Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

Abstract

Diabetes mellitus (DM) is a major worldwide health burden. DM is a metabolic disease characterized by chronic hyperglycemia, and if left untreated, can lead to various complications. Individuals with uncontrolled DM are more susceptible to periodontitis due to both a hyper-inflammatory host response and an impaired immune response. Periodontitis, on the other hand, may exacerbate DM by increasing both local and systemic inflammatory components of DM-related complications. The current standard for periodontal treatment in diabetes-associated periodontitis (DP) focuses mostly on reducing bacterial load and less on controlling the excessive host response, and hence, may not be able to resolve DP completely. Over the past decade, natural compounds have emerged as an adjunct approach for modulating the host immune response with the hope of curing DP. The anti-oxidant, anti-inflammatory, and anti-diabetic characteristics of natural substances are well-known, and they can be found in regularly consumed foods and drinks, as well as plants. The pathophysiology of DP and the treatment benefits of various bioactive extracts for DP will be covered in this review.

Beneficial Effects of a Blended Fibroin/Aloe Gel Extract Film on the Biomolecular Mechanism(s) via the MAPK/ERK Pathway Relating to Diabetic Wound Healing

“…We proposed that the film extract via its functional components, Aloe vera and fibroin, acts through the common MAPK/ERK signaling pathway. Nevertheless, according to the literature, it should regulate other signaling molecules and processes involved in dynamic signaling crosstalk, such as the NF - κB signaling system. , …”

“…Nevertheless, according to the literature, it should regulate other signaling molecules and processes involved in dynamic signaling crosstalk, such as the NF-κB signaling system. 42,43 Our previous clinical study indicated the wound healing efficacy of the blended fibroin/aloe gel extract film. 13 The film could accelerate the healing rate of diabetic foot ulcers after application for 4 weeks, implying the sufficient delivery of the bioactive compounds from the film to the wound site.…”

“…Nevertheless, according to the literature, it should regulate other signaling molecules and processes involved in dynamic signaling crosstalk, such as the NF - κB signaling system. 42 , 43 …”

Visualized analysis of hotspots and frontiers in diabetes-associated periodontal disease research: a bibliometric study

“…Diabetes-associated periodontal disease usually refers to diabetes-associated periodontitis (DP), a host immune response caused by interaction between periodontopathic bacteria and the host. To some degree, it aggravates diabetic complications and increases the course of periodontitis ( 2 ).…”