Results of Recent Studies and Experiments Concerning Metals Used Ix the Internal Fixation of Fractures

Venable, Charles S.; Stuck, Walter G.

doi:10.2106/00004623-194830010-00036

Cited by 27 publications

(6 citation statements)

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“…Such automatic recovery does not happen for large bone fractures, which suggests a need for bone repair with grafts to fill the gap. The easiest way is to fix the two ends of broken bones with different metal plates or rods, which was called ''internal fixation'' (Venable and Stuck 1948;Burch 1958;Deyerle and Bowers 1962;Schatzker et al 1975). In many years of study, people have optimized stainless steel, cobalt chrome alloys, titanium, and titanium alloy materials with surface modifications and proper screws for internal fixation over other materials (Schatzker et al 1975;Uhthoff et al 1981;Head et al 1995;Disegi and Eschbach 2000).…”

Section: Bone Healing and Repair With Graftsmentioning

confidence: 99%

Advances in bone repair with nanobiomaterials: mini-review

Zhang

Mao

et al. 2011

Cytotechnology

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Nanotechnology has emerged to be one of the most powerful engineering approaches in the past half a century. Nanotechnology brought nanomaterials for biomedical use with diverse applications. In the present manuscript we summarize the recent progress in adopting nanobiomaterials for bone healing and repair approaches. We first discuss the use of nanophase surface modification in manipulating metals and ceramics for bone implantation, and then the use of polymers as nanofiber scaffolds in bone repair. Finally we briefly present the potential use of the nanoparticle delivery system as adjunct system in promoting bone regeneration following fracture.

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Section: Bone Healing and Repair With Graftsmentioning

confidence: 99%

Advances in bone repair with nanobiomaterials: mini-review

Zhang

Mao

et al. 2011

Cytotechnology

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“…Nonetheless, most metallic materials do not degrade and are prone to stress shielding, modulus mismatch and immune reactions in surrounding tissues [ 32 , 200 , 201 ]. As a candidate metallic material, magnesium (Mg) alloys have shown promise in developing novel orthopedic implants due to their favourable biodegradable features and suitable mechanical properties [ 202 ].…”

Section: Nano-medicine In Bone Repairmentioning

confidence: 99%

The advances in nanomedicine for bone and cartilage repair

Qiao

Tang

et al. 2022

J Nanobiotechnol

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With the gradual demographic shift toward an aging and obese society, an increasing number of patients are suffering from bone and cartilage injuries. However, conventional therapies are hindered by the defects of materials, failing to adequately stimulate the necessary cellular response to promote sufficient cartilage regeneration, bone remodeling and osseointegration. In recent years, the rapid development of nanomedicine has initiated a revolution in orthopedics, especially in tissue engineering and regenerative medicine, due to their capacity to effectively stimulate cellular responses on a nanoscale with enhanced drug loading efficiency, targeted capability, increased mechanical properties and improved uptake rate, resulting in an improved therapeutic effect. Therefore, a comprehensive review of advancements in nanomedicine for bone and cartilage diseases is timely and beneficial. This review firstly summarized the wide range of existing nanotechnology applications in the medical field. The progressive development of nano delivery systems in nanomedicine, including nanoparticles and biomimetic techniques, which are lacking in the current literature, is further described. More importantly, we also highlighted the research advancements of nanomedicine in bone and cartilage repair using the latest preclinical and clinical examples, and further discussed the research directions of nano-therapies in future clinical practice. Graphical Abstract

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“…In 1850, screws were applied for the first time in orthopedic surgery by the French surgeons Cucel and Rigaud, who used two wood screws and a leather strap to fixate an olecranon fracture [ 3 ]. In the early 20 th century, William O’Neill Sherman (1880–1979) was a pioneer of internal fracture fixation who modified conventional screw designs to orthopedic applications [ 4 ]. Of note, Sherman’s screw design remained the “gold standard” in orthopedics until the introduction of the AO screw half a century later [ 5 ].…”

Section: Background: a Brief History Of Bone Screw Designmentioning

confidence: 99%

Introducing the “Bone-Screw-Fastener” for improved screw fixation in orthopedic surgery: a revolutionary paradigm shift?

et al. 2017

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BackgroundConventional screws used for fracture fixation in orthopedic surgery continue to rely on the historic buttress thread design. While buttress screws generally provide solid resistance against unidirectional axial loading forces, their design suffers from several limitations, as the buttress thread does not adequately resist multiaxial forces. Furthermore, the buttress screw is prone to stripping at the bone-screw interface and can cause microfracturing of the surrounding bone due to its thread design. Standard buttress screws are therefore at risk of adverse postoperative outcomes secondary to failure of bone fixation. A new patented Bone-Screw-Fastener was recently designed that is based on an interlocking thread technology. This new fastener provides distributive forces from the threads onto the bone and therefore resists loads in multiple directions. The underlying concept is represented by a “female thread” bone cutting technology designed to maximize bone volume, preserve bone architecture, and create a circumferential interlocking interface between the implant and bone that protects the thread from stripping and from failing to multiaxial forces.Presentation of the hypothesisWe hypothesize that the new Bone-Screw-Fastener overcomes the classic shortcomings of conventional orthopedic screws with buttress threads by ease of insertion, improved bone preservation, increased resistance to off-axis multidirectional loading forces and to stripping of the threads. These advanced biomechanical and biological properties can potentially mitigate the classic limitations of conventional buttress screws by providing better resistance to implant failure under physiological loads, preserving bone biology, and thus potentially improving patient outcomes in the future.Testing the hypothesisThe presumed superiority of the new fastener will require testing and validation in well-designed prospective multicenter randomized controlled trials (RCTs), using the conventional buttress screw as control.Implications of the hypothesisOnce validated in multicenter RCTs, the new Bone-Screw-Fastener may drive a change in paradigm with regard to its innovative biomechanical principles and biologic bone preservation for surgical applications requiring screw fixation.

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Results of Recent Studies and Experiments Concerning Metals Used Ix the Internal Fixation of Fractures

Cited by 27 publications

References 0 publications

Advances in bone repair with nanobiomaterials: mini-review

Advances in bone repair with nanobiomaterials: mini-review

The advances in nanomedicine for bone and cartilage repair

Introducing the “Bone-Screw-Fastener” for improved screw fixation in orthopedic surgery: a revolutionary paradigm shift?

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