Resveratrol and cardiovascular health – Promising therapeutic or hopeless illusion?

Tang, Philip Chiu Tsun; Ng, Yam Fung; Ho, Siu Lau; Gyda, Michael; Chan, Shun‐Wan

doi:10.1016/j.phrs.2014.08.001

Cited by 79 publications

(40 citation statements)

References 325 publications

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“…Besides antimicrobial and antioxidant properties, resveratrol has been found to exert a wealth of pharmacological actions, such as anti-inflammatory, anticancer/proapoptotic, chemopreventive, antiangiogenic, and immunomodulatory [8,9]. Recently, but on the basis of a review concerning mainly studies in cell culture and animal models [14], a controversy has recently arisen concerning the potential benefits of resveratrol for human health [15]. As a consequence of the huge body of in vitro and in vivo findings a lot of effort has been engaged in the elucidation of the underlying mechanisms of resveratrol action.…”

Section: Resultsmentioning

confidence: 99%

Enrichment of Resveratrol in Wine through a New Vinification Procedure

Pastor¹,

Gargantini²,

Murgo³

et al. 2015

JLS

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Sulphur dioxide is used in the vinification process as an antimicrobial agent, but it is also considered as an important risk factor for liver diseases. Stilbenes have inhibitory effects on the growth of lactic acid bacteria strains isolated from wine. The authors investigated the viability of obtaining free-SO 2 resveratrol-enriched red wines. Substitution of sulfite (7 g/100kg) for resveratrol (150 mg/L and 300 mg/L) in the vinification process did not change the basic physical and chemical properties of wine or its sensorial profile. To the best of the authors' knowledge this is the first time that this type of vinification procedure is reported.

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Section: Resultsmentioning

confidence: 99%

Enrichment of Resveratrol in Wine through a New Vinification Procedure

Pastor¹,

Gargantini²,

Murgo³

et al. 2015

JLS

View full text Add to dashboard Cite

show abstract

“…Furthermore, resveratrol has been further shown to protect coronary endothelial cells against oxidative stress: in fact, it may stimulate in a dose-dependent manner SIRT1 deacetylase activity by increasing its binding affinity to both the acetylated substrate and NAD + (Howitz et al 2003). Resveratrol-induced SIRT1 activation also appears to mediate protection against ischemia/reperfusion injury by reducing ROS production, switching cardiac myosin heavy chain isoforms to the more stress-resistant forms, inhibiting hypoxia-induced apoptosis, and modulating mitogen-activated protein kinase (MAPK) pathways (Becatti et al 2012;Tang et al 2014). Ischemic preconditioning (IPC) is a powerful endogenous mechanism of protection against myocardial ischemia/reperfusion activated by repetitive brief periods of ischemia and reperfusion.…”

Section: The Sirtuin Familymentioning

confidence: 99%

Sirtuins, aging, and cardiovascular risks

Favero

Franceschetti

Rodella

2015

AGE

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The sirtuins comprise a highly conserved family proteins present in virtually all species from bacteria to mammals. Sirtuins are members of the highly conserved class III histone deacetylases, and seven sirtuin genes (sirtuins 1-7) have been identified and characterized in mammals. Sirtuin activity is linked to metabolic control, apoptosis, cell survival, development, inflammation, and healthy aging. In this review, we summarize and discuss the potential mutual relations between each sirtuin and cardiovascular health and the impact of sirtuins on oxidative stress and so age-related cardiovascular disorders, underlining the possibility that sirtuins will be novel targets to contrast cardiovascular risks induced by aging.

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“…However, there are evidences, which indicates resveratrol as an agent providing protection against metabolic stresses induced by high-fat diets or other oxidative reasons in several species, including human, and as a result, presumably extending life span significantly beyond that expected under conditions of such stress. 50 Unfortunately such a statement is far from admittedly since there are sparse clinical evidences confirming these effects in humans. Clearly, further studies are required to understand the effect of ROS on basic cellular functions and the differential responses seen in different cell types and how this in turn impacts on the pathology of different disease states.…”

Section: Anti-oxidant Effects Of Resveratrolmentioning

confidence: 99%

Untitled

2015

IJPSR

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ABSTRACT:Resveratrol, an antioxidant found in red wine and certain foods, has been touted as a natural way to slow aging and fight cancer, obesity, heart disease, and diabetes. It also could be accounted as an agent, which has effects to reduced risk of inflammation and blood clotting. In addition there are some studies showing that resveratrol may actually reduce the positive effect of exercise on the heart in older men, but it's important to know that its effects only last a short time after drinking red wine. As promising as it sounds, it is not yet established how resveratrol affects humans, since most studies have been conducted on animals and microbes. Because the information on resveratrol, presented in literature, pointing its health and adverse effects is full with contradictions, especially with respect to the human response, we tried to present the available information with minimal commentary, remaining as neutral as possible and allowing the reader to draw its own conclusion on recommendation of the wide increase usage of resveratrol and a prematurity of such a decision.

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Resveratrol and cardiovascular health – Promising therapeutic or hopeless illusion?

Cited by 79 publications

References 325 publications

Enrichment of Resveratrol in Wine through a New Vinification Procedure

Enrichment of Resveratrol in Wine through a New Vinification Procedure

Sirtuins, aging, and cardiovascular risks

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