Results of the national soft‐tissue sarcoma registry

Mettlin, Curtis; Priore, Roger L.; Rao, U.; Gamble, D. L.; Lane, Whitney O.; Murphy, Patrick

doi:10.1002/jso.2930190410

Cited by 55 publications

(29 citation statements)

References 5 publications

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“…The median age, 54 years, is higher than that in the AJC series -43 years -but agrees with a report of 191 cases collected by the National Soft Tissue Sarcoma Registry (Mettlin et al, 1982) in which the median age was 58.5 years.…”

Section: Resultssupporting

confidence: 88%

Combined modality management of local and disseminated adult soft tissue sarcomas: A review of 257 cases seen over 10 years at the Christie Hospital & Holt Radium Institute, Manchester

Bramwell¹,

Crowther²,

Deakin³

et al. 1985

Br J Cancer

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Summary Over a 10 year period, between 1974-1984, 257 adult cases of tissue sarcoma have been evaluated in the Department of Medical Oncology, Christie Hospital, Manchester. At registration locally advanced or metastatic diseases was present in 162 (63%). The male/female ratio was 1.5:1 and median age 54 years (range 14-85). The commonest sites were lower limb (33%), visceral (21%), trunk (13%), retroperitoneum (12%) and upper limb (10%). Leiomyosarcoma (27%), liposarcoma (14%) malignant fibrous histiocytoma (10%) and neuro plus fibrosarcomas (15%) were the most frequent histological subtypes. A high proportion of uterine sarcomas (17%) is a point of distinction from many other series. Histological grade was specified in 72% of cases and the distribution (Grade 1-27%; 11-6%; 111-67%) reflected a referral bias towards advanced disease. Local resection of the primary tumour was performed in 76% of cases.In many instances this only amounted to 'shelling out' and true compartmental excisions were rare. Amputation was performed in 31% of patients with limb sarcomas. Ninety-eight patients (38%) had experienced one or more local recurrences prior to referral and the overall local recurrence rate was 56%. Suitable patients (78%) received chemotherapy, 50% entering multicentre trials in collaboration with the EORTC. The commonest regime used in patients with advanced disease was CYVADIC which produced an overall response rate of 37%. Ifosfamide, used as a single agent in 16 patients, induced 3CR and 5PR for an overall response rate of 50%.When used in combination with MTX and VADIC, there was no difference in response rate, but numbers in these pilot studies were small. Seventeen high risk patients received adjuvant chemotherapy with VAC, but the results (11 relapses) were disappointing. An EORTC trial, comparing adjuvant CYVADIC chemotherapy with control has acrrued 307 patients, 49 of these from the Christie Hospital.Preliminary results within this centre -13/25 relapses in the control arm, 5/23 in the chemotherapy armsuggest an advantage for chemotherapy but the data are statistically not significant. Post-operative radical radiotherapy after resection of the primary tumour or local recurrence was performed in 51 patients, with local control in 65% of cases, although metastases developed in 41%. At the time of analysis (1st April 1984) 98 (38%) were alive, of whom 72 showed no evidence of disease and 52 had never relapsed. Malignant disease was the cause of death in 92%. Overall survival was not influenced by sex, but patients less than 40 years of age fared significantly better (P<0.001). Survival was better for patients with sarcomas of the extremities and trunk than for visceral tumours, whereas those in the head, neck, thorax and peritoneum did significantly worse (P<0.001). As shown in many other series, histological grade had a highly significant influence on survival (P<0.001), in favour of low grade (I) tumours, whereas histological subtype was unimportant (P=0.22). Although the incidence of local recurrence ...

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Section: Resultssupporting

confidence: 88%

Combined modality management of local and disseminated adult soft tissue sarcomas: A review of 257 cases seen over 10 years at the Christie Hospital & Holt Radium Institute, Manchester

Bramwell¹,

Crowther²,

Deakin³

et al. 1985

Br J Cancer

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“…3 The prognosis reported in the world literature is poor with a 5-year OS of 36-58% and a mortality largely associated with a high rate of local recurrence. 4 The presentation of RPS in our study was uniform in both genders.…”

Section: Discussionmentioning

confidence: 99%

“…2 Approximately 10-20% of these cases are derived from the retroperitoneum with a prevalence of ∼0.3-0.4 cases/100,000 inhabitants. 3 The prognosis for patients with retroperitoneal sarcomas (RPS) is relatively poor with a 36-58% 5-year overall survival (OS) and a natural history characterized by late recurrences. 4 RPS are commonly asymptomatic until they reach great dimensions.…”

Section: Introductionmentioning

confidence: 99%

Oncology outcomes in Retroperitoneal sarcomas: Prognostic factors in a Retrospective Cohort study

García-Ortega

Villa-Zepeda

Saíd

et al. 2016

International Journal of Surgery

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“…Dedifferentiated LS may be particularly difficult to recognize because they exhibit variable histologic findings but most frequently they resemble unclassified malignant fibrous histiocytoma-like pleomorphic sarcoma or intermediate- to high-grade myxofibrosarcoma [2]. …”

Section: Discussionmentioning

confidence: 99%

A Case of Myxoid Liposarcoma of the Retroperitoneum: A Challenging Tumour for Diagnosis and Treatment

Grasso¹,

Marino²,

Bottalico³

et al. 2014

Case Reports in Surgery

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Retroperitoneal sarcomas are rare neoplasms that account for only 1%-2% of all solid tumors and liposarcomas represent the most frequent histological type. We describe the case of a 44-year-old female with a retroperitoneal myxoid liposarcoma of 22 × 19 × 8 cm in size. The only symptoms were persistent pain and progressive tenderness of the abdomen lasting for two months. The mass was radically excised during laparotomy. CT and MRI were useful to clarify the site of origin of the tumor, relationships with other organs, and planning surgery but final diagnosis was based on histological findings. Here we review the literature about the challenging diagnosis, treatment, and prognostic factors of this disease.

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Results of the national soft‐tissue sarcoma registry

Cited by 55 publications

References 5 publications

Combined modality management of local and disseminated adult soft tissue sarcomas: A review of 257 cases seen over 10 years at the Christie Hospital & Holt Radium Institute, Manchester

Combined modality management of local and disseminated adult soft tissue sarcomas: A review of 257 cases seen over 10 years at the Christie Hospital & Holt Radium Institute, Manchester

Oncology outcomes in Retroperitoneal sarcomas: Prognostic factors in a Retrospective Cohort study

A Case of Myxoid Liposarcoma of the Retroperitoneum: A Challenging Tumour for Diagnosis and Treatment

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