mortality due to major age-related diseases, including periodontitis. Here, we emphasize novel research developments bidirectionally linking periodontitis to accelerated biological aging. Using a composite biomarker age estimator, a striking increase in periodontitis and tooth loss was observed in subjects whose biological age at baseline was higher than their chronological age. Moreover, significantly shortened telomeres were encountered in populations affected by severe periodontitis. Second, we elucidate the cellular and molecular pillars of the aging process at the periodontal level. Accumulating evidence suggests that cellular senescence, stem cell exhaustion, and immunoaging are hallmarks of biological aging implicated in the impairment of periodontal homeostasis and the pathophysiology of periodontitis. Indeed, persistent bacteria-derived lipopolysaccharide stimulation influences cellular senescence in osteocytes, driving alveolar bone resorption. Moreover, inflammaging status induced by chronic hyperglycemia elevates the burden of senescent cells in gingival tissues, impairing their barrier function. Lastly, we reviewed a recent breakthrough in senotherapy to directly target the mechanisms of aging at the periodontal level. Physical exercise and intermittent fasting, together with natural compounds, senolytic drugs, and cell therapy, are increasingly being evaluated to rejuvenate the oral cavity. Following these innovations in geroscience, further advancements could provide oral clinicians the chance to intercept biological aging when still “subclinical” and set interventions for halting or delaying the trajectory toward aging-related diseases while patients are still chronologically young.

show abstract

Resveratrol and insulin association reduced alveolar bone loss and produced an antioxidant effect in diabetic rats

Cited by 14 publications

References 58 publications

Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis

Periodontitis and Accelerated Biological Aging: A Geroscience Approach

Contact Info

Product

Resources

About