Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

Abstract

Hyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent pharmacological properties and versatile chemical groups for modification. Due to their water retention ability, biocompatibility, biodegradation, cluster of differentiation‐44 targeting, and highly designable capacity, HA hydrogels have been an emerging biomaterial, showing tailoring performance in terms of chemical modifications and hydrogel forms. Various preparation technologies have been developed for the fabrication of the tailoring HA hydrogels with unique structures and functions. They have been utilized in diverse biomedical applications like drug delivery and tissue engineering scaffolds. Herein, this review comprehensively summarizes the HA derivatives with different molecule weights and functional modifications. Then the various fabrication methods to obtain tailoring hydrogels in the forms of nanogel, nanofiber, microparticle, microneedle patch, injectable hydrogel, and scaffold are reviewed as well. The emphasis is focused on the shining biomedical applications of these tailoring HA hydrogels in anti‐bacteria, anti‐inflammation, wound healing, cancer treatment, regenerative medicine, psoriasis treatment, diagnosis, etc. The potentials and prospects are subsequently given to inspire further investigation, aiming at accelerating product translation from research to clinic.

Flexible Conformally Bioadhesive MXene Hydrogel Electronics for Machine Learning‐Facilitated Human‐Interactive Sensing

“…As a crucial structural and bioactive component in the skin extracellular matrix, featuring excellent hydrophilicity from large amounts of hydroxyl and carboxyl groups (Figure 1d), good biocompatibility, outstanding water retention ability, robust biodegradability, enhanced cell adhesion, and facile chemical modification, HA is utilized in wound dressings to facilitate hemostasis. [ 48 ] The successful preparation of HA‐PBA was verified by 1 HNMR spectra (Figure S3, Supporting Information). Notably, as a vasoconstrictor in the process of blood coagulation, the catechol groups of TA could also promote hemostasis.…”

Advances in Formulations of Microneedle System for Rheumatoid Arthritis Treatment

“…Sugars, including hyaluronic acid, chitosan, and dextran, among many others, are the major materials that are used to produce dissolving MNs. 132 Hyaluronic acid has been extensively studied in drug delivery applications 133 and is recognized as biocompatible and safe. In addition, MNs also have an excellent safety performance for skin tissues.…”

Wound microenvironment self-adaptive all-in-one hydrogel for rapid healing of the diabetic wound

“…However, these natural hydrogels exhibit poor mechanical properties, low extraction rates, and high costs. 9,10 Additionally, most of these natural hydrogels only have a single function, such as simple anti-inflammatory, hemostatic, or moisture retention, which cannot meet the clinical requirements of chronic wound healing. Recently, the use of smart hydrogels has become a promising strategy for the treatment of diabetic wounds.…”