Factors influencing the recurrence of keratocysts: monocentric study

Giovacchini, Francesco; Bensi, Caterina; Paradiso, Daniele; Belli, Stefano; Mitro, Valeria; Tullio, Antonio

doi:10.1051/mbcb/2019031

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…A summary of the studies is presented in Table 1 (Bello, 2016; Berge et al, 2016; Chandrashekar et al, 2020; Chirapathomsakul et al, 2006; Cottom et al, 2012; Cunha et al, 2016; de França et al, 2021; Doll et al, 2018; Fidele et al, 2019; Giovacchini et al, 2020; Habibi et al, 2007; Kaczmarzyk et al, 2018; Kuroyanagi et al, 2009; MacDonald et al, 2013; Myoung et al, 2001; Naruse et al, 2017; Naz et al, 2015; Razavi et al, 2014; Selvi et al, 2012; Tabrizi et al, 2014; Titinchi & Nortje, 2012; Yagyuu et al, 2008; Zhao et al, 2012). All studies were retrospective case controlled, case series, or laboratory based.…”

Section: Resultsmentioning

confidence: 99%

“…The quality of the studies ranged between 3 and 5 with the overall level of evidence is considered to be low. The majority of studies (19 studies) were of level 4 evidence on the CEBM guidelines (Bello, 2016; Berge et al, 2016; Chirapathomsakul et al, 2006; Cunha et al, 2016; Doll et al, 2018; Fidele et al, 2019; Giovacchini et al, 2020; Habibi et al, 2007; Kaczmarzyk et al, 2018; Kuroyanagi et al, 2009; MacDonald et al, 2013; Myoung et al, 2001; Naruse et al, 2017; Razavi et al, 2014; Selvi et al, 2012; Tabrizi et al, 2014; Titinchi & Nortje, 2012; Yagyuu et al, 2008; Zhao et al, 2012) while two studies were of level 3 evidence (Cottom et al, 2012; de França et al, 2021) and two of level 5 evidence (Chandrashekar et al, 2020; Naz et al, 2015). No prospective controlled trials or cohort studies were conducted in the literature on this topic.…”

Section: Resultsmentioning

confidence: 99%

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Novel recurrence risk stratification of odontogenic keratocysts: A systematic review

Titinchi

2021

Oral Diseases

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The aim of this study was to identify all clinical, radiological, histopathological, and immunohistochemical features associated with recurrence of odontogenic keratocysts (OKCs) in the literature and formulate a recurrence risk stratification based on these findings. A search was performed in PubMed/Medline, Scopus, Web of Science, Google Scholar and Cochrane databases for clinical and laboratory studies reporting on clinico‐pathological features that led to OKC recurrences for the period 2000 to 2020. Twenty‐three studies were identified and analyzed qualitatively. A total of 2064 OKCs were included of which 439 OKCs were recurrent with a mean follow‐up period of 46.7 months. Significantly associated parameters with OKC recurrence included age (variable age categories), large (>4 cm), multilocular lesions with cortical perforation, association with dentition, presence of daughter cysts, and epithelial budding. Immunohistochemical markers including high Ki67 index and AgNOR count were also implicated. A recurrence risk stratification was formulated based on these findings. Although the level of evidence from the included studies was low, there was considerable evidence that the clinico‐pathological parameters identified were linked with higher OKC recurrence. The surgeon, radiologist, and pathologist should aim to identify these features when making a diagnosis so as to determine the appropriate management regime and prevent recurrences.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Novel recurrence risk stratification of odontogenic keratocysts: A systematic review

Titinchi

2021

Oral Diseases

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“…The recurrence rate of OKC ranges from 5% to 62% (17). The reasons for recurrence of OKC include (1,(18)(19)(20):…”

Section: Explanation Of Findingsmentioning

confidence: 99%

Wolf in sheep’s clothing—an odontogenic keratocyst clinically masquerading as a dentigerous cyst: a case report

Mohandas¹,

Shekatkar²,

Yadahalli³

et al. 2023

Front Oral Maxillofac Med

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Background: Odontogenic keratocyst (OKC) is a developmental odontogenic cyst, infamous for its aggressive nature and high recurrence rate. Sometimes, an OKC may be misdiagnosed as any other maxillofacial cyst, based on the clinical and radiological presentation, especially when present in the toothbearing areas. A proper clinico-radiographico-pathological diagnostic workup is crucial for a definitive diagnosis and to reduce the chances of recurrence. Here, we report a case of an OKC closely associated with an impacted maxillary right third molar, clinically and radiographically resembling a dentigerous cyst.Case Description: A 28-year-old male patient complained of pain, swelling, and fluid discharge in the upper right back tooth region. The cone-beam computed tomogram revealed a well-defined, corticated cystic radiolucency that appeared to be attached to the cervical aspect of the impacted maxillary right third molar, suggestive of dentigerous cyst. Under general anaesthesia, the entire cystic lining and the impacted maxillary third molar were surgically removed using the Caldwell-Luc procedure. The histopathology was consistent with features of an OKC. There were no adverse or unanticipated events post-surgery. The patient has been kept under close follow-up and has not shown any clinical or radiographic evidence of recurrence after six months of surgery.Conclusions: A complete clinical, radiographic and histopathological correlation is imperative, along with advanced molecular analysis to arrive at the final diagnosis of an OKC which can help in understanding the pathogenesis and determining the treatment plan.

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“…(6) During the years, many conservative and aggressive treatments have been proposed to minimize the high rate of recurrence, but none of them has been recognized as the gold standard for this entity. (7) Even, marsupialization is successful management for OKC; moreover, it might be linked with the return of the lining epithelium to the normal condition, and decrease recurrency-traits not generally related to tumor. (8) The last fourth edition of the WHO Classification of Head and Neck tumors restores the OKC to cysts category and declines the prior name KCOT; it considered as a developmental cyst with more aggressive behavior.…”

Section: Introductionmentioning

confidence: 99%

Odontogenic Keratocyst

Hamied

Al-Shaikhani

Ali

2021

Al-Kindy Col. Med. J

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Purpose: to review in detail various aspects of odontogenic keratocyst, emphasizing recent nomenclature, clinical, histopathological, recurrence, and management of odontogenic keratocyst. Methods: To achieve the objective of this review, a manual search was done in hard copy books of oral and maxillofacial pathology, and an electronic search was done in the google website, oral and maxillofacial pathology E-books, virtual database sites, such as PubMed, Research Gate, Academia, and Google scholar using the descriptors: odontogenic cyst, kerato odontogenic tumor, odontogenic keratocyst, and jaws cystic lesion. The eligibility criteria for selecting articles were: to be in the English language, studies published in journals, or indexed in these databases until 2021. Exclusion criteria were: articles in any languages other than English, studies presented in duplicate between the bases, whose theme did not contemplate the objective proposed in this review, or those not available in the digital environment. Data collection occurred from October to December 2020, followed by a thorough evaluation of the studies found, including an exploratory, selective, analytical, and interpretative reading. Summary and conclusions: the odontogenic keratocyst is noteworthy because of its unusual growth pattern, the tendency to recur, and association with an inherited syndrome. The renaming of odontogenic keratocysts as keratocystic odontogenic tumors has been one of the most debatable changes in the terminology of odontogenic lesions in recent years. Early diagnose of this lesion is important to perform the more conservative treatment. A wait-and-see policy, with yearly follow-up for the first five years and every two years after that, is strongly advocated.

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Factors influencing the recurrence of keratocysts: monocentric study

Cited by 5 publications

References 25 publications

Novel recurrence risk stratification of odontogenic keratocysts: A systematic review

Novel recurrence risk stratification of odontogenic keratocysts: A systematic review

Wolf in sheep’s clothing—an odontogenic keratocyst clinically masquerading as a dentigerous cyst: a case report

Odontogenic Keratocyst

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