Resveratrol and Analogues: A Review of Antioxidant Activity and Applications to Human Health

Abstract

Resveratrol has been extensively researched for its powerful antioxidant capacity and other biological effects. The number of patents involving this compound has been growing in recent years. However, the biggest problem associated with this molecule, a limited bioavailability due to its fast metabolism in the liver, has led to obtaining its analogues or derivatives. In this work, we selected patents which describe the application of the antioxidant activity of resveratrol and its analogues as food for the human segment.

Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells

“…Intriguingly, ROS could induce autophagy in resveratrol-treated OVCAR-3 cells [17]. Resveratrol is known to have beneficial antioxidant effects on healthy cells [18], but these antioxidant activities have different consequences in highly proliferating cancer cells. Antioxidants, including resveratrol, have been shown to contribute to ROS-induced cell death in other cancer cell types [19, 20].…”

Kobophenol A Inhibits Sodium Nitroprusside-Induced Cardiac H9c2 Cell Death through Suppressing Activation of JNK and Preserving Mitochondrial Anti-apoptotic Bcl-2 and Mcl-1

“…In this study, RSV showed a cellular protective effect against SNP insults but the protection was weaker than that of Kob A. RSV has been known as a powerful antioxidant but it also has other biological effects. 19) The protective potential of RSV and Kob A may not be completely attributed to its antioxidant capacity, since the two powerful free radical scavengers PTIO and 2-MPG did not show any beneficial effect on SNP toxicity in our experimental setting.…”

“…To exclude the potential involvement of NO and to find the direct cellular damaging moiety caused by SNP in H9c2 cells, the effects of deferoxamine (DFO; an iron chelating agent, 50 µM), 16) 2-mercaptopropionylglycine (2-MPG; a reactive oxygen species (ROS) scavenger, 300 µM), 17) (PTIO; a NO scavenger, 100 µM), 18) resveratrol (phytoestrogen with ROS scavenging activity, 50 µM) 19) on SNP-triggered H9c2 cells death were tested (Fig. 5).…”

An economical and efficient technology for the extraction of resveratrol from peanut (Arachis hypogaea) sprouts by multi-stage countercurrent extraction

“…Over the past three decades, the plant polyphenols have gained significant worldwide interest based on a number of associated health benefits (Frémont, 2000;Petrovski, Gurusamy, & Das, 2011;Smoliga, Baur, & Hausenblas, 2011), including anti-oxidant, anti-cancer, anti-viral, anti-inflammatory, cardioprotective and neuroprotective properties. Recent studies have shown that resveratrol is emerging as a very promising functional ingredient, which might be be incorporated into a number of pharmaceutical and functional food products (Gülçin, 2010;Santos, Carvaho-Gustavo, Oliveira, Raposo-Nadia, & Silva, 2013). Peanut sprouts prepared from the germination of peanut kernels have been used in the diet as health food for several centuries.…”