Resveratrol and Colorectal Cancer: A Molecular Approach to Clinical Researches

Abstract

: Phytochemicals are the most valuable and comprehensive structures, which may have a broad range of protective benefits, from reducing inflammation and speeding healing to preventing infection and fighting cancer. Resveratrol (RSV) is a natural phenolic compound from the oligomeric stilbenoid group, which is usually found in human daily diets such as grape, peanut, berries and grains. It exhibits anti-inflammatory, neuroprotection, antioxidant and cancer prevention and treatment effects. RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS, BMP7, COX-2, NO, Caspases, Wnt, TNFs, NF-κB, EMT, and pentose phosphate pathway. Therefore, this paper reviews the current researches on resveratrol pharmacological effects and pharmacokinetic and drug delivery system, as well as clinical studies in CRC.

Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer

“…Res is well known as a naturally occurring polyphenol with several therapeutic properties such as cardioprotective, neuroprotective, chemopreventive, and antiaging activities. Several in vitro and in vivo studies have assessed the effectiveness of Res as a candidate treatment against breast cancer, lung cancer, prostate cancer, pancreatic cancer, and leukemia [ 7 , 8 ].…”

“…Resveratrol (Res) is a Stilbene molecule (3,5,4′-trihydroxystilbene) belonging to the polyphenol family that is extracted from many natural plants, particularly grapes. Systemic oral administration of Res can result in its accumulation in various tissues (e.g., the liver, intestine, and stomach) and cancerous tumors through its circulation in the plasma [ 7 ].…”

A Micro-Immunotherapy Sequential Medicine MIM-seq Displays Immunomodulatory Effects on Human Macrophages and Anti-Tumor Properties towards In Vitro 2D and 3D Models of Colon Carcinoma and in an In Vivo Subcutaneous Xenograft Colon Carcinoma Model

“…In parallel, due to their promising health benefits, natural polyphenols, such as RSV, have also been extensively researched as other alternatives to chemotherapy but again, their toxicity and side effects issues still need to be addressed [ 5 ]. Particularly in CRC, the anti-cancer properties of RSV are promising and are under investigation in clinical studies [ 70 ]. In addition to its anti-cancer effects, RSV also displays a wide range of pharmacological activities, including neuroprotection, antioxidation and anti-inflammatory effects [ 71 ].…”

“…In the context of CRC, RSV exhibited the ability to interfere with the signaling pathways involved in the initiation and progression of this cancer, including silent mating type information regulator two homolog 1 (SIRT1), P53, P21, AMP-activated protein kinase (AMPK), reactive oxygen species (ROS), cyclooxygenase (COX) 2, nitric oxide (NO), caspases, wingless-related integration site (Wnt), TNFs, and nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) signaling [ 70 ]. Interestingly, while COXs are important regulators of inflammation and angiogenesis, they are also implicated in carcinogenesis, as the overexpression of COX-2 has been reported as one of the causative factors for CRC development [ 74 ].…”

Curcumin- and resveratrol-co-loaded nanoparticles in synergistic treatment of hepatocellular carcinoma

“…Similarly, RSV is a natural antioxidant polyphenolic compound that is found in a variety of plants, such as those that produce grapes, peanuts, and berries [ 14 ]. Recent studies have suggested that RSV can prevent or inhibit the development of breast [ 15 ], colorectal [ 16 ], pancreatic [ 17 ], prostate [ 18 ], and liver cancers [ 19 ]. For example, RSV inhibits breast cancer cell proliferation by regulating the STAT3 signalling cascade via its antioxidant and anti-inflammatory effects [ 20 ].…”