Results of the treatment of keratocystic odontogenic tumours using enucleation and treatment of the residual bony defect with Carnoy's solution

Leung, Yiu Yan; Lau, S.L.; Tsoi, Key Yan; Ma, Hsissen; Ng, Chester

doi:10.1016/j.ijom.2016.02.002

Cited by 46 publications

(56 citation statements)

References 24 publications

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“…Another point of concern is the potential occurrence of temporary damages to the alveolar inferior nerve if CS is applied directly to nerve structures [13]. In a previous study, 25 of 83 patients experienced an inferior alveolar nerve deficit; 21 of these 25 patients experienced recovery of sensitivity after a mean time of 4.6 months [14].…”

Section: Discussionmentioning

confidence: 99%

Long-term observation of a large keratocystic odontogenic tumour of the mandible treated by a single enucleation procedure: A case report and literature review

Pittl

Meier

Hakl

et al. 2017

International Journal of Surgery Case Reports

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HighlightsKeratocystic odontogenic tumours (KCOTs) are rare, benign lesions of the jaw.We present a 49-year-old woman with a rare, large KCOT of the mandible.We describe a treatment method involving enucleation with Carnoy’s solution plus inserting a titanium plate.Although the patient showed recurrence once, she has not shown recurrence since 2010.Our approach was effective for the treatment of a large KCOT with tooth preservation.

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Section: Discussionmentioning

confidence: 99%

Long-term observation of a large keratocystic odontogenic tumour of the mandible treated by a single enucleation procedure: A case report and literature review

Pittl

Meier

Hakl

et al. 2017

International Journal of Surgery Case Reports

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“…20,21,22 The benefits of complementary treatment are relevant, but there is insufficient evidence to prove its efficacy for OKCs associated with NBCCS, which have a theoretical higher risk of recurrence.…”

Section: Introductionmentioning

confidence: 99%

Reclassification and treatment of odontogenic keratocysts: A cohort study

et al. 2017

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The odontogenic keratocyst (OKC) is a recurrent cyst that has been recently reclassified from an odontogenic tumor to an odontogenic cyst. The aim of the present study was to investigate its treatment and address issues related to its association with nevoid basal cell carcinoma syndrome (NBCCS). Lesions from the cohort of patients included in the present study consisted of 40 OKCs, of which 27 lesions were treated by enucleation (GE) and 13 underwent decompression (GD). Complementary treatment occurred in 38 (95%) lesions, of which 10 underwent isolated peripheral ostectomy (GO) and 28 underwent peripheral ostectomy combined with Carnoy's solution (GC). Thirteen lesions were associated with NBCCS (GS), while the others (n=27) were non-syndromic lesions (GnS). The recurrence-free periods (RFP) in the sample groups were compared using the Kaplan-Meier function and log-rank test at a significance level of 5% (p < 0.05) and were used to calculate the cumulative risk of recurrence (CRR) in each postoperative year. During the follow-up period, which had a mean of 43.5 months (range: 12-102 months), six (15%) recurrences were diagnosed. There was no significant difference among the RFP for the compared groups (p > 0.05) or increased CRR for the decompression (15.4%) over five years. Application of Carnoy's solution did not increase the efficacy of the peripheral ostectomy, but was related to a CRR of 0% for the syndromic lesions over five years. Therefore, 1) decompression did not increase the recurrence risk; 2) peripheral ostectomy demonstrated a similar efficacy as the combination with Carnoy's solution; 3) the association of NBCCS did not seem to significantly influence OKC recurrence; and 4) syndromic lesions seem to behave in the same manner as non-syndromic lesions when submitted to complementary treatments.

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“…This solution is a chemical cauterization agent used at first as fixative and it is composed by chloroform, absolute ethanol, glacial acetil acid and ferric chloride in different concentrations. The Carnoy's solution was widely described in literature and proposed as adjuvant treatment after enucleation to reduce the lesion relapse [4,6]. It should promote chemical necrosis of up to 1.5 mm eliminating the epithelial remnants and possible daughter cysts [13].…”

Section: Discussionmentioning

confidence: 99%

“…The OKCs represent the 11% of all the jaw lesions of a similar kind and are frequently associated with Gorlin Goltz syndrome (or nevoid basal cell carcinoma syndrome) [3,4].…”

Section: Introductionmentioning

confidence: 99%

Factors influencing the recurrence of keratocysts: monocentric study

Giovacchini

Bensi

Paradiso

et al. 2019

J Oral Med Oral Surg

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Introduction: The purpose of the study was to retrospectively analyse the recurrence rate of odontogenic keratocysts and to identify eventual features of the lesions that may influence recurrence. Material and methods: This was a retrospective study carried out for a period of 3 years. The medical records of patients treated in our institution were analysed to identify all the cases of odontogenic keratocysts. Results: A total of 16 odontogenic keratocysts were recorded. These lesions were treated with simple enucleation with or without adjuvant Carnoy's solution. The relapse occurred in 4 patients treated with simple enucleation and in none of the patients that underwent enucleation and Carnoy's solution application. The kind of treatment appeared not to influence recurrence rate at statistical analysis. Conclusions: Odontogenic keratocyst is a lesion with a locally aggressive behavior and a high tendency to relapse. This tendency of recurrence may be greater with syndromic presentation of odontogenic keratocyst, with soft tissue involvement, and with teeth proximity to the lesion. The application of Carnoy's solution may be useful to minimize recurrence rate in those odontogenic keratocysts with an aggressive clinical behavior and secondly may be used for all the other lesions treated with simple enucleation that experienced relapse.

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Results of the treatment of keratocystic odontogenic tumours using enucleation and treatment of the residual bony defect with Carnoy's solution

Cited by 46 publications

References 24 publications

Long-term observation of a large keratocystic odontogenic tumour of the mandible treated by a single enucleation procedure: A case report and literature review

Long-term observation of a large keratocystic odontogenic tumour of the mandible treated by a single enucleation procedure: A case report and literature review

Reclassification and treatment of odontogenic keratocysts: A cohort study

Factors influencing the recurrence of keratocysts: monocentric study

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