Results of long term testosterone replacement therapy in men with abdominal obesity, erectile dysfunction and testosterone deficiency

Fillo, J.; Breza, J; Ondrušová, Martina; Luha, Ján; Ondruš, D; Dubravicky, J.; Labas, P; Levcikova, M.

doi:10.4149/bll_2018_061

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Erectile dysfunction (ED) is characterised as the inability to achieve or maintain an erection to complete sexual intercourse or another chosen sexual activity suffi ciently (1,2,3,4,5). It is known that ED is more common in patients with type 2 diabetes mellitus (DM) and metabolic syndrome (MS) (6,7).…”

Section: Introductionmentioning

confidence: 99%

Natural polyphenols improve erectile function and lipid profile in patients suffering from erectile dysfunction

Trebatický¹,

Muchová²,

Žiaran³

et al. 2019

BLL

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OBJECTIVES: Erectile dysfunction (ED) is characterised as the inability to achieve or maintain an erection to complete sexual intercourse. ED may be considered as an early complication of diabetes mellitus (DM). The aim of this study was to assess the effect of registered food supplement, natural polyphenolic extract from the French maritime pine bark, Pycnogenol (PYC) on erectile function and lipid profi le in ED patients. METHODS: 53 patients with ED were divided into two groups (32 with DM, 21 non-DM) in randomised, blinded and placebo-controlled study. During 3-month intervention with PYC or placebo and one month after the end of the intervention patients were investigated for ED with validated questionnaire International Index of Erectile Function-5 (IIEF-5); lipid profi le, glycaemia was analysed in each group. RESULTS: In a randomised, blinded and placebo-controlled study, we found that natural polyphenolic extract, Pycnogenol improved erectile function in DM group by 45 % compared to the NDM group, where the improvement was also signifi cant, but only by 22 %. Total cholesterol, LDL-cholesterol and glucose level was lowered by PYC in patients with DM. Glucose level was not affected by PYC in non-DM. Placebo showed no effect on monitored parameters in both groups. CONCLUSION: Administration of Pycnogenol leads in improvement of erectile function in patients with ED and diabetes (DM group) by 45 %, in NDM group by 22 %, in lowering of total-, LDL-cholesterol by 20 % and 21 % and glycaemia by 22 % in DM (Tab. 2, Fig. 2, Ref. 19).

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Section: Introductionmentioning

confidence: 99%

Natural polyphenols improve erectile function and lipid profile in patients suffering from erectile dysfunction

Trebatický¹,

Muchová²,

Žiaran³

et al. 2019

BLL

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“…Positive effect of long-term TRT on quality of life was observed also in males with an abdominal obesity (18).…”

Section: Discussionmentioning

confidence: 67%

The effect of long term testosterone replacement therapy on bone mineral density

Fillo¹,

Levcikova²,

Luha³

et al. 2019

BLL

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OBJECTIVE: Long-term results of testosterone replacement therapy (TRT) on bone mineral density (BMD) in literature are still missing. MATERIALS AND METHODS: Totally, 45 males with testosterone defi ciency syndrome (TDS) underwent TRT. The mean age was 57.84 years and the follow-up period was 94.62 months. Males were treated with three-month intramuscular injections of 1000 mg testosterone undecanoate. BMD was check at beginning of treatment, after two years and after 5 years. For a statistic evaluation, nonparametric Wilcoxon test was used. RESULTS: Mean BMD of lumbar spine was 1.067 at beginning, 1.122 after two years and 1.667 and after 5 years. The results after two and also 5 years showed a signifi cant improvement (p < 0.001). CONCLUSION: Authors proved a positive effect of long-term TRT on BMD of the lumbar spine. Densitometry of the whole hip showed also an improvement, but only after 5 years. Densitometry of the femoral neck was relatively stable. Important is that despite the fact that males became older, BMD values of the lumbar spine were improved (Fig. 6, Ref. 18).

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Results of long term testosterone replacement therapy in men with abdominal obesity, erectile dysfunction and testosterone deficiency

Abstract: TRT had multiple positive effect on affected men with TDS. Our long-term results showed a long mild improvement during the time. Authors concluded that long term treatment had multiple benefit for affected men (Fig. 11, Ref. 13).

Cited by 2 publications

References 10 publications

Natural polyphenols improve erectile function and lipid profile in patients suffering from erectile dysfunction

Natural polyphenols improve erectile function and lipid profile in patients suffering from erectile dysfunction

The effect of long term testosterone replacement therapy on bone mineral density

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