The effect of long term testosterone replacement therapy on bone mineral density

Abstract

OBJECTIVE: Long-term results of testosterone replacement therapy (TRT) on bone mineral density (BMD) in literature are still missing. MATERIALS AND METHODS: Totally, 45 males with testosterone defi ciency syndrome (TDS) underwent TRT. The mean age was 57.84 years and the follow-up period was 94.62 months. Males were treated with three-month intramuscular injections of 1000 mg testosterone undecanoate. BMD was check at beginning of treatment, after two years and after 5 years. For a statistic evaluation, nonparametric Wilcoxon test was used. RESULTS: Mean BMD of lumbar spine was 1.067 at beginning, 1.122 after two years and 1.667 and after 5 years. The results after two and also 5 years showed a signifi cant improvement (p < 0.001). CONCLUSION: Authors proved a positive effect of long-term TRT on BMD of the lumbar spine. Densitometry of the whole hip showed also an improvement, but only after 5 years. Densitometry of the femoral neck was relatively stable. Important is that despite the fact that males became older, BMD values of the lumbar spine were improved (Fig. 6, Ref. 18).

Risk factors for decreased bone mineral density in men with type 2 diabetes.

“…Установлено, что тестостерон влияет преимущественно на трабекулярную костную ткань [13]. Заместительная терапия андрогенами повышает МПК поясничного отдела позвоночника [14]. С этим согласуются наши данные о преимущественном влиянии низкого уровня тестостерона на МПК в позвоночнике у мужчин с СД2, где преобладает трабекулярная (губчатая) костная ткань.…”