Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio)

Ran, Gai; Li, Ying; Lin, Li; Yan, Qiaoqiao; Wu, Yi; Ying, Chenjiang; Wang, Hongmei; Ye, Xiaolei

doi:10.1371/journal.pone.0180865

Cited by 52 publications

(39 citation statements)

References 44 publications

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“…Our future study should confirm their exact structures. Our results indicated that αMR may exert its anti-obesity effects via circulating quercetin metabolites, perhaps by regulating the AMPKα-Sirt1-PPARγ pathway and TRPV1 channels [9,10]. We are designing studies to investigate these effects.…”

Section: Discussionmentioning

confidence: 92%

“…Green tea catechins, cacao oligomeric procyanidins, and glucomannan have been shown to reduce lipid absorption [5][6][7][8]. Resveratrol, a natural polyphenolic compound found in berries, has been shown to regulate lipid metabolism through AMP-activated protein kinase α (AMPKα), silent information regulator 2 homolog 1 (Sirt1), and the peroxisome proliferator-activated receptor γ (PPARγ) pathway in zebrafish [9]. Chili pepper capsaicin has been reported to activate transient receptor potential cation channel sub-family V member 1 (TRPV1) channels and reduce energy expenditure directly by activating brown adipose tissue [10].…”

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confidence: 99%

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Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice

Yokoyama¹,

Tanaka²,

Hashizume³

et al. 2018

FFHD

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Citation: Yokoyama D., Tanaka W., Hashizune Y., Tandia M., Sakono M., Shimoi K., Sakakibara H. Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice. ABSTRACTBackground: Alpha monoglucosyl-rutin (4 G -α-D-glucopyranosyl rutin, αMR) has been shown to stimulate antioxidant defenses and anti-glycation. We evaluated the effects of αMR on body weight gain in mice. Methods:Male C57BL/6J mice were divided into four groups: Control low-fat diet, low-fat Page 354 of 371 diet + 0.5% αMR, high-fat diet, and high-fat diet + 0.5% αMR. Blood chemistry, hepatic lipids, and serum metabolic hormones and cytokines were evaluated after 4 and 13 weeks.Results: After 6 weeks, the high-fat diet group gained more weight than the low-fat diet group. Supplementing the high-fat diet with αMR suppressed weight gain by week 13.Visceral fat weight was higher in the high-fat diet group on weeks 4 and 13, while αMR supplementation inhibited increase on week 13 but not on week 4. Serum levels of gastric inhibitory polypeptide were higher in the high-fat-diet group than in the low-fat-diet group.αMR supplementation inhibited this elevation and regulated levels of serum leptin and hepatic triglycerides. Conclusion:For the first time, we demonstrated how daily consumption of αMR inhibits diet-induced visceral fat accumulation by regulating the secretion of gastric inhibitory polypeptide, which thereby prevents excess weight gain. Therefore, αMR may be a promising potential functional food. BACKGROUNDThe analysis of life insurance data reveals how obesity is associated with increased death rates, as obesity involves highly elevated risks of adverse health outcomes such as type 2 diabetes mellitus and cardiovascular disease [1,2]. Obesity can be categorized either as total obesity (body mass index ≥ 25.0 kg/m 2 ) and severe obesity (body mass index ≥ 30.0 kg/m 2 ).The prevalence of obesity worldwide has been estimated to reach 18% for men and surpass 21% for women by 2025, with severe obesity surpassing 6% in men and 9% in women in developed countries [3]. The economic burden of obesity-related diseases has been estimated to be around $48-66 billion/year in the US and £1.9-2 billion/year in the UK by 2030 [4]. Therefore, prevention of excess body weight gain and obesity is a high research priority.Weight gain results from a chronic positive energy balance, occurring when energy expenditure is lower than energy intake. Consequently, management of daily food αMR, α-monoglucosyl rutin; LFD, low-fat diet (control); HFD, high-fat diet. 1 Energy values were calculated using Atwater factors; 4 kcal/g for soluble nitrogen-free products and crude protein, and 9 kcal/g for crude lipid.

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Section: Discussionmentioning

confidence: 92%

mentioning

confidence: 99%

Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice

Yokoyama¹,

Tanaka²,

Hashizume³

et al. 2018

FFHD

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“…A similar effect was observed in our previous study, where RV only enhanced the hepatic enzyme production of the ∆6-desaturase, a key enzyme in LC-PUFA synthesis, when trout were fed diets lacking fish oil (Torno et al, 2017). A bi-directional interaction of RV with the lipid metabolism of zebra fish has been recently investigated (Ran et al, 2017). The n-3 LC-PUFA enhancing effects of RV could be additionally mediated through a direct impact on other elongases and desaturases in the FA synthesis (Momchilova et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of resveratrol and genistein on growth, nutrient utilization and fatty acid composition of rainbow trout

Torno

Staats

Pascual‐Teresa

et al. 2019

Animal

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The replacement of the finite and costly resource fish oil is an important task for aquaculture nutrition. A promising approach could be the use of plant bioactives that may have the potential to influence the metabolism and the synthesis of n-3 long chain polyunsaturated fatty acids, especially EPA (20:5n-3) and DHA (22:6n-3). In this study, the two phytochemicals resveratrol (RV) and genistein (G) were investigated for their effects on fish growth, nutrient utilization and body nutrient composition alongside their effects on whole body fatty acid (FA) composition. In a feeding trial lasting 8 weeks, rainbow trout (initial BW: 81.4±0.5 g) were held in a recirculating aquaculture system and fed six experimental diets with varying fish oil levels as plain variants or supplemented with 0.3% of dry matter (DM) of either RV or G. The six diets were as follows: diet F4 had 4% DM fish oil, diet F0 had 0% DM fish oil, diets F4+RV, F4+G, F0+RV and F0+G were equal to the diets F4 and F0, respectively, and supplemented with the phytochemicals RV and G. The feeding of the F0+RV diet resulted in reduced feed intake, growth rate and slightly reduced whole body lipid levels. At the same time, the amount of polyunsaturated FA and the n-3/n-6 ratio were significantly increased in whole body homogenates of rainbow trout fed diet F0+RV in comparison to the F0 control. The feeding of the F0+G diet led to reduced feed intake, slightly increased protein utilization but did not significantly affect the whole body FA composition. Overall, feeding the fish oil-free diet supplemented with the phytochemicals resulted in more pronounced effects on fish performance and FA composition than the single factors per se (dietary fish oil level or phytochemical). Present data indicate that G might not be of profitable use for trout nutrition. In terms of FA composition, RV could be a potentially useful complement for fish oil. However, the impairment of growth and performance parameters as observed in the present study discourages its use in trout diets.

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“…In this section, we summarize the effect of resveratrol on SIR1 regulation in lifespan and health benefit. In the overfed zebrafish model, resveratrol modulates lipid metabolism by activating the AMPKα‐Sirt1‐PPARγ pathway . Resveratrol ameliorates aging‐related metabolic phenotypes by suppressing cyclic adenosine monophosphate (cAMP), phosphodiesterases (PDEs) leading to elevated cAMP levels in diet‐induced obesity mice .…”

Section: The Effect Of Resveratrol and Pterostilbene On Age‐related Mmentioning

confidence: 99%

Effect of resveratrol and pterostilbene on aging and longevity

2017

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Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as antiaging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence. In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and highcalorie diets. Moreover, we also discuss the positive effect of Abbreviations: ABTS, 2,2 0 -Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid; Akt, v-akt murine thymoma viral oncogene; AMPK, AMP-activated kinase; ARE, antioxidant response element; C. elegans, Caenorhabditis elegans; cAMP, cyclic adenosine monophosphate; CCL3, C-C motif chemokine ligand 3; CNS, central nervous system; CREB, cAMP response element binding protein; CRP, c-reactive protein; DPPH, 2,2-diphenyl-1-picryl-hydrazyl; eNOS, endothelial nitric oxide synthase; ERK, extracellular-signal-regulated kinase; ER-a, estrogen receptor alpha; FOXO1, forkhead box protein O1; FOXO3, forkhead box O3A protein; GSH, glutathione; GSH-Px, glutathione peroxidase; GSK3b, glycogen synthase kinase 3 b; hTERT, human telomerase reverse transcriptase; HtrA2, HtrA serine peptidase 2; IDH2, dehydrogenase 2; IFN-c, interferon gamma; IL-18, interleukin-18; IL-1b, interleukin 1 b; IL-6, interleukin-6; LDL, low-density lipoprotein; LPS, lipopolysaccharides; MAPK, mitogen-activated protein kinase; MLC, myosin light chain; MMP-1, matrix metalloproteinase-1; MMP-2, matrix metalloproteinase-2; MMP-9, matrix metalloproteinase-9; MnSOD, manganese superoxide dismutase; mRNA, messenger RNA; mtROS, mitochondrial reactive oxygen species; NADPH, nicotinamide adenine dinucleotide phosphate; NALP-3, NACHT 5 LRR and PYD domainscontaining protein 3; NAMPT, nicotinamide phosphoribosyltransferase; NFAT, nuclear factor of activated T-cells; NF-rB, nuclear factor-jB; NO, nitric oxide; Nrf2, nuclear factor erythroid 2-related factor 2; NS, Nutritional Supplement; OA, osteoarthritis; oxoLDL, oxidized low-density lipoprotein; PARK7, Parkinson disease protein 7; PARKIN, parkinson juvenile disease protein; PGC-1a, peroxisome proliferator-activated receptor gamma coactivator 1-a; PINK1, PTEN-induced putative kinase 1; PKB, protein kinase B; RhoA, Ras homolog gene family 5 member A; ROCK2, Rho-associated 5 coiled-coil containing protein kinase 2; ROS, reactive oxygen species; SAMP8, senescence accelerated mouse-prone 8; SCID, severe combined immunodeficiency; SHR, spontaneously hypertensive rat; SIRT1, sirtuin 1; SIRT4, sirtuin 4; SOD, superoxide peroxidase; STZ, streptozotocin; T2D, type 2 diabetes; TIMP-1, TIMP metallopeptidase inhibitor 1; TLR5, toll-like receptor 5; TNF-a, tumor necrosis factor alpha; UVB, ultraviol...

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Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio)

Cited by 52 publications

References 44 publications

Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice

Daily consumption of monoglucosyl-rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice

Effects of resveratrol and genistein on growth, nutrient utilization and fatty acid composition of rainbow trout

Effect of resveratrol and pterostilbene on aging and longevity

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