Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer

Amplifying endogenous stem cell migration for in situ bone tissue formation: Substance P analog and BMP mimetic peptide-loaded click-crosslinked hyaluronic acid hydrogel

“…To prepare the Cx-HA, firstly the TE-HA and TC-HA were prepared according to previous work as described in the Supporting Information [ 19 ]. Then, the prepared TE-HA and TC-HA were each dispersed in PBS (pH 7.4) to a final concentration of 20 mg/mL.…”

“…This is achieved through a biorthogonal Diels–Alder click crosslinking reaction between tetrazine (TE) and transcyclooctene (TC) to create a click crosslinked-hyaluronic acid (Cx-HA) hydrogel scaffold. This scaffold, formed by mixing TE-HA and TC-HA, exhibits prolonged residence times under physiological conditions [ [19] , [20] , [21] ].…”

Hyaluronic Acid-Mediated Phenolic Compound Nanodelivery for Cancer Therapy

“…Then, according to the same classification, among the dietary PheCs have also been included the 2 less-abundant groups of the Stilbenes and Lignans ( Figure 1 ), and finally, under the name of Other Polyphenols , a series of 80 compounds among which there is the curcuminoid curcumin (CUR), which has been largely reported to have a prominent antioxidant and anticancer activity [ 59 ] ( Figure 1 ). In particular, stilbene resveratrol [ 60 , 61 , 62 , 63 ] and curcuminoid curcumin [ 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ] are the non-flavonoids that have been so far included in HA-coated delivery systems for possible cancer targeting.…”

“…Among the three different HA- and RES-containing nanosystems that have been recently investigated against BCa, two were HA-coated NPs [ 61 , 62 ], and one was an HA-based hydrogel [ 63 ]. In one case [ 61 ], the nanoformulation carried RES together with tamoxifen and was tested both on TNBC cells (CAL-51) and on estrogen and progesterone receptor-expressing BCa cells (MCF7 cells).…”

Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

“…Colorectal peritoneal carcinomatosis chemotherapy [ 199] Injectable hydrogel Amine derivative of HA and vinylsulfone functionalized 𝛽-CD complexing doxorubicin Anticancer drug Localized chemotherapy of solid tumors [ 200] Injectable hydrogel Iron sulfate, HA-CA Glucose oxidase Shear-thinning and self-healing characteristics Multiple therapy of localized breast cancer [ 201] Injectable hydrogel Mn 2+ hydrazide HA Catalase-like activity, stimuli-responsiveness and self-healing capacity Oxygen-enhanced dual-phototherapy for breast cancer [ 202] Injectable hydrogel Metformin grafted OHA, carboxymethyl CS pH-responsive behavior Preventing breast cancer recurrence [ 203] Injectable hydrogel Tetrazine-modified HA, trans-cyclooctene -modified HA Resveratrol Therapeutic improvement in triple negative breast cancer [ 204] (Continued) Chemo-photodynamic therapy [ 205] Injectable hydrogel Juxtamembrane 2 grafted HA Inhibit tumor recurrence Postsurgical tumor treatment [ 206] Injectable hydrogel HA-PBA, HA-dopamine Erlotinib Shear-thinning behavior, self-healing property, lower toxicities to healthy organs Local cancer therapy [ 207] Injectable hydrogel HA-CA, Cupric sulfate Indocyanine green NIR response Local CDT and PTT of breast cancer [ 208] Injectable hydrogel HA aldehyde and the carboxymethyl chitosan…”